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Conference Paper: Endothelial SIRT1 as a drug target for vascular ageing-related diseases.
| Title | Endothelial SIRT1 as a drug target for vascular ageing-related diseases. |
|---|---|
| Authors | |
| Issue Date | 2017 |
| Publisher | Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University. |
| Citation | The 99th Lecture, Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland, 15 December 2017 How to Cite? |
| Abstract | Ageing plays an important role in the alterations of vascular structure and function. Impaired endothelial function and increased arterial stiffness occur before the overt clinical manifestations such as hypertension and atherosclerosis. Sirtuin 1 (SIRT1), the mammalian ortholog of yeast longevity regulator Sir2, is a potent longevity regulator. Overexpression of SIRT1 in endothelium prevents cellular senescence, enhances vasodilatory responses, and attenuates ageing-induced vascular damages. Drugs targeting SIRT1 in endothelial cells represent promising therapeutics for vascular ageing-related
diseases. The expression, regulation and signaling pathways of endothelial SIRT1 will be discussed in this seminar. |
| Description | invited speaker |
| Persistent Identifier | http://hdl.handle.net/10722/267955 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wang, Y | - |
| dc.date.accessioned | 2019-03-08T07:50:21Z | - |
| dc.date.available | 2019-03-08T07:50:21Z | - |
| dc.date.issued | 2017 | - |
| dc.identifier.citation | The 99th Lecture, Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland, 15 December 2017 | - |
| dc.identifier.uri | http://hdl.handle.net/10722/267955 | - |
| dc.description | invited speaker | - |
| dc.description.abstract | Ageing plays an important role in the alterations of vascular structure and function. Impaired endothelial function and increased arterial stiffness occur before the overt clinical manifestations such as hypertension and atherosclerosis. Sirtuin 1 (SIRT1), the mammalian ortholog of yeast longevity regulator Sir2, is a potent longevity regulator. Overexpression of SIRT1 in endothelium prevents cellular senescence, enhances vasodilatory responses, and attenuates ageing-induced vascular damages. Drugs targeting SIRT1 in endothelial cells represent promising therapeutics for vascular ageing-related diseases. The expression, regulation and signaling pathways of endothelial SIRT1 will be discussed in this seminar. | - |
| dc.language | eng | - |
| dc.publisher | Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University. | - |
| dc.relation.ispartof | The 99th Lecture, Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University | - |
| dc.title | Endothelial SIRT1 as a drug target for vascular ageing-related diseases. | - |
| dc.type | Conference_Paper | - |
| dc.identifier.email | Wang, Y: yuwanghk@hku.hk | - |
| dc.identifier.authority | Wang, Y=rp00239 | - |
| dc.identifier.hkuros | 292260 | - |
| dc.publisher.place | Poland | - |