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Conference Paper: Mature cardiomyocytes from human pluripotent stem cells for drug screening and disease modeling
Title | Mature cardiomyocytes from human pluripotent stem cells for drug screening and disease modeling |
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Authors | |
Issue Date | 2017 |
Publisher | Medcom Limited. The Journal's web site is located at http://www.hkcchk.com/journals.php#3 |
Citation | The Twenty First Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 11 November 2017. In Journal of the Hong Kong College of Cardiology, 2017, v. 25 n. 2, p. 70, abstract no. IL5 How to Cite? |
Abstract | Differentiation of human pluripotent stem cells (hPSCs) to the cardiac lineage represents a potentially unlimited source of cardiomyocytes (CMs) for research and clinical applications. Limitations to their use include their immature, embryonic-like developmental state and their heterogeneity characterized by
mixed population of cells and poorly defined function. Using a unique strategy for proteomics profiling, we identified proteins on the cell surface of hPSCCMs. Our dataset revealed an association between the expression of late protein 1 (L1), a surface protein involved in metabolism, with a more advanced
differentiation stage, Viable CMs positive for this developmental marker can be isolated by cell sorting and are more adult-like in their gene expression pattern, morphology and functions. Our work provides important proof-ofprinciple for the isolation and characterisation of mature and defined hPSCCM
subpopulations, and will greatly advance the use of hESC-derivatives for medical research, disease modelling and drug testing. |
Description | Invited Lecture |
Persistent Identifier | http://hdl.handle.net/10722/267959 |
ISSN | 2023 SCImago Journal Rankings: 0.115 |
DC Field | Value | Language |
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dc.contributor.author | Poon, NYE | - |
dc.date.accessioned | 2019-03-08T08:48:39Z | - |
dc.date.available | 2019-03-08T08:48:39Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | The Twenty First Anniversary Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 11 November 2017. In Journal of the Hong Kong College of Cardiology, 2017, v. 25 n. 2, p. 70, abstract no. IL5 | - |
dc.identifier.issn | 1027-7811 | - |
dc.identifier.uri | http://hdl.handle.net/10722/267959 | - |
dc.description | Invited Lecture | - |
dc.description.abstract | Differentiation of human pluripotent stem cells (hPSCs) to the cardiac lineage represents a potentially unlimited source of cardiomyocytes (CMs) for research and clinical applications. Limitations to their use include their immature, embryonic-like developmental state and their heterogeneity characterized by mixed population of cells and poorly defined function. Using a unique strategy for proteomics profiling, we identified proteins on the cell surface of hPSCCMs. Our dataset revealed an association between the expression of late protein 1 (L1), a surface protein involved in metabolism, with a more advanced differentiation stage, Viable CMs positive for this developmental marker can be isolated by cell sorting and are more adult-like in their gene expression pattern, morphology and functions. Our work provides important proof-ofprinciple for the isolation and characterisation of mature and defined hPSCCM subpopulations, and will greatly advance the use of hESC-derivatives for medical research, disease modelling and drug testing. | - |
dc.language | eng | - |
dc.publisher | Medcom Limited. The Journal's web site is located at http://www.hkcchk.com/journals.php#3 | - |
dc.relation.ispartof | Journal of the Hong Kong College of Cardiology | - |
dc.relation.ispartof | Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine | - |
dc.title | Mature cardiomyocytes from human pluripotent stem cells for drug screening and disease modeling | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Poon, NYE: ellpoon@hku.hk | - |
dc.identifier.authority | Poon, NYE=rp02233 | - |
dc.identifier.hkuros | 292273 | - |
dc.identifier.volume | 25 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 70, abstract no. IL5 | - |
dc.identifier.epage | 70, abstract no. IL5 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 1027-7811 | - |