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Conference Paper: The regulatory roles of decidual glycodelin-A on trophoblast and immune cell functions during early pregnancy

TitleThe regulatory roles of decidual glycodelin-A on trophoblast and immune cell functions during early pregnancy
Authors
Issue Date2018
PublisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0897
Citation
American‐Sino Joint Meeting of Reproductive Immunology (ASRI‐CSI 2018), Shanghai, China, 28 June ‐1 July 2018. In American Journal of Reproductive Immunology, 2018, v. 80 n. S1, p. 28, abstract no. T19 How to Cite?
AbstractPlacenta is a potential target for maternal immunological attack. Many mechanisms have evolved to suppress the maternal immune response during pregnancy. For example, the decidua has a high degree of specialization of its resident leukocyte populations. Decidual natural killer cells and macrophages are the 2 major cell types of the maternal‐fetal interface. These decidual leukocytes play critical roles on regulating maternal immune tolerance through their interaction with each other and trophoblastic cells. They also contribute to promote placental development at the maternal‐fetal interface. Glycodelin‐A is the major glycoprotein found in the human decidua during early pregnancy. It plays an important role in placental development and feto‐maternal defense. Glycodelin‐A interacts by its unique carbohydrate side‐chains with the cell surface of various cell types in the human feto‐maternal interface, particularly the immune cells, and modulates their functions and differentiation to permit successful pregnancy. Abnormal levels of glycodelin‐A in the endometrium, uterine flushings and/or maternal serum correlate with unexplained infertility, preeclampsia, early pregnancy loss and recurrent miscarriage. This presentation integrates recent studies and our new findings on the roles of decidual glycodelin‐A in placental development and fetomaternal tolerance during early pregnancy. Further insight into the biological properties of glycodelin‐A and its glycosylation will provide better understanding of its molecular nature and biological role, and thus offer opportunities for developing new prevention and/or treatment strategies for pregnancy complications.
DescriptionB3 Immunology of Implantation and Assisted Reproductive Techology
American-Sino Joint Meeting of Reproductive Immunology 2018: The 38th Annual Meeting of the American Society for Reproductive Immunology & The 6th Annual Meeting of the Chinese Society for Reproductive Immunology
Persistent Identifierhttp://hdl.handle.net/10722/269112
ISSN
2020 Impact Factor: 3.886
2015 SCImago Journal Rankings: 1.347

 

DC FieldValueLanguage
dc.contributor.authorLee, CL-
dc.contributor.authorVijayan, M-
dc.contributor.authorKoistinen, H-
dc.contributor.authorSeppala, M-
dc.contributor.authorNg, EHY-
dc.contributor.authorYeung, WSB-
dc.contributor.authorChiu, CN-
dc.date.accessioned2019-04-12T06:45:29Z-
dc.date.available2019-04-12T06:45:29Z-
dc.date.issued2018-
dc.identifier.citationAmerican‐Sino Joint Meeting of Reproductive Immunology (ASRI‐CSI 2018), Shanghai, China, 28 June ‐1 July 2018. In American Journal of Reproductive Immunology, 2018, v. 80 n. S1, p. 28, abstract no. T19-
dc.identifier.issn1046-7408-
dc.identifier.urihttp://hdl.handle.net/10722/269112-
dc.descriptionB3 Immunology of Implantation and Assisted Reproductive Techology-
dc.descriptionAmerican-Sino Joint Meeting of Reproductive Immunology 2018: The 38th Annual Meeting of the American Society for Reproductive Immunology & The 6th Annual Meeting of the Chinese Society for Reproductive Immunology-
dc.description.abstractPlacenta is a potential target for maternal immunological attack. Many mechanisms have evolved to suppress the maternal immune response during pregnancy. For example, the decidua has a high degree of specialization of its resident leukocyte populations. Decidual natural killer cells and macrophages are the 2 major cell types of the maternal‐fetal interface. These decidual leukocytes play critical roles on regulating maternal immune tolerance through their interaction with each other and trophoblastic cells. They also contribute to promote placental development at the maternal‐fetal interface. Glycodelin‐A is the major glycoprotein found in the human decidua during early pregnancy. It plays an important role in placental development and feto‐maternal defense. Glycodelin‐A interacts by its unique carbohydrate side‐chains with the cell surface of various cell types in the human feto‐maternal interface, particularly the immune cells, and modulates their functions and differentiation to permit successful pregnancy. Abnormal levels of glycodelin‐A in the endometrium, uterine flushings and/or maternal serum correlate with unexplained infertility, preeclampsia, early pregnancy loss and recurrent miscarriage. This presentation integrates recent studies and our new findings on the roles of decidual glycodelin‐A in placental development and fetomaternal tolerance during early pregnancy. Further insight into the biological properties of glycodelin‐A and its glycosylation will provide better understanding of its molecular nature and biological role, and thus offer opportunities for developing new prevention and/or treatment strategies for pregnancy complications.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0897-
dc.relation.ispartofAmerican Journal of Reproductive Immunology-
dc.relation.ispartofAmerican‐Sino Joint Meeting of Reproductive Immunology (ASRI‐CSI 2018)-
dc.titleThe regulatory roles of decidual glycodelin-A on trophoblast and immune cell functions during early pregnancy-
dc.typeConference_Paper-
dc.identifier.emailLee, CL: kcllee@hku.hk-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.emailYeung, WSB: wsbyeung@hku.hk-
dc.identifier.emailChiu, CN: pchiucn@hku.hk-
dc.identifier.authorityLee, CL=rp02515-
dc.identifier.authorityNg, EHY=rp00426-
dc.identifier.authorityYeung, WSB=rp00331-
dc.identifier.authorityChiu, CN=rp00424-
dc.identifier.doi10.1111/aji.18_12981-
dc.identifier.hkuros296446-
dc.identifier.volume80-
dc.identifier.issueS1-
dc.identifier.spage28, abstract no. T19-
dc.identifier.epage28, abstract no. T19-
dc.publisher.placeUnited States-
dc.identifier.issnl1046-7408-

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