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- Publisher Website: 10.1038/s41467-019-09652-6
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- PMID: 30971703
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Article: Age-specific differences in the dynamics of protective immunity to influenza
Title | Age-specific differences in the dynamics of protective immunity to influenza |
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Authors | |
Keywords | antibody response dynamics enzyme linked immunosorbent assay genetic difference immune response |
Issue Date | 2019 |
Publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html |
Citation | Nature Communications, 2019, v. 10 n. 1, p. article no. 1660 How to Cite? |
Abstract | Influenza A viruses evolve rapidly to escape host immunity, causing reinfection. The form and duration of protection after each influenza virus infection are poorly understood. We quantify the dynamics of protective immunity by fitting individual-level mechanistic models to longitudinal serology from children and adults. We find that most protection in children but not adults correlates with antibody titers to the hemagglutinin surface protein. Protection against circulating strains wanes to half of peak levels 3.5–7 years after infection in both age groups, and wanes faster against influenza A(H3N2) than A(H1N1)pdm09. Protection against H3N2 lasts longer in adults than in children. Our results suggest that influenza antibody responses shift focus with age from the mutable hemagglutinin head to other epitopes, consistent with the theory of original antigenic sin, and might affect protection. Imprinting, or primary infection with a subtype, has modest to no effect on the risk of non-medically attended infections in adults. |
Persistent Identifier | http://hdl.handle.net/10722/271404 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 4.887 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ranjeva, S | - |
dc.contributor.author | Subramanian, R | - |
dc.contributor.author | Fang, VJ | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Ip, DKM | - |
dc.contributor.author | Perera, RAPM | - |
dc.contributor.author | Peiris, JSM | - |
dc.contributor.author | Cowling, BJ | - |
dc.contributor.author | Cobey, S | - |
dc.date.accessioned | 2019-06-24T01:09:12Z | - |
dc.date.available | 2019-06-24T01:09:12Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Nature Communications, 2019, v. 10 n. 1, p. article no. 1660 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10722/271404 | - |
dc.description.abstract | Influenza A viruses evolve rapidly to escape host immunity, causing reinfection. The form and duration of protection after each influenza virus infection are poorly understood. We quantify the dynamics of protective immunity by fitting individual-level mechanistic models to longitudinal serology from children and adults. We find that most protection in children but not adults correlates with antibody titers to the hemagglutinin surface protein. Protection against circulating strains wanes to half of peak levels 3.5–7 years after infection in both age groups, and wanes faster against influenza A(H3N2) than A(H1N1)pdm09. Protection against H3N2 lasts longer in adults than in children. Our results suggest that influenza antibody responses shift focus with age from the mutable hemagglutinin head to other epitopes, consistent with the theory of original antigenic sin, and might affect protection. Imprinting, or primary infection with a subtype, has modest to no effect on the risk of non-medically attended infections in adults. | - |
dc.language | eng | - |
dc.publisher | Nature Research (part of Springer Nature): Fully open access journals. The Journal's web site is located at http://www.nature.com/ncomms/index.html | - |
dc.relation.ispartof | Nature Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | antibody response | - |
dc.subject | dynamics | - |
dc.subject | enzyme linked immunosorbent assay | - |
dc.subject | genetic difference | - |
dc.subject | immune response | - |
dc.title | Age-specific differences in the dynamics of protective immunity to influenza | - |
dc.type | Article | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Ip, DKM: dkmip@hku.hk | - |
dc.identifier.email | Perera, RAPM: mahenp@hku.hk | - |
dc.identifier.email | Peiris, JSM: malik@hkucc.hku.hk | - |
dc.identifier.email | Cowling, BJ: bcowling@hku.hk | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Ip, DKM=rp00256 | - |
dc.identifier.authority | Perera, RAPM=rp02500 | - |
dc.identifier.authority | Peiris, JSM=rp00410 | - |
dc.identifier.authority | Cowling, BJ=rp01326 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41467-019-09652-6 | - |
dc.identifier.pmid | 30971703 | - |
dc.identifier.pmcid | PMC6458119 | - |
dc.identifier.scopus | eid_2-s2.0-85064244132 | - |
dc.identifier.hkuros | 298023 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 1660 | - |
dc.identifier.epage | article no. 1660 | - |
dc.identifier.isi | WOS:000463984400009 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 2041-1723 | - |