File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Selenium-containing block copolymers and their oxidation-responsive aggregates

TitleSelenium-containing block copolymers and their oxidation-responsive aggregates
Authors
Issue Date2010
Citation
Polymer Chemistry, 2010, v. 1, n. 10, p. 1609-1614 How to Cite?
AbstractA selenium-containing amphiphilic block copolymer (PEG-PUSe-PEG) with a hydrophobic polyselenide block and two hydrophilic poly(ethylene glycol) (PEG) blocks was synthesized via polymerization of toluene diisocyanate (TDI) with monoselenide-containing diols and subsequent termination with PEG monomethylether. PEG-PUSe-PEG is able to self-assemble in aqueous solution to form block copolymer aggregates. Interestingly, it was found that the aggregates have a good oxidation-responsiveness and undergo a structural dissociation in a mild oxidative environment (such as 0.1% H 2 O 2 v/v) due to the unique sensitivity of selenide groups in presence of oxidants. Compared with the sulfide analogue PEG-PUS-PEG, PEG-PUSe-PEG is more sensitive to oxidants. It is anticipated that selenium-containing block copolymer aggregates may find application in the field of drug delivery systems. © 2011 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/270382
ISSN
2023 Impact Factor: 4.1
2023 SCImago Journal Rankings: 0.969
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMa, Ning-
dc.contributor.authorLi, Ying-
dc.contributor.authorRen, Huifeng-
dc.contributor.authorXu, Huaping-
dc.contributor.authorLi, Zhibo-
dc.contributor.authorZhang, Xi-
dc.date.accessioned2019-05-27T03:57:28Z-
dc.date.available2019-05-27T03:57:28Z-
dc.date.issued2010-
dc.identifier.citationPolymer Chemistry, 2010, v. 1, n. 10, p. 1609-1614-
dc.identifier.issn1759-9954-
dc.identifier.urihttp://hdl.handle.net/10722/270382-
dc.description.abstractA selenium-containing amphiphilic block copolymer (PEG-PUSe-PEG) with a hydrophobic polyselenide block and two hydrophilic poly(ethylene glycol) (PEG) blocks was synthesized via polymerization of toluene diisocyanate (TDI) with monoselenide-containing diols and subsequent termination with PEG monomethylether. PEG-PUSe-PEG is able to self-assemble in aqueous solution to form block copolymer aggregates. Interestingly, it was found that the aggregates have a good oxidation-responsiveness and undergo a structural dissociation in a mild oxidative environment (such as 0.1% H 2 O 2 v/v) due to the unique sensitivity of selenide groups in presence of oxidants. Compared with the sulfide analogue PEG-PUS-PEG, PEG-PUSe-PEG is more sensitive to oxidants. It is anticipated that selenium-containing block copolymer aggregates may find application in the field of drug delivery systems. © 2011 The Royal Society of Chemistry.-
dc.languageeng-
dc.relation.ispartofPolymer Chemistry-
dc.titleSelenium-containing block copolymers and their oxidation-responsive aggregates-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1039/c0py00144a-
dc.identifier.scopuseid_2-s2.0-79958123332-
dc.identifier.volume1-
dc.identifier.issue10-
dc.identifier.spage1609-
dc.identifier.epage1614-
dc.identifier.eissn1759-9962-
dc.identifier.isiWOS:000284065700008-
dc.identifier.issnl1759-9954-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats