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Conference Paper: Intermittent versus continuous thoracic spinal cord stimulation for treatment of ischemic heart failure

TitleIntermittent versus continuous thoracic spinal cord stimulation for treatment of ischemic heart failure
Authors
Issue Date2012
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
ESC Congress 2012, Munich, Germany, 29 August 2012, Abstracts In Europen Heart Journal, 2012, v. 33 n. suppl. 1, p. 963-964, abstract no. 5264 How to Cite?
AbstractBackground: Prior experimental studies showed that spinal cord stimulation (SCS) improved left ventricular (LV) function in animal model of ischemic heart failure (HF). Nevertheless, the optimal approach and duration of thoracic SCS is unknown. Methods: We performed chronic thoracic SCS at T1-T2 level (50Hz frequency, pulse width 0.2ms) in 30 adult pigs with ischemic HF induced by myocardial infarction (MI) via coronary embolization of left circumflex artery followed by rapid ventricular pacing for 4 weeks (MI+HF). All animals were treated with daily oral metoprolol ZOK (50 mg) plus ramipril (2.5 mg), and randomized into control group (n=10), intermittent SCS (4hrs x3, n=10) or continuous SCS (24hrs, n=10) for 10 weeks. Echocardiogram and invasive hemodynamic assessment to determine LV ejection fraction (LVEF) and +dP/dt, respectively, and blood sampling to measure serum norepinephrine (NE) and B-type natriuretic peptide (BNP) levels as baseline, immediately after MI (post-MI), at MI+HF and at 10wks follow-up. Results: Echocardiogram showed significant increase in LVEF and +dP/dt at 10 wks in both intermittent SCS group and continuous SCS group as compared with control group (P<0.05, Figure 1). However, there were no significant differences in LVEF and +dP/dt between intermittent vs. continuous SCS group (P>0.05,Figure 1). Nevertheless, only continuous SCS group had significant decreased in serum NE and BNP at 10wks as compared with control group (P<0.05, Figure 2). Conclusions: In porcine model of ischemic HF, addition of either intermittent or continuous SCS to medical therapy improves LV contractile function compared with medical therapy alone. However, continuous SCS, but not intermittent SCS is associated with significant reduction of serum NE and BNP compared with medical therapy alone.
DescriptionInvited Speaker
Persistent Identifierhttp://hdl.handle.net/10722/270738
ISSN
2019 Impact Factor: 22.673
2015 SCImago Journal Rankings: 6.997

 

DC FieldValueLanguage
dc.contributor.authorTse, HF-
dc.contributor.authorLiu, Y-
dc.contributor.authorZuo, M-
dc.contributor.authorLiao, SY-
dc.contributor.authorYue, W-
dc.contributor.authorSiu, CW-
dc.contributor.authorShuto, C-
dc.contributor.authorCary, H-
dc.contributor.authorPark, E-
dc.contributor.authorChen, P-
dc.date.accessioned2019-06-06T08:38:59Z-
dc.date.available2019-06-06T08:38:59Z-
dc.date.issued2012-
dc.identifier.citationESC Congress 2012, Munich, Germany, 29 August 2012, Abstracts In Europen Heart Journal, 2012, v. 33 n. suppl. 1, p. 963-964, abstract no. 5264-
dc.identifier.issn0195-668X-
dc.identifier.urihttp://hdl.handle.net/10722/270738-
dc.descriptionInvited Speaker-
dc.description.abstractBackground: Prior experimental studies showed that spinal cord stimulation (SCS) improved left ventricular (LV) function in animal model of ischemic heart failure (HF). Nevertheless, the optimal approach and duration of thoracic SCS is unknown. Methods: We performed chronic thoracic SCS at T1-T2 level (50Hz frequency, pulse width 0.2ms) in 30 adult pigs with ischemic HF induced by myocardial infarction (MI) via coronary embolization of left circumflex artery followed by rapid ventricular pacing for 4 weeks (MI+HF). All animals were treated with daily oral metoprolol ZOK (50 mg) plus ramipril (2.5 mg), and randomized into control group (n=10), intermittent SCS (4hrs x3, n=10) or continuous SCS (24hrs, n=10) for 10 weeks. Echocardiogram and invasive hemodynamic assessment to determine LV ejection fraction (LVEF) and +dP/dt, respectively, and blood sampling to measure serum norepinephrine (NE) and B-type natriuretic peptide (BNP) levels as baseline, immediately after MI (post-MI), at MI+HF and at 10wks follow-up. Results: Echocardiogram showed significant increase in LVEF and +dP/dt at 10 wks in both intermittent SCS group and continuous SCS group as compared with control group (P<0.05, Figure 1). However, there were no significant differences in LVEF and +dP/dt between intermittent vs. continuous SCS group (P>0.05,Figure 1). Nevertheless, only continuous SCS group had significant decreased in serum NE and BNP at 10wks as compared with control group (P<0.05, Figure 2). Conclusions: In porcine model of ischemic HF, addition of either intermittent or continuous SCS to medical therapy improves LV contractile function compared with medical therapy alone. However, continuous SCS, but not intermittent SCS is associated with significant reduction of serum NE and BNP compared with medical therapy alone. -
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/-
dc.relation.ispartofEuropean Heart Journal-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here]. -
dc.titleIntermittent versus continuous thoracic spinal cord stimulation for treatment of ischemic heart failure-
dc.typeConference_Paper-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.hkuros204098-
dc.identifier.volume33-
dc.identifier.issuesuppl. 1-
dc.identifier.spage963-
dc.identifier.epage964, abstract no. 5264-
dc.publisher.placeUnited Kingdom-

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