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Conference Paper: Identification of DNA methylation of distal regulatory regions with causal effect on tumorigenesis
Title | Identification of DNA methylation of distal regulatory regions with causal effect on tumorigenesis |
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Authors | |
Issue Date | 2018 |
Publisher | Omics Publishing Group. The Journal's web site is located at http://www.omicsonline.org/geneticshome.php |
Citation | 4th International Congress on Epigenetics & Chromatin, London, UK, 3-5 September 2018. In Hereditary Genetics: Current Research, 2018, v. 7, p. 69 How to Cite? |
Abstract | Aberrant promoter methylation is a common mechanism for tumor-suppressor inactivation in cancer. However, the exact role of DNA methylation at enhancers remains to be elucidated. We have developed a set of tools to genome-wide identify DNA methylation in distal regions with causal effect on tumorigenesis. Novel oncogenes/tumor-suppressors and their putative enhancers can be identified together based on this strategy. Many predictions were directly demonstrated by dCas9-based epigenetic editing with strong evidence to support the accuracy and efficiency of our tool. Our study reveals the prevalent regulation of genomewide putative enhancers by DNA-methylation with causal effect on cellular malignancy and patient survival. Mechanistically, oncogenic and lineage-specific transcriptional-factors aberrantly shaped the methylation landscape with diverged tumor-subtype
core regulatory circuitry. Notably, the gene regulatory networks orchestrated by enhancer methylation across different cancer types converged on a common architecture, highlighting general organization principle for such networks regulated by DNA methylation of distal regulatory regions. |
Description | Kenote Forum |
Persistent Identifier | http://hdl.handle.net/10722/270658 |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Zhang, J | - |
dc.date.accessioned | 2019-06-05T02:37:44Z | - |
dc.date.available | 2019-06-05T02:37:44Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | 4th International Congress on Epigenetics & Chromatin, London, UK, 3-5 September 2018. In Hereditary Genetics: Current Research, 2018, v. 7, p. 69 | - |
dc.identifier.issn | 2161-1041 | - |
dc.identifier.uri | http://hdl.handle.net/10722/270658 | - |
dc.description | Kenote Forum | - |
dc.description.abstract | Aberrant promoter methylation is a common mechanism for tumor-suppressor inactivation in cancer. However, the exact role of DNA methylation at enhancers remains to be elucidated. We have developed a set of tools to genome-wide identify DNA methylation in distal regions with causal effect on tumorigenesis. Novel oncogenes/tumor-suppressors and their putative enhancers can be identified together based on this strategy. Many predictions were directly demonstrated by dCas9-based epigenetic editing with strong evidence to support the accuracy and efficiency of our tool. Our study reveals the prevalent regulation of genomewide putative enhancers by DNA-methylation with causal effect on cellular malignancy and patient survival. Mechanistically, oncogenic and lineage-specific transcriptional-factors aberrantly shaped the methylation landscape with diverged tumor-subtype core regulatory circuitry. Notably, the gene regulatory networks orchestrated by enhancer methylation across different cancer types converged on a common architecture, highlighting general organization principle for such networks regulated by DNA methylation of distal regulatory regions. | - |
dc.language | eng | - |
dc.publisher | Omics Publishing Group. The Journal's web site is located at http://www.omicsonline.org/geneticshome.php | - |
dc.relation.ispartof | Hereditary Genetics | - |
dc.relation.ispartof | 4th International Congress on Epigenetics & Chromatin, 2018 | - |
dc.title | Identification of DNA methylation of distal regulatory regions with causal effect on tumorigenesis | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Zhang, J: jzhang1@hku.hk | - |
dc.identifier.authority | Zhang, J=rp01713 | - |
dc.identifier.hkuros | 291168 | - |
dc.identifier.volume | 7 | - |
dc.identifier.spage | 69 | - |
dc.identifier.epage | 69 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 2161-1041 | - |