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- Publisher Website: 10.1039/c4bm00024b
- Scopus: eid_2-s2.0-84900325581
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Article: Designing nanoparticle carriers for enhanced drug efficacy in photodynamic therapy
Title | Designing nanoparticle carriers for enhanced drug efficacy in photodynamic therapy |
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Authors | |
Issue Date | 2014 |
Citation | Biomaterials Science, 2014, v. 2, n. 6, p. 827-832 How to Cite? |
Abstract | Although nanoparticles (NPs) have been proposed as carriers for photosensitizers (PS) in photodynamic therapy (PDT), how the design parameters of nanocarriers affect the final drug efficacy remains unclear. By designing SiO2-PS NPs with specific features (such as enabling easy release of PS from the nanocarriers, or introducing plasmonic Au NPs in the vicinity of the PS), and comparing the respective efficacy of PS to that of the conventional dense SiO2-PS NPs (PS were tightly confined into the silica matrix), we identified that both PS trapping-in/releasing from the silica nanocarriers and the Au plasmonic effect were responsible for the PS efficacy variation. The mechanistic study also disclosed that the different NP configurations would affect the cellular death pathway. These findings provide a general guideline for the design of NP-based PDT applications. This journal is © the Partner Organisations 2014. |
Persistent Identifier | http://hdl.handle.net/10722/265671 |
ISSN | 2023 Impact Factor: 5.8 2023 SCImago Journal Rankings: 1.206 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chu, Zhiqin | - |
dc.contributor.author | Zhang, Silu | - |
dc.contributor.author | Yin, Chun | - |
dc.contributor.author | Lin, Ge | - |
dc.contributor.author | Li, Quan | - |
dc.date.accessioned | 2018-12-03T01:21:20Z | - |
dc.date.available | 2018-12-03T01:21:20Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Biomaterials Science, 2014, v. 2, n. 6, p. 827-832 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265671 | - |
dc.description.abstract | Although nanoparticles (NPs) have been proposed as carriers for photosensitizers (PS) in photodynamic therapy (PDT), how the design parameters of nanocarriers affect the final drug efficacy remains unclear. By designing SiO2-PS NPs with specific features (such as enabling easy release of PS from the nanocarriers, or introducing plasmonic Au NPs in the vicinity of the PS), and comparing the respective efficacy of PS to that of the conventional dense SiO2-PS NPs (PS were tightly confined into the silica matrix), we identified that both PS trapping-in/releasing from the silica nanocarriers and the Au plasmonic effect were responsible for the PS efficacy variation. The mechanistic study also disclosed that the different NP configurations would affect the cellular death pathway. These findings provide a general guideline for the design of NP-based PDT applications. This journal is © the Partner Organisations 2014. | - |
dc.language | eng | - |
dc.relation.ispartof | Biomaterials Science | - |
dc.title | Designing nanoparticle carriers for enhanced drug efficacy in photodynamic therapy | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/c4bm00024b | - |
dc.identifier.scopus | eid_2-s2.0-84900325581 | - |
dc.identifier.volume | 2 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 827 | - |
dc.identifier.epage | 832 | - |
dc.identifier.eissn | 2047-4849 | - |
dc.identifier.isi | WOS:000335984000003 | - |
dc.identifier.issnl | 2047-4830 | - |