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Book Chapter: Personalized radiation therapy (PRT) for lung cancer

TitlePersonalized radiation therapy (PRT) for lung cancer
Authors
KeywordsPersonalized radiation therapy
Radiomics
Lung cancer
Biomarkers
Adaptive radiation therapy
Issue Date2016
Citation
Personalized Radiation Therapy (PRT) for Lung Cancer. In Ahmad, A and Gadgeel, S (Eds), Advances in Experimental Medicine and Biology, v. 890, p. 175-202. Cham : Springer, 2016 How to Cite?
Abstract© Springer International Publishing Switzerland 2016. This chapter reviews and discusses approaches and strategies of personalized radiation therapy (PRT) for lung cancers at four different levels: (1) clinically established PRT based on a patient’s histology, stage, tumor volume and tumor locations; (2) personalized adaptive radiation therapy (RT) based on image response during treatment; (3) PRT based on biomarkers; (4) personalized fractionation schedule. The current RT practice for lung cancer is partially individualized according to tumor histology, stage, size/location, and combination with use of systemic therapy. During-RT PET-CT image guided adaptive treatment is being tested in a multicenter trial. Treatment response detected by the during-RT images may also provide a strategy to further personalize the remaining treatment. Research on biomarker-guided PRT is ongoing. The biomarkers include genomics, proteomics, microRNA, cytokines, metabolomics from tumor and blood samples, and radiomics from PET, CT, SPECT images. Finally, RT fractionation schedule may also be personalized to each individual patient to maximize therapeutic gain. Future PRT should be based on comprehensive considerations of knowledge acquired from all these levels, as well as consideration of the societal value such as cost and effectiveness.
Persistent Identifierhttp://hdl.handle.net/10722/267019
ISBN
ISSN
2021 Impact Factor: 3.650
2023 SCImago Journal Rankings: 0.244
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJin, Jian Yue-
dc.contributor.authorKong, Feng Ming (Spring)-
dc.date.accessioned2019-01-31T07:20:16Z-
dc.date.available2019-01-31T07:20:16Z-
dc.date.issued2016-
dc.identifier.citationPersonalized Radiation Therapy (PRT) for Lung Cancer. In Ahmad, A and Gadgeel, S (Eds), Advances in Experimental Medicine and Biology, v. 890, p. 175-202. Cham : Springer, 2016-
dc.identifier.isbn9783319249315-
dc.identifier.issn0065-2598-
dc.identifier.urihttp://hdl.handle.net/10722/267019-
dc.description.abstract© Springer International Publishing Switzerland 2016. This chapter reviews and discusses approaches and strategies of personalized radiation therapy (PRT) for lung cancers at four different levels: (1) clinically established PRT based on a patient’s histology, stage, tumor volume and tumor locations; (2) personalized adaptive radiation therapy (RT) based on image response during treatment; (3) PRT based on biomarkers; (4) personalized fractionation schedule. The current RT practice for lung cancer is partially individualized according to tumor histology, stage, size/location, and combination with use of systemic therapy. During-RT PET-CT image guided adaptive treatment is being tested in a multicenter trial. Treatment response detected by the during-RT images may also provide a strategy to further personalize the remaining treatment. Research on biomarker-guided PRT is ongoing. The biomarkers include genomics, proteomics, microRNA, cytokines, metabolomics from tumor and blood samples, and radiomics from PET, CT, SPECT images. Finally, RT fractionation schedule may also be personalized to each individual patient to maximize therapeutic gain. Future PRT should be based on comprehensive considerations of knowledge acquired from all these levels, as well as consideration of the societal value such as cost and effectiveness.-
dc.languageeng-
dc.relation.ispartofAdvances in Experimental Medicine and Biology-
dc.subjectPersonalized radiation therapy-
dc.subjectRadiomics-
dc.subjectLung cancer-
dc.subjectBiomarkers-
dc.subjectAdaptive radiation therapy-
dc.titlePersonalized radiation therapy (PRT) for lung cancer-
dc.typeBook_Chapter-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/978-3-319-24932-2_10-
dc.identifier.pmid26703805-
dc.identifier.scopuseid_2-s2.0-84951875229-
dc.identifier.volume890-
dc.identifier.spage175-
dc.identifier.epage202-
dc.identifier.eissn2214-8019-
dc.identifier.isiWOS:000369068700011-
dc.identifier.issnl0065-2598-

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