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Article: Physiological pathway of human cell damage induced by genotoxic crystalline silica nanoparticles

TitlePhysiological pathway of human cell damage induced by genotoxic crystalline silica nanoparticles
Authors
KeywordsP53
Silica nanoparticles
DNA damage
Mitochondrion multiplication
ROS generation
Issue Date2012
Citation
Biomaterials, 2012, v. 33, n. 30, p. 7540-7546 How to Cite?
AbstractWe disclosed a specific biological pathway for the observed cell damage when stimulated by the crystalline SiO2 nanoparticles (NPs), i.e., both mitochondrion multiplication and DNA fragmentation occur upon the initial reactive oxygen species (ROS) generation, with the former causing further increases of the ROS level in the cell, and eventually leads to catastrophic effect on cell physiology. Such damage becomes nontrivial only in the absence of p53 gene, which regulates cells' anti-oxidation and detoxification. This genotoxic effect is absent in cells treated with amorphous SiO2 NPs. © 2012 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/265628
ISSN
2020 Impact Factor: 12.479
2020 SCImago Journal Rankings: 3.209
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChu, Zhiqin-
dc.contributor.authorHuang, Yuanjie-
dc.contributor.authorLi, Lili-
dc.contributor.authorTao, Qian-
dc.contributor.authorLi, Quan-
dc.date.accessioned2018-12-03T01:21:13Z-
dc.date.available2018-12-03T01:21:13Z-
dc.date.issued2012-
dc.identifier.citationBiomaterials, 2012, v. 33, n. 30, p. 7540-7546-
dc.identifier.issn0142-9612-
dc.identifier.urihttp://hdl.handle.net/10722/265628-
dc.description.abstractWe disclosed a specific biological pathway for the observed cell damage when stimulated by the crystalline SiO2 nanoparticles (NPs), i.e., both mitochondrion multiplication and DNA fragmentation occur upon the initial reactive oxygen species (ROS) generation, with the former causing further increases of the ROS level in the cell, and eventually leads to catastrophic effect on cell physiology. Such damage becomes nontrivial only in the absence of p53 gene, which regulates cells' anti-oxidation and detoxification. This genotoxic effect is absent in cells treated with amorphous SiO2 NPs. © 2012 Elsevier Ltd.-
dc.languageeng-
dc.relation.ispartofBiomaterials-
dc.subjectP53-
dc.subjectSilica nanoparticles-
dc.subjectDNA damage-
dc.subjectMitochondrion multiplication-
dc.subjectROS generation-
dc.titlePhysiological pathway of human cell damage induced by genotoxic crystalline silica nanoparticles-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biomaterials.2012.06.073-
dc.identifier.pmid22795858-
dc.identifier.scopuseid_2-s2.0-84865026006-
dc.identifier.volume33-
dc.identifier.issue30-
dc.identifier.spage7540-
dc.identifier.epage7546-
dc.identifier.eissn1878-5905-
dc.identifier.isiWOS:000308524000023-
dc.identifier.issnl0142-9612-

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