File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Multiband spectral-spatial RF excitation for hyperpolarized [2-13C]dihydroxyacetone13C-MR metabolism studies

TitleMultiband spectral-spatial RF excitation for hyperpolarized [2-13C]dihydroxyacetone13C-MR metabolism studies
Authors
Keywordsspectral-spatial RF pulses
hyperpolarization
dynamic nuclear polarization
kidney
dihydroxyacetone
liver
metabolic imaging
multiband RF pulses
Issue Date2017
Citation
Magnetic Resonance in Medicine, 2017, v. 77, n. 4, p. 1419-1428 How to Cite?
Abstract© 2016 International Society for Magnetic Resonance in Medicine Purpose: To develop a specialized multislice, single-acquisition approach to detect the metabolites of hyperpolarized (HP) [2-13C]dihydroxyacetone (DHAc) to probe gluconeogenesis in vivo, which have a broad 144 ppm spectral range (∼4.6 kHz at 3T). A novel multiband radio-frequency (RF) excitation pulse was designed for independent flip angle control over five to six spectral-spatial (SPSP) excitation bands, each corrected for chemical shift misregistration effects. Methods: Specialized multiband SPSP RF pulses were designed, tested, and applied to investigate HP [2-13C]DHAc metabolism in kidney and liver of fasted rats with dynamic13C-MR spectroscopy and an optimal flip angle scheme. For comparison, experiments were also performed with narrow-band slice-selective RF pulses and a sequential change of the frequency offset to cover the five frequency bands of interest. Results: The SPSP pulses provided a controllable spectral profile free of baseline distortion with improved signal to noise of the metabolite peaks, allowing for quantification of the metabolic products. We observed organ-specific differences in DHAc metabolism. There was two to five times more [2-13C]phosphoenolpyruvate and about 19 times more [2-13C]glycerol 3-phosphate in the liver than in the kidney. Conclusion: A multiband SPSP RF pulse covering a spectral range over 144 ppm enabled in vivo characterization of HP [2-13C]DHAc metabolism in rat liver and kidney. Magn Reson Med 77:1419–1428, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/265691
ISSN
2023 Impact Factor: 3.0
2023 SCImago Journal Rankings: 1.343
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMarco-Rius, Irene-
dc.contributor.authorCao, Peng-
dc.contributor.authorvon Morze, Cornelius-
dc.contributor.authorMerritt, Matthew-
dc.contributor.authorMoreno, Karlos X.-
dc.contributor.authorChang, Gene Yuan-
dc.contributor.authorOhliger, Michael A.-
dc.contributor.authorPearce, David-
dc.contributor.authorKurhanewicz, John-
dc.contributor.authorLarson, Peder E.Z.-
dc.contributor.authorVigneron, Daniel B.-
dc.date.accessioned2018-12-03T01:21:24Z-
dc.date.available2018-12-03T01:21:24Z-
dc.date.issued2017-
dc.identifier.citationMagnetic Resonance in Medicine, 2017, v. 77, n. 4, p. 1419-1428-
dc.identifier.issn0740-3194-
dc.identifier.urihttp://hdl.handle.net/10722/265691-
dc.description.abstract© 2016 International Society for Magnetic Resonance in Medicine Purpose: To develop a specialized multislice, single-acquisition approach to detect the metabolites of hyperpolarized (HP) [2-13C]dihydroxyacetone (DHAc) to probe gluconeogenesis in vivo, which have a broad 144 ppm spectral range (∼4.6 kHz at 3T). A novel multiband radio-frequency (RF) excitation pulse was designed for independent flip angle control over five to six spectral-spatial (SPSP) excitation bands, each corrected for chemical shift misregistration effects. Methods: Specialized multiband SPSP RF pulses were designed, tested, and applied to investigate HP [2-13C]DHAc metabolism in kidney and liver of fasted rats with dynamic13C-MR spectroscopy and an optimal flip angle scheme. For comparison, experiments were also performed with narrow-band slice-selective RF pulses and a sequential change of the frequency offset to cover the five frequency bands of interest. Results: The SPSP pulses provided a controllable spectral profile free of baseline distortion with improved signal to noise of the metabolite peaks, allowing for quantification of the metabolic products. We observed organ-specific differences in DHAc metabolism. There was two to five times more [2-13C]phosphoenolpyruvate and about 19 times more [2-13C]glycerol 3-phosphate in the liver than in the kidney. Conclusion: A multiband SPSP RF pulse covering a spectral range over 144 ppm enabled in vivo characterization of HP [2-13C]DHAc metabolism in rat liver and kidney. Magn Reson Med 77:1419–1428, 2017. © 2016 International Society for Magnetic Resonance in Medicine.-
dc.languageeng-
dc.relation.ispartofMagnetic Resonance in Medicine-
dc.subjectspectral-spatial RF pulses-
dc.subjecthyperpolarization-
dc.subjectdynamic nuclear polarization-
dc.subjectkidney-
dc.subjectdihydroxyacetone-
dc.subjectliver-
dc.subjectmetabolic imaging-
dc.subjectmultiband RF pulses-
dc.titleMultiband spectral-spatial RF excitation for hyperpolarized [2-13C]dihydroxyacetone13C-MR metabolism studies-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mrm.26226-
dc.identifier.pmid27017966-
dc.identifier.scopuseid_2-s2.0-84962332789-
dc.identifier.volume77-
dc.identifier.issue4-
dc.identifier.spage1419-
dc.identifier.epage1428-
dc.identifier.eissn1522-2594-
dc.identifier.isiWOS:000398085200005-
dc.identifier.issnl0740-3194-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats