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Article: Noninvasive evaluation of microscopic tumor extensions using standardized uptake value and metabolic tumor volume in non-small-cell lung cancer

TitleNoninvasive evaluation of microscopic tumor extensions using standardized uptake value and metabolic tumor volume in non-small-cell lung cancer
Authors
KeywordsStandardized uptake value
Positron emission tomography/computed tomography
Non-small-cell lung cancer
Clinical target volume margin
Metabolic tumor volume
Issue Date2012
Citation
International Journal of Radiation Oncology Biology Physics, 2012, v. 82, n. 2, p. 960-966 How to Cite?
AbstractPurpose: To prospectively evaluate whether maximal microscopic extensions (MEmax) correlate with maximal standardized uptake value (SUVmax) and metabolic tumor volume (MTV) at 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) images in non-small-cell lung cancer (NSCLC). Methods and Materials: Thirty-nine patients with Stage I-IIIA NSCLC underwent surgery after FDG-PET/CT scanning. SUVmax and MTV were calculated on the PET/CT images. The maximum linear distance from the tumor margin to the farthest extent of the tumor in every dimension was measured at the tumor section. The correlations among MEmax, SUVmax, MTV and other clinical pathologic parameters were analyzed. Results: MEmax for all patients had a significant correlation with SUVmax (r = 0.777, p = 0.008) and MTV (r = 0.724, p < 0.001). When expressed in terms of the probability of covering ME with respect to a given margin, we suggested that margins of 1.93 mm, 3.90 mm, and 9.60 mm for SUVmax ≤5, 5-10, and >10 added to the gross tumor volume would be adequate to cover 95% of ME. Conclusions: This study demonstrated that tumors with high SUVmax and MTV have more MEmax and would therefore require more margin expansion from gross tumor volume to clinical target volume. FDG-PET/CT, especially for SUVmax, is promising and effective and merits additional study in noninvasive delimiting of the clinical target volume margin for NSCLC. © 2012 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/266929
ISSN
2023 Impact Factor: 6.4
2023 SCImago Journal Rankings: 1.992
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMeng, Xue-
dc.contributor.authorSun, Xindong-
dc.contributor.authorMu, Dianbin-
dc.contributor.authorXing, Ligang-
dc.contributor.authorMa, Li-
dc.contributor.authorZhang, Baijiang-
dc.contributor.authorZhao, Shuqiang-
dc.contributor.authorYang, Guoren-
dc.contributor.authorKong, Feng Ming-
dc.contributor.authorYu, Jinming-
dc.date.accessioned2019-01-31T07:20:00Z-
dc.date.available2019-01-31T07:20:00Z-
dc.date.issued2012-
dc.identifier.citationInternational Journal of Radiation Oncology Biology Physics, 2012, v. 82, n. 2, p. 960-966-
dc.identifier.issn0360-3016-
dc.identifier.urihttp://hdl.handle.net/10722/266929-
dc.description.abstractPurpose: To prospectively evaluate whether maximal microscopic extensions (MEmax) correlate with maximal standardized uptake value (SUVmax) and metabolic tumor volume (MTV) at 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) images in non-small-cell lung cancer (NSCLC). Methods and Materials: Thirty-nine patients with Stage I-IIIA NSCLC underwent surgery after FDG-PET/CT scanning. SUVmax and MTV were calculated on the PET/CT images. The maximum linear distance from the tumor margin to the farthest extent of the tumor in every dimension was measured at the tumor section. The correlations among MEmax, SUVmax, MTV and other clinical pathologic parameters were analyzed. Results: MEmax for all patients had a significant correlation with SUVmax (r = 0.777, p = 0.008) and MTV (r = 0.724, p < 0.001). When expressed in terms of the probability of covering ME with respect to a given margin, we suggested that margins of 1.93 mm, 3.90 mm, and 9.60 mm for SUVmax ≤5, 5-10, and >10 added to the gross tumor volume would be adequate to cover 95% of ME. Conclusions: This study demonstrated that tumors with high SUVmax and MTV have more MEmax and would therefore require more margin expansion from gross tumor volume to clinical target volume. FDG-PET/CT, especially for SUVmax, is promising and effective and merits additional study in noninvasive delimiting of the clinical target volume margin for NSCLC. © 2012 Elsevier Inc.-
dc.languageeng-
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physics-
dc.subjectStandardized uptake value-
dc.subjectPositron emission tomography/computed tomography-
dc.subjectNon-small-cell lung cancer-
dc.subjectClinical target volume margin-
dc.subjectMetabolic tumor volume-
dc.titleNoninvasive evaluation of microscopic tumor extensions using standardized uptake value and metabolic tumor volume in non-small-cell lung cancer-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ijrobp.2010.10.064-
dc.identifier.pmid21440998-
dc.identifier.scopuseid_2-s2.0-84855823663-
dc.identifier.volume82-
dc.identifier.issue2-
dc.identifier.spage960-
dc.identifier.epage966-
dc.identifier.eissn1879-355X-
dc.identifier.isiWOS:000299239900075-
dc.identifier.issnl0360-3016-

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