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Article: Implementation of hypoxia measurement into lung cancer therapy

TitleImplementation of hypoxia measurement into lung cancer therapy
Authors
KeywordsHypoxia
PET imaging
Lung cancer
FMISO
FETNIM
FAZA
Issue Date2012
Citation
Lung Cancer, 2012, v. 75, n. 2, p. 146-150 How to Cite?
AbstractTumor hypoxia has been found to be a characteristic feature in lung cancer. It has been shown to decrease the therapeutic efficacy of radiotherapy and some forms of chemotherapy. New methods for qualitative and quantitative assessment of tumor oxygenation have made it possible to establish the prognostic significance of tumor hypoxia. The ability to determine the degree and extent of hypoxia in lung cancer is not only important prognostically, but also in the selection of patients for hypoxia-modifying treatments. To provide the best attainable quality of life for individual patients it is of increasing importance that tools be developed that allow a better selection of patients for these intensified treatment strategies. Although some markers and combinations have shown potential benefit and are associated with treatment outcome, their clinical usefulness needs to be validated in prospective trials. A review of published studies was carried out, focusing on the assessment of tumor hypoxia and the possibilities to overcome hypoxia during treatment in lung cancer. © 2011 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/266928
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.761
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMeng, Xue-
dc.contributor.authorKong, Feng Ming Spring-
dc.contributor.authorYu, Jinming-
dc.date.accessioned2019-01-31T07:20:00Z-
dc.date.available2019-01-31T07:20:00Z-
dc.date.issued2012-
dc.identifier.citationLung Cancer, 2012, v. 75, n. 2, p. 146-150-
dc.identifier.issn0169-5002-
dc.identifier.urihttp://hdl.handle.net/10722/266928-
dc.description.abstractTumor hypoxia has been found to be a characteristic feature in lung cancer. It has been shown to decrease the therapeutic efficacy of radiotherapy and some forms of chemotherapy. New methods for qualitative and quantitative assessment of tumor oxygenation have made it possible to establish the prognostic significance of tumor hypoxia. The ability to determine the degree and extent of hypoxia in lung cancer is not only important prognostically, but also in the selection of patients for hypoxia-modifying treatments. To provide the best attainable quality of life for individual patients it is of increasing importance that tools be developed that allow a better selection of patients for these intensified treatment strategies. Although some markers and combinations have shown potential benefit and are associated with treatment outcome, their clinical usefulness needs to be validated in prospective trials. A review of published studies was carried out, focusing on the assessment of tumor hypoxia and the possibilities to overcome hypoxia during treatment in lung cancer. © 2011 Elsevier Ireland Ltd.-
dc.languageeng-
dc.relation.ispartofLung Cancer-
dc.subjectHypoxia-
dc.subjectPET imaging-
dc.subjectLung cancer-
dc.subjectFMISO-
dc.subjectFETNIM-
dc.subjectFAZA-
dc.titleImplementation of hypoxia measurement into lung cancer therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.lungcan.2011.09.009-
dc.identifier.pmid22001441-
dc.identifier.scopuseid_2-s2.0-84855462625-
dc.identifier.volume75-
dc.identifier.issue2-
dc.identifier.spage146-
dc.identifier.epage150-
dc.identifier.eissn1872-8332-
dc.identifier.isiWOS:000300068300002-
dc.identifier.issnl0169-5002-

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