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Article: A possible role of biogenic silica in esophageal cancer in North China?

TitleA possible role of biogenic silica in esophageal cancer in North China?
Authors
KeywordsEnvironmental geochemistry
Esophageal squamous cell carcinoma (ESCC)
Biogenic silica
Wheat chaff
Silica phytolith
Issue Date2019
PublisherSpringer. The Journal's web site is located at http://www.springer.com/environment/journal/11356
Citation
Environmental Science and Pollution Research, 2019, v. 26 n. 8, p. 8340-8343 How to Cite?
AbstractCertain areas in North China have the highest incidence of esophageal squamous cell carcinoma (ESCC) in the world, which has not seen convincing explanation by any risk factor yet. Biogenic silica in millet bran was linked to ESCC in the early 1980s but the hypothesis was largely dismissed because of the lack of geographic correlation between millet consumption and ESCC. Later epidemiological studies disclosed the linkage of wheat consumption in North China to ESCC instead. Now, we hypothesize silica phytoliths (silicified bodies that have definite shapes) from wheat chaff are a major etiologic factor of ESCC in this region. This hypothesis is supported by the potentially high abundance of silica phytoliths on the bracts of wheat (Triticum aestivum) in North China due to favorable Si-accumulation genotype, arid climate, and siallitic soil with bioavailable Si. These silica phytoliths can contaminate wheat flour and cause repeated local injuries in the esophagus and stimulate proliferation by providing anchorage.
Persistent Identifierhttp://hdl.handle.net/10722/271403
ISSN
2020 Impact Factor: 4.223
2015 SCImago Journal Rankings: 0.886
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLian, C-
dc.contributor.authorZuo, X-
dc.contributor.authorTian, L-
dc.date.accessioned2019-06-24T01:09:11Z-
dc.date.available2019-06-24T01:09:11Z-
dc.date.issued2019-
dc.identifier.citationEnvironmental Science and Pollution Research, 2019, v. 26 n. 8, p. 8340-8343-
dc.identifier.issn0944-1344-
dc.identifier.urihttp://hdl.handle.net/10722/271403-
dc.description.abstractCertain areas in North China have the highest incidence of esophageal squamous cell carcinoma (ESCC) in the world, which has not seen convincing explanation by any risk factor yet. Biogenic silica in millet bran was linked to ESCC in the early 1980s but the hypothesis was largely dismissed because of the lack of geographic correlation between millet consumption and ESCC. Later epidemiological studies disclosed the linkage of wheat consumption in North China to ESCC instead. Now, we hypothesize silica phytoliths (silicified bodies that have definite shapes) from wheat chaff are a major etiologic factor of ESCC in this region. This hypothesis is supported by the potentially high abundance of silica phytoliths on the bracts of wheat (Triticum aestivum) in North China due to favorable Si-accumulation genotype, arid climate, and siallitic soil with bioavailable Si. These silica phytoliths can contaminate wheat flour and cause repeated local injuries in the esophagus and stimulate proliferation by providing anchorage.-
dc.languageeng-
dc.publisherSpringer. The Journal's web site is located at http://www.springer.com/environment/journal/11356-
dc.relation.ispartofEnvironmental Science and Pollution Research-
dc.subjectEnvironmental geochemistry-
dc.subjectEsophageal squamous cell carcinoma (ESCC)-
dc.subjectBiogenic silica-
dc.subjectWheat chaff-
dc.subjectSilica phytolith-
dc.titleA possible role of biogenic silica in esophageal cancer in North China?-
dc.typeArticle-
dc.identifier.emailTian, L: linweit@hku.hk-
dc.identifier.authorityTian, L=rp01991-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11356-019-04332-w-
dc.identifier.pmid30689109-
dc.identifier.scopuseid_2-s2.0-85061047375-
dc.identifier.hkuros298214-
dc.identifier.volume26-
dc.identifier.issue8-
dc.identifier.spage8340-
dc.identifier.epage8343-
dc.identifier.isiWOS:000463824600090-
dc.publisher.placeGermany-
dc.identifier.issnl0944-1344-

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