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Article: Factors associated with overall survival in 1706 patients with nasopharyngeal carcinoma: Significance of intensive neoadjuvant chemotherapy and radiation break

TitleFactors associated with overall survival in 1706 patients with nasopharyngeal carcinoma: Significance of intensive neoadjuvant chemotherapy and radiation break
Authors
KeywordsNeoadjuvant chemotherapy
Radiation break
Nasopharyngeal cancer
Issue Date2010
Citation
Radiotherapy and Oncology, 2010, v. 96, n. 1, p. 94-99 How to Cite?
AbstractBackground and purpose: To exam factors associated with overall survival (OS) in patients with nasopharyngeal carcinoma (NPC). Materials and methods: This study is a retrospective study of a total of 1706 consecutive NPC patients from a single institution between January 1995 and December 1998. One thousand eighty-one patients were treated with radiotherapy (RT) alone and 625 with an intensive course of neoadjuvant chemotherapy followed by RT. Patient, tumor and treatment factors were analyzed for their significance on 5-year overall survival (OS). Results: Younger age, female gender, absence of anemia pre-RT, early tumor stage, interruption of RT, and neoadjuvant chemotherapy were significantly associated with survival under multivariate analysis (all P < 0.05). The 5-year OS rates were 100%, 75.9% (95%CI 71.6-80.2%), 66.5% (95%CI 62.8-70.2%), and 49.3% (95%CI 45.0-53.6%) for stage I, II, III, and IV (P < 0.05); 68.9% (95%CI 66.2-71.5%) and 63.7% (95%CI 61.5-65.8%), for patients treated with or without neoadjuvant chemotherapy (P = 0.0051), and 51.7% (95%CI 45.0-58.4%) and 69.5% (95%CI 67.2-71.7%) for patients with or without treatment break (P < 0.0001), respectively. Conclusion: Intensive neoadjuvant chemotherapy and absence of radiation break seem to be favorable factors associated with long-term survival in patients with NPC. © 2010 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/266907
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 1.702
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, Luying-
dc.contributor.authorPan, Jianji-
dc.contributor.authorWu, Junxin-
dc.contributor.authorPan, Caizhu-
dc.contributor.authorZhang, Yu-
dc.contributor.authorLin, Shaojun-
dc.contributor.authorYang, Ling-
dc.contributor.authorChen, Chuanben-
dc.contributor.authorZhang, Chun-
dc.contributor.authorZheng, Wei-
dc.contributor.authorLin, Senan-
dc.contributor.authorNi, Xiaolei-
dc.contributor.author(Spring) Kong, Feng Ming-
dc.date.accessioned2019-01-31T07:19:56Z-
dc.date.available2019-01-31T07:19:56Z-
dc.date.issued2010-
dc.identifier.citationRadiotherapy and Oncology, 2010, v. 96, n. 1, p. 94-99-
dc.identifier.issn0167-8140-
dc.identifier.urihttp://hdl.handle.net/10722/266907-
dc.description.abstractBackground and purpose: To exam factors associated with overall survival (OS) in patients with nasopharyngeal carcinoma (NPC). Materials and methods: This study is a retrospective study of a total of 1706 consecutive NPC patients from a single institution between January 1995 and December 1998. One thousand eighty-one patients were treated with radiotherapy (RT) alone and 625 with an intensive course of neoadjuvant chemotherapy followed by RT. Patient, tumor and treatment factors were analyzed for their significance on 5-year overall survival (OS). Results: Younger age, female gender, absence of anemia pre-RT, early tumor stage, interruption of RT, and neoadjuvant chemotherapy were significantly associated with survival under multivariate analysis (all P < 0.05). The 5-year OS rates were 100%, 75.9% (95%CI 71.6-80.2%), 66.5% (95%CI 62.8-70.2%), and 49.3% (95%CI 45.0-53.6%) for stage I, II, III, and IV (P < 0.05); 68.9% (95%CI 66.2-71.5%) and 63.7% (95%CI 61.5-65.8%), for patients treated with or without neoadjuvant chemotherapy (P = 0.0051), and 51.7% (95%CI 45.0-58.4%) and 69.5% (95%CI 67.2-71.7%) for patients with or without treatment break (P < 0.0001), respectively. Conclusion: Intensive neoadjuvant chemotherapy and absence of radiation break seem to be favorable factors associated with long-term survival in patients with NPC. © 2010 Elsevier Ireland Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofRadiotherapy and Oncology-
dc.subjectNeoadjuvant chemotherapy-
dc.subjectRadiation break-
dc.subjectNasopharyngeal cancer-
dc.titleFactors associated with overall survival in 1706 patients with nasopharyngeal carcinoma: Significance of intensive neoadjuvant chemotherapy and radiation break-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.radonc.2010.04.006-
dc.identifier.pmid20435361-
dc.identifier.scopuseid_2-s2.0-77953960005-
dc.identifier.volume96-
dc.identifier.issue1-
dc.identifier.spage94-
dc.identifier.epage99-
dc.identifier.isiWOS:000280261500018-
dc.identifier.issnl0167-8140-

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