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Article: A new class of ultrafine anaphase bridges generated by homologous recombination
Title | A new class of ultrafine anaphase bridges generated by homologous recombination |
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Authors | |
Keywords | chromosomal instability 53BP1 Recombination intermediate MUS81 Holliday junction chromosome segregation |
Issue Date | 2018 |
Citation | Cell Cycle, 2018, v. 17, n. 17, p. 2101-2109 How to Cite? |
Abstract | © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Ultrafine anaphase bridges (UFBs) are a potential source of genome instability that is a hallmark of cancer. UFBs can arise from DNA catenanes at centromeres/rDNA loci, late replication intermediates induced by replication stress, and DNA linkages at telomeres. Recently, it was reported that DNA intertwinements generated by homologous recombination give rise to a new class of UFBs, which have been termed homologous recombination ultrafine bridges (HR-UFBs). HR-UFBs are decorated with PICH and BLM in anaphase, and are subsequently converted to RPA-coated, single-stranded DNA bridges. Breakage of these sister chromatid entanglements leads to DNA damage that can be repaired by non-homologous end joining in the next cell cycle, but the potential consequences include DNA rearrangements, chromosome translocations and fusions. Visualisation of these HR-UFBs, and knowledge of how they arise, provides a molecular basis to explain how upregulation of homologous recombination or failure to resolve recombination intermediates leads to the development of chromosomal instability observed in certain cancers. |
Persistent Identifier | http://hdl.handle.net/10722/268607 |
ISSN | 2023 Impact Factor: 3.4 2023 SCImago Journal Rankings: 0.947 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, Ying Wai | - |
dc.contributor.author | West, Stephen C. | - |
dc.date.accessioned | 2019-03-25T08:00:11Z | - |
dc.date.available | 2019-03-25T08:00:11Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Cell Cycle, 2018, v. 17, n. 17, p. 2101-2109 | - |
dc.identifier.issn | 1538-4101 | - |
dc.identifier.uri | http://hdl.handle.net/10722/268607 | - |
dc.description.abstract | © 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Ultrafine anaphase bridges (UFBs) are a potential source of genome instability that is a hallmark of cancer. UFBs can arise from DNA catenanes at centromeres/rDNA loci, late replication intermediates induced by replication stress, and DNA linkages at telomeres. Recently, it was reported that DNA intertwinements generated by homologous recombination give rise to a new class of UFBs, which have been termed homologous recombination ultrafine bridges (HR-UFBs). HR-UFBs are decorated with PICH and BLM in anaphase, and are subsequently converted to RPA-coated, single-stranded DNA bridges. Breakage of these sister chromatid entanglements leads to DNA damage that can be repaired by non-homologous end joining in the next cell cycle, but the potential consequences include DNA rearrangements, chromosome translocations and fusions. Visualisation of these HR-UFBs, and knowledge of how they arise, provides a molecular basis to explain how upregulation of homologous recombination or failure to resolve recombination intermediates leads to the development of chromosomal instability observed in certain cancers. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell Cycle | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | chromosomal instability | - |
dc.subject | 53BP1 | - |
dc.subject | Recombination intermediate | - |
dc.subject | MUS81 | - |
dc.subject | Holliday junction | - |
dc.subject | chromosome segregation | - |
dc.title | A new class of ultrafine anaphase bridges generated by homologous recombination | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1080/15384101.2018.1515555 | - |
dc.identifier.pmid | 30253678 | - |
dc.identifier.pmcid | PMC6226235 | - |
dc.identifier.scopus | eid_2-s2.0-85054739079 | - |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 17 | - |
dc.identifier.spage | 2101 | - |
dc.identifier.epage | 2109 | - |
dc.identifier.eissn | 1551-4005 | - |
dc.identifier.isi | WOS:000447180800002 | - |
dc.identifier.issnl | 1551-4005 | - |