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Article: The relevance of transforming growth factor β1 in pulmonary injury after radiation therapy

TitleThe relevance of transforming growth factor β1 in pulmonary injury after radiation therapy
Authors
KeywordsTransforming growth factor β
Complications
Lung cancer
Radiation therapy
Issue Date1998
Citation
Lung Cancer, 1998, v. 19, n. 2, p. 109-120 How to Cite?
AbstractThe maximum dose of radiation which can be delivered to a tumor is limited by the tolerance of the surrounding normal tissues. The ability to identify patients at high or low risk of injury from radiation therapy might enable the clinician to tailor radiation doses in order to maximize efficacy and minimize risk. The cytokine transforming growth factor β1 (TGFβ1) has been implicated in the development of normal tissue injury after irradiation in several organs, including the lung. Herein, the evidence supporting the role of TGFβ1 in radiation-induced lung injury is reviewed. Using the treatment of non-small cell lung cancer as a model, we also discuss how it may be possible to identify patients at risk for this complication using measurements of plasma TGFβ1, and how this information may be used in the future to adjust doses of radiation in the treatment of lung cancer.
Persistent Identifierhttp://hdl.handle.net/10722/266763
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.761
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAnscher, Mitchell S.-
dc.contributor.authorKong, Feng Ming-
dc.contributor.authorJirtle, Randy L.-
dc.date.accessioned2019-01-31T07:19:31Z-
dc.date.available2019-01-31T07:19:31Z-
dc.date.issued1998-
dc.identifier.citationLung Cancer, 1998, v. 19, n. 2, p. 109-120-
dc.identifier.issn0169-5002-
dc.identifier.urihttp://hdl.handle.net/10722/266763-
dc.description.abstractThe maximum dose of radiation which can be delivered to a tumor is limited by the tolerance of the surrounding normal tissues. The ability to identify patients at high or low risk of injury from radiation therapy might enable the clinician to tailor radiation doses in order to maximize efficacy and minimize risk. The cytokine transforming growth factor β1 (TGFβ1) has been implicated in the development of normal tissue injury after irradiation in several organs, including the lung. Herein, the evidence supporting the role of TGFβ1 in radiation-induced lung injury is reviewed. Using the treatment of non-small cell lung cancer as a model, we also discuss how it may be possible to identify patients at risk for this complication using measurements of plasma TGFβ1, and how this information may be used in the future to adjust doses of radiation in the treatment of lung cancer.-
dc.languageeng-
dc.relation.ispartofLung Cancer-
dc.subjectTransforming growth factor β-
dc.subjectComplications-
dc.subjectLung cancer-
dc.subjectRadiation therapy-
dc.titleThe relevance of transforming growth factor β1 in pulmonary injury after radiation therapy-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0169-5002(97)00076-7-
dc.identifier.pmid9567247-
dc.identifier.scopuseid_2-s2.0-0031926223-
dc.identifier.volume19-
dc.identifier.issue2-
dc.identifier.spage109-
dc.identifier.epage120-
dc.identifier.isiWOS:000072884200003-
dc.identifier.issnl0169-5002-

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