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Article: Prospective study on a novel treatment for leaking cystic bleb: Efficacy and safety of collagen crosslinking
Title | Prospective study on a novel treatment for leaking cystic bleb: Efficacy and safety of collagen crosslinking |
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Authors | |
Keywords | Bleb leak Crosslinking Cystic bleb Filtering bleb |
Issue Date | 2019 |
Publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEO |
Citation | Clinical and Experimental Ophthalmology, 2019, v. 47 n. 6, p. 749-756 How to Cite? |
Abstract | Importance:
Management of cystic bleb leak is difficult. It would be essential to look for a method to strengthen the original pathological conjunctiva and reverse bleb leak.
Background:
To evaluate the long‐term efficacy and safety of collagen crosslinking in patients with leaking cystic bleb.
Design:
Prospective interventional case series at a university‐based hospital.
Participants:
Twelve eyes in 12 subjects with late‐onset bleb leak from cystic bleb, without indications for prompt surgical interventions were included.
Methods:
The subjects underwent crosslinking with 0.1% riboflavin application to bleb surface, followed by ultraviolet irradiation for 30 minutes. The subjects were followed up at baseline and at 1 week, 1 month, 3 months, 6 months post‐treatment and then every 6 months afterwards.
Main Outcome Measures:
Interval from treatment to cessation of bleb leak, recurrence rate of bleb leak and side effects of treatment.
Results:
The mean follow‐up after crosslinking was 29.33 ± 12.45 months. Bleb leak subsided in 11 (92%) of 12 patients after a single session of crosslinking, after 1 to 8 weeks (median 3 weeks). Time to leak cessation was significantly correlated with the number of prior glaucoma interventions (R = .71, P = .014). Bleb wall at 3 months was significantly thicker than at baseline (0.70 ± 0.67 vs 0.81 ± 0.62 mm, P = .008). None of the patients experienced any complications.
Conclusions and Relevance:
Crosslinking achieves resolution of cystic bleb leak which lasts for at least 12 months, without the need of subsequent surgical interventions. Crosslinking is a simple, non‐invasive treatment for bleb leak. It aims to restore the integrity of conjunctiva. |
Persistent Identifier | http://hdl.handle.net/10722/271915 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.368 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Cai, Y | - |
dc.contributor.author | Choy, BNK | - |
dc.contributor.author | Zhu, MM | - |
dc.contributor.author | Li, BB | - |
dc.contributor.author | Chan, JCH | - |
dc.contributor.author | Ho, WL | - |
dc.contributor.author | Lai, JSM | - |
dc.date.accessioned | 2019-07-20T10:31:59Z | - |
dc.date.available | 2019-07-20T10:31:59Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Clinical and Experimental Ophthalmology, 2019, v. 47 n. 6, p. 749-756 | - |
dc.identifier.issn | 1442-6404 | - |
dc.identifier.uri | http://hdl.handle.net/10722/271915 | - |
dc.description.abstract | Importance: Management of cystic bleb leak is difficult. It would be essential to look for a method to strengthen the original pathological conjunctiva and reverse bleb leak. Background: To evaluate the long‐term efficacy and safety of collagen crosslinking in patients with leaking cystic bleb. Design: Prospective interventional case series at a university‐based hospital. Participants: Twelve eyes in 12 subjects with late‐onset bleb leak from cystic bleb, without indications for prompt surgical interventions were included. Methods: The subjects underwent crosslinking with 0.1% riboflavin application to bleb surface, followed by ultraviolet irradiation for 30 minutes. The subjects were followed up at baseline and at 1 week, 1 month, 3 months, 6 months post‐treatment and then every 6 months afterwards. Main Outcome Measures: Interval from treatment to cessation of bleb leak, recurrence rate of bleb leak and side effects of treatment. Results: The mean follow‐up after crosslinking was 29.33 ± 12.45 months. Bleb leak subsided in 11 (92%) of 12 patients after a single session of crosslinking, after 1 to 8 weeks (median 3 weeks). Time to leak cessation was significantly correlated with the number of prior glaucoma interventions (R = .71, P = .014). Bleb wall at 3 months was significantly thicker than at baseline (0.70 ± 0.67 vs 0.81 ± 0.62 mm, P = .008). None of the patients experienced any complications. Conclusions and Relevance: Crosslinking achieves resolution of cystic bleb leak which lasts for at least 12 months, without the need of subsequent surgical interventions. Crosslinking is a simple, non‐invasive treatment for bleb leak. It aims to restore the integrity of conjunctiva. | - |
dc.language | eng | - |
dc.publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEO | - |
dc.relation.ispartof | Clinical and Experimental Ophthalmology | - |
dc.subject | Bleb leak | - |
dc.subject | Crosslinking | - |
dc.subject | Cystic bleb | - |
dc.subject | Filtering bleb | - |
dc.title | Prospective study on a novel treatment for leaking cystic bleb: Efficacy and safety of collagen crosslinking | - |
dc.type | Article | - |
dc.identifier.email | Choy, BNK: bnkchoy@hku.hk | - |
dc.identifier.email | Chan, JCH: jonochan@hku.hk | - |
dc.identifier.email | Ho, WL: hwl069@hku.hk | - |
dc.identifier.email | Lai, JSM: laism@hku.hk | - |
dc.identifier.authority | Choy, BNK=rp01795 | - |
dc.identifier.authority | Chan, JCH=rp02113 | - |
dc.identifier.authority | Lai, JSM=rp00295 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1111/ceo.13520 | - |
dc.identifier.scopus | eid_2-s2.0-85066046356 | - |
dc.identifier.hkuros | 298533 | - |
dc.identifier.volume | 47 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 749 | - |
dc.identifier.epage | 756 | - |
dc.identifier.isi | WOS:000480289200009 | - |
dc.publisher.place | Australia | - |
dc.identifier.issnl | 1442-6404 | - |