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Article: Remineralisation of enamel with silver diamine fluoride and sodium fluoride
Title | Remineralisation of enamel with silver diamine fluoride and sodium fluoride |
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Authors | |
Keywords | Caries Demineralisation Enamel Remineralisation Silver diamine fluoride |
Issue Date | 2018 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/dental |
Citation | Dental Materials, 2018, v. 34 n. 12, p. e344-e352 How to Cite? |
Abstract | Objective: To evaluate the remineralising effect of the adjunctive application of 38% silver diamine fluoride (SDF) solution and 5% sodium fluoride (NaF) varnish on artificial enamel caries lesions. Methods: Forty-eight demineralised enamel specimens were allocated into four groups. Group 1 received 38% SDF and 5% NaF; Group 2 received 38% SDF; Group 3 received 5% NaF; and Group 4 received deionized water. After pH cycling, the surface morphology and fluoride content of the specimens were studied via scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS). The lesion depth and crystal characteristics were assessed using micro-computed tomography and X-ray diffraction (XRD) respectively. The crystallization reaction was performed by incubating hydroxyapatite powder with NaF or SDF for 48 h. The precipitates were studied via transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). Results: SEM demonstrated the destruction of the enamel surface in Group 4. EDS revealed that the mean fluoride weight percentage of Groups 1–4 were 1.28 ± 0.15, 1.33 ± 0.19, 1.03 ± 0.09 and 0.87 ± 0.04 respectively. The mean lesion depths of Groups 1–4 were 129 ± 14 μm, 131 ± 16 μm, 153 ± 10 μm and 181 ± 21 μm respectively. The addition of NaF to SDF did not reduce the lesion depths (p = 0.779). XRD revealed that silver chloride formed as a main product in Groups 1 and 2. Meanwhile, TEM analysis indicated that silver nanoparticles were incorporated into hydroxyapatite crystal in SDF-treated hydroxyapatite. XPS spectra suggested that the chemical state of the silver was metallic. Significance: The adjunctive application of SDF and NaF varnish had a similar remineralising effect to that of SDF on enamel caries. |
Persistent Identifier | http://hdl.handle.net/10722/266001 |
ISSN | 2023 Impact Factor: 4.6 2023 SCImago Journal Rankings: 1.186 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yu, Y | - |
dc.contributor.author | Mei, L | - |
dc.contributor.author | Zhao, S | - |
dc.contributor.author | Li, QL | - |
dc.contributor.author | Lo, ECM | - |
dc.contributor.author | Chu, CH | - |
dc.date.accessioned | 2018-12-17T02:16:30Z | - |
dc.date.available | 2018-12-17T02:16:30Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Dental Materials, 2018, v. 34 n. 12, p. e344-e352 | - |
dc.identifier.issn | 0109-5641 | - |
dc.identifier.uri | http://hdl.handle.net/10722/266001 | - |
dc.description.abstract | Objective: To evaluate the remineralising effect of the adjunctive application of 38% silver diamine fluoride (SDF) solution and 5% sodium fluoride (NaF) varnish on artificial enamel caries lesions. Methods: Forty-eight demineralised enamel specimens were allocated into four groups. Group 1 received 38% SDF and 5% NaF; Group 2 received 38% SDF; Group 3 received 5% NaF; and Group 4 received deionized water. After pH cycling, the surface morphology and fluoride content of the specimens were studied via scanning electron microscopy (SEM)/energy dispersive spectroscopy (EDS). The lesion depth and crystal characteristics were assessed using micro-computed tomography and X-ray diffraction (XRD) respectively. The crystallization reaction was performed by incubating hydroxyapatite powder with NaF or SDF for 48 h. The precipitates were studied via transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). Results: SEM demonstrated the destruction of the enamel surface in Group 4. EDS revealed that the mean fluoride weight percentage of Groups 1–4 were 1.28 ± 0.15, 1.33 ± 0.19, 1.03 ± 0.09 and 0.87 ± 0.04 respectively. The mean lesion depths of Groups 1–4 were 129 ± 14 μm, 131 ± 16 μm, 153 ± 10 μm and 181 ± 21 μm respectively. The addition of NaF to SDF did not reduce the lesion depths (p = 0.779). XRD revealed that silver chloride formed as a main product in Groups 1 and 2. Meanwhile, TEM analysis indicated that silver nanoparticles were incorporated into hydroxyapatite crystal in SDF-treated hydroxyapatite. XPS spectra suggested that the chemical state of the silver was metallic. Significance: The adjunctive application of SDF and NaF varnish had a similar remineralising effect to that of SDF on enamel caries. | - |
dc.language | eng | - |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/dental | - |
dc.relation.ispartof | Dental Materials | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Caries | - |
dc.subject | Demineralisation | - |
dc.subject | Enamel | - |
dc.subject | Remineralisation | - |
dc.subject | Silver diamine fluoride | - |
dc.title | Remineralisation of enamel with silver diamine fluoride and sodium fluoride | - |
dc.type | Article | - |
dc.identifier.email | Mei, L: mei1123@hku.hk | - |
dc.identifier.email | Lo, ECM: edward-lo@hku.hk | - |
dc.identifier.email | Chu, CH: chchu@hku.hk | - |
dc.identifier.authority | Mei, L=rp01840 | - |
dc.identifier.authority | Lo, ECM=rp00015 | - |
dc.identifier.authority | Chu, CH=rp00022 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1016/j.dental.2018.10.007 | - |
dc.identifier.pmid | 30482611 | - |
dc.identifier.scopus | eid_2-s2.0-85055503356 | - |
dc.identifier.hkuros | 296376 | - |
dc.identifier.hkuros | 330212 | - |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | e344 | - |
dc.identifier.epage | e352 | - |
dc.identifier.isi | WOS:000451619700004 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 0109-5641 | - |