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- Publisher Website: 10.1016/j.humimm.2004.12.008
- Scopus: eid_2-s2.0-20444364888
- PMID: 15935888
- WOS: WOS:000230042200008
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Article: Impact of ELISA-detected anti-HLA antibodies on pediatric cardiac allograft outcome
Title | Impact of ELISA-detected anti-HLA antibodies on pediatric cardiac allograft outcome |
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Authors | |
Keywords | AR acute rejection PRA panel-reactive antibody HLA human leukocyte antigen EMB endomyocardial biopsies CAD coronary artery disease |
Issue Date | 2005 |
Citation | Human Immunology, 2005, v. 66, n. 5, p. 513-518 How to Cite? |
Abstract | In this study, we determine whether the presence of enzyme-linked immunosorbent assay (ELISA) detected anti-human leukocyte antigen (HLA) antibodies correlates with acute and chronic rejection in pediatric heart transplantation (Tx). Forty-five patients, who had serial ELISA pre- and posttransplantation, were studied. Age at Tx was 8.2 ± 7.2 years. Acute rejection (AR) was defined as International Society for Heart and Lung Transplantation Grade ≥3a. Patients were defined as rejectors (22 cases) if they had recurrent AR or steroid-resistant AR within the first year post-Tx; the other cases (23) were defined as nonrejectors. Overall, 219 samples were analyzed. Twenty-two of the 45 had pre- or post-Tx anti-HLA antibodies: 77% in rejectors (17/22) and only 22% in nonrejectors (5/23), p = 0.0002. Pre-Tx HLA antibodies were present in 12 cases (27%). Presensitization was more frequent in rejectors (11/22, 50%) than in nonrejectors (1/23, 4%, p = 0.0005). Nineteen cases retained (9 cases) or developed (10 cases) anti-HLA antibodies post-Tx: 14 in rejectors (63.6%) and 5 in nonrejectors (21.7%), p = 0.003. Four of eight cases with coronary artery disease (50%) had preformed anti-HLA antibodies compared with 8 of 37 without coronary artery disease (25.6%) (p = 0.09). Preformed, persistent, and de novo ELISA-detected anti-HLA antibodies were correlated with first-year acute rejection profile. © American Society for Histocompatibility and Immunogenetics, 2005. Published by Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/268931 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.781 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Di Filippo, Sylvie | - |
dc.contributor.author | Girnita, Alin | - |
dc.contributor.author | Webber, Steven A. | - |
dc.contributor.author | Tsao, Sabrina | - |
dc.contributor.author | Boyle, Gerard J. | - |
dc.contributor.author | Miller, Susan A. | - |
dc.contributor.author | Gandhi, Sanjiv K. | - |
dc.contributor.author | Zeevi, Adriana | - |
dc.date.accessioned | 2019-04-07T15:08:56Z | - |
dc.date.available | 2019-04-07T15:08:56Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Human Immunology, 2005, v. 66, n. 5, p. 513-518 | - |
dc.identifier.issn | 0198-8859 | - |
dc.identifier.uri | http://hdl.handle.net/10722/268931 | - |
dc.description.abstract | In this study, we determine whether the presence of enzyme-linked immunosorbent assay (ELISA) detected anti-human leukocyte antigen (HLA) antibodies correlates with acute and chronic rejection in pediatric heart transplantation (Tx). Forty-five patients, who had serial ELISA pre- and posttransplantation, were studied. Age at Tx was 8.2 ± 7.2 years. Acute rejection (AR) was defined as International Society for Heart and Lung Transplantation Grade ≥3a. Patients were defined as rejectors (22 cases) if they had recurrent AR or steroid-resistant AR within the first year post-Tx; the other cases (23) were defined as nonrejectors. Overall, 219 samples were analyzed. Twenty-two of the 45 had pre- or post-Tx anti-HLA antibodies: 77% in rejectors (17/22) and only 22% in nonrejectors (5/23), p = 0.0002. Pre-Tx HLA antibodies were present in 12 cases (27%). Presensitization was more frequent in rejectors (11/22, 50%) than in nonrejectors (1/23, 4%, p = 0.0005). Nineteen cases retained (9 cases) or developed (10 cases) anti-HLA antibodies post-Tx: 14 in rejectors (63.6%) and 5 in nonrejectors (21.7%), p = 0.003. Four of eight cases with coronary artery disease (50%) had preformed anti-HLA antibodies compared with 8 of 37 without coronary artery disease (25.6%) (p = 0.09). Preformed, persistent, and de novo ELISA-detected anti-HLA antibodies were correlated with first-year acute rejection profile. © American Society for Histocompatibility and Immunogenetics, 2005. Published by Elsevier Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Human Immunology | - |
dc.subject | AR acute rejection | - |
dc.subject | PRA panel-reactive antibody | - |
dc.subject | HLA human leukocyte antigen | - |
dc.subject | EMB endomyocardial biopsies | - |
dc.subject | CAD coronary artery disease | - |
dc.title | Impact of ELISA-detected anti-HLA antibodies on pediatric cardiac allograft outcome | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.humimm.2004.12.008 | - |
dc.identifier.pmid | 15935888 | - |
dc.identifier.scopus | eid_2-s2.0-20444364888 | - |
dc.identifier.volume | 66 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 513 | - |
dc.identifier.epage | 518 | - |
dc.identifier.isi | WOS:000230042200008 | - |
dc.identifier.issnl | 0198-8859 | - |