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- Publisher Website: 10.1093/aje/kwy238
- Scopus: eid_2-s2.0-85060993010
- PMID: 30358846
- WOS: WOS:000460620100025
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Article: Estimating the severity profile of Enterovirus A71 infections in children: A Bayesian Synthesis Framework
Title | Estimating the severity profile of Enterovirus A71 infections in children: A Bayesian Synthesis Framework |
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Authors | |
Keywords | Bayesian inference EV-A71 infection infection-fatality risk severity profile |
Issue Date | 2019 |
Publisher | Oxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/ |
Citation | American Journal of Epidemiology, 2019, v. 188 n. 2, p. 475-483 How to Cite? |
Abstract | Enterovirus A71 (EV-A71) is responsible for the majority of severe cases of hand, foot, and mouth disease, but little evidence is available on the severity profile of EV-A71 infections. We formulated a hierarchical Bayesian model that synthesized data on diseases/events associated with EV-A71 and EV-A71 antibody responses to infection among unvaccinated children from large clinical trials of EV-A71 vaccination, which were conducted in Jiangsu and Beijing during 2012 and 2013, to reconstruct the severity profile in a unified framework. On average, 15.1% of the children aged 6-35 months were infected by EV-A71 during 1-year follow-up in a mild epidemic season. We estimated that 9.7%, 2.2%, and 0.6% of children infected with EV-A71 were diagnosed with EV-A71-associated diseases, were hospitalized, and showed severe complications, respectively. We estimated on average 1 death per 10,000 EV-A71 infections for children aged 6-35 months. Approximately 70% of children had ≥4-fold rises in antibody titers after infection. Most EV-A71 infections in young children are mild, and overall 2.2% of the infected patients were hospitalized in the 2 trials. There remain several uncertainties about the immune response after infection and the duration of immunity against EV-A71 reinfection. |
Persistent Identifier | http://hdl.handle.net/10722/267458 |
ISSN | 2023 Impact Factor: 5.0 2023 SCImago Journal Rankings: 0.837 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yang, B | - |
dc.contributor.author | Lau, EHY | - |
dc.contributor.author | Cowling, BJ | - |
dc.date.accessioned | 2019-02-18T09:02:28Z | - |
dc.date.available | 2019-02-18T09:02:28Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | American Journal of Epidemiology, 2019, v. 188 n. 2, p. 475-483 | - |
dc.identifier.issn | 0002-9262 | - |
dc.identifier.uri | http://hdl.handle.net/10722/267458 | - |
dc.description.abstract | Enterovirus A71 (EV-A71) is responsible for the majority of severe cases of hand, foot, and mouth disease, but little evidence is available on the severity profile of EV-A71 infections. We formulated a hierarchical Bayesian model that synthesized data on diseases/events associated with EV-A71 and EV-A71 antibody responses to infection among unvaccinated children from large clinical trials of EV-A71 vaccination, which were conducted in Jiangsu and Beijing during 2012 and 2013, to reconstruct the severity profile in a unified framework. On average, 15.1% of the children aged 6-35 months were infected by EV-A71 during 1-year follow-up in a mild epidemic season. We estimated that 9.7%, 2.2%, and 0.6% of children infected with EV-A71 were diagnosed with EV-A71-associated diseases, were hospitalized, and showed severe complications, respectively. We estimated on average 1 death per 10,000 EV-A71 infections for children aged 6-35 months. Approximately 70% of children had ≥4-fold rises in antibody titers after infection. Most EV-A71 infections in young children are mild, and overall 2.2% of the infected patients were hospitalized in the 2 trials. There remain several uncertainties about the immune response after infection and the duration of immunity against EV-A71 reinfection. | - |
dc.language | eng | - |
dc.publisher | Oxford University Press. The Journal's web site is located at http://aje.oxfordjournals.org/ | - |
dc.relation.ispartof | American Journal of Epidemiology | - |
dc.rights | Pre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here]. | - |
dc.subject | Bayesian inference | - |
dc.subject | EV-A71 infection | - |
dc.subject | infection-fatality risk | - |
dc.subject | severity profile | - |
dc.title | Estimating the severity profile of Enterovirus A71 infections in children: A Bayesian Synthesis Framework | - |
dc.type | Article | - |
dc.identifier.email | Lau, EHY: ehylau@hku.hk | - |
dc.identifier.email | Cowling, BJ: bcowling@hku.hk | - |
dc.identifier.authority | Lau, EHY=rp01349 | - |
dc.identifier.authority | Cowling, BJ=rp01326 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/aje/kwy238 | - |
dc.identifier.pmid | 30358846 | - |
dc.identifier.pmcid | PMC6357812 | - |
dc.identifier.scopus | eid_2-s2.0-85060993010 | - |
dc.identifier.hkuros | 296876 | - |
dc.identifier.volume | 188 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 475 | - |
dc.identifier.epage | 483 | - |
dc.identifier.isi | WOS:000460620100025 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0002-9262 | - |