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- Publisher Website: 10.1016/j.neuroscience.2018.09.016
- Scopus: eid_2-s2.0-85055648015
- PMID: 30266683
- WOS: WOS:000451069300007
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Article: Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced Neurotoxicity in Alzheimer’s Disease Models In vitro and In vivo
Title | Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced Neurotoxicity in Alzheimer’s Disease Models In vitro and In vivo |
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Authors | |
Keywords | Alzheimer's disease aquaporin 9 APPswe/PS1dE9 beta-amyloid apoptosis |
Issue Date | 2018 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience |
Citation | Neuroscience, 2018, v. 394, p. 72-82 How to Cite? |
Abstract | Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, characterized by progressive cognitive dysfunction. Aquaporin 9 (AQP9) is an aquaglyceroporin membrane channel shown biophysically to conduct water, glycerol, and other small solutes. In our study, we reported for the first time an age-associated decrease in AQP9 mRNA and protein expressions in both hippocampus and cerebral cortex of APPswe/PS1dE9 (Tg) AD mice at 3, 6 and 10 months of age. Consistently, we observed a dose-dependent downregulation of AQP9 expression in PC12 cells after treatment with amyloid-beta protein 1–40 (Aβ1–40). Pre-treatment with AQP9 small interfering RNA led to a more severe neurotoxicity in PC12 cells in response to Aβ1–40. Furthermore, we corroborated that the active participation of AQP9 in AD progression is associated with Aβ-induced apoptosis both in vitro and in vivo. Taken together, our results reveal an important role of AQP9 in Aβ-induced pathogenesis of AD which deserves further investigation. |
Persistent Identifier | http://hdl.handle.net/10722/271407 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.903 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LIU, J | - |
dc.contributor.author | CHEN, XX | - |
dc.contributor.author | Chen, HY | - |
dc.contributor.author | Shi, J | - |
dc.contributor.author | Leung, GPH | - |
dc.contributor.author | Tang, SCW | - |
dc.contributor.author | Lao, LX | - |
dc.contributor.author | Yip, HKF | - |
dc.contributor.author | Lee, KF | - |
dc.contributor.author | Sze, SCW | - |
dc.contributor.author | Zhang, ZJ | - |
dc.contributor.author | Zhang, KY | - |
dc.date.accessioned | 2019-06-24T01:09:16Z | - |
dc.date.available | 2019-06-24T01:09:16Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Neuroscience, 2018, v. 394, p. 72-82 | - |
dc.identifier.issn | 0306-4522 | - |
dc.identifier.uri | http://hdl.handle.net/10722/271407 | - |
dc.description.abstract | Alzheimer’s disease (AD) is the most common cause of dementia in the elderly, characterized by progressive cognitive dysfunction. Aquaporin 9 (AQP9) is an aquaglyceroporin membrane channel shown biophysically to conduct water, glycerol, and other small solutes. In our study, we reported for the first time an age-associated decrease in AQP9 mRNA and protein expressions in both hippocampus and cerebral cortex of APPswe/PS1dE9 (Tg) AD mice at 3, 6 and 10 months of age. Consistently, we observed a dose-dependent downregulation of AQP9 expression in PC12 cells after treatment with amyloid-beta protein 1–40 (Aβ1–40). Pre-treatment with AQP9 small interfering RNA led to a more severe neurotoxicity in PC12 cells in response to Aβ1–40. Furthermore, we corroborated that the active participation of AQP9 in AD progression is associated with Aβ-induced apoptosis both in vitro and in vivo. Taken together, our results reveal an important role of AQP9 in Aβ-induced pathogenesis of AD which deserves further investigation. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience | - |
dc.relation.ispartof | Neuroscience | - |
dc.subject | Alzheimer's disease | - |
dc.subject | aquaporin 9 | - |
dc.subject | APPswe/PS1dE9 | - |
dc.subject | beta-amyloid | - |
dc.subject | apoptosis | - |
dc.title | Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced Neurotoxicity in Alzheimer’s Disease Models In vitro and In vivo | - |
dc.type | Article | - |
dc.identifier.email | Chen, HY: haiyong@hku.hk | - |
dc.identifier.email | Shi, J: junshi@hku.hk | - |
dc.identifier.email | Leung, GPH: gphleung@hkucc.hku.hk | - |
dc.identifier.email | Tang, SCW: scwtang@hku.hk | - |
dc.identifier.email | Lao, LX: lxlao1@hku.hk | - |
dc.identifier.email | Lee, KF: ckflee@hku.hk | - |
dc.identifier.email | Zhang, ZJ: zhangzj@hkucc.hku.hk | - |
dc.identifier.email | Zhang, KY: ybzhang@hku.hk | - |
dc.identifier.authority | Chen, HY=rp01923 | - |
dc.identifier.authority | Leung, GPH=rp00234 | - |
dc.identifier.authority | Tang, SCW=rp00480 | - |
dc.identifier.authority | Lao, LX=rp01784 | - |
dc.identifier.authority | Yip, HKF=rp00285 | - |
dc.identifier.authority | Lee, KF=rp00458 | - |
dc.identifier.authority | Zhang, ZJ=rp01297 | - |
dc.identifier.authority | Zhang, KY=rp01410 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.neuroscience.2018.09.016 | - |
dc.identifier.pmid | 30266683 | - |
dc.identifier.scopus | eid_2-s2.0-85055648015 | - |
dc.identifier.hkuros | 297956 | - |
dc.identifier.volume | 394 | - |
dc.identifier.spage | 72 | - |
dc.identifier.epage | 82 | - |
dc.identifier.isi | WOS:000451069300007 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 0306-4522 | - |