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Article: Cellular uptake, evolution, and excretion of silica nanoparticles in human cells

TitleCellular uptake, evolution, and excretion of silica nanoparticles in human cells
Authors
Issue Date2011
Citation
Nanoscale, 2011, v. 3, n. 8, p. 3291-3299 How to Cite?
AbstractA systematic study on the interaction of silica nanoparticles (NPs) with human cells has been carried out in the present work. Endocytosis and exocytosis are identified as major pathways for NPs entering, and exiting the cells, respectively. Most of the NPs are found to be enclosed in membrane bounded organelles, which are fairly stable (against rupture) as very few NPs are released into the cytoplasm. The nanoparticle-cell interaction is a dynamic process, and the amount of NPs inside the cells is affected by both the amount and morphology (degree of aggregation) of NPs in the medium. These interaction characteristics determine the low cytotoxicity of SiO2 NPs at low feeding concentration. © 2011 The Royal Society of Chemistry.
Persistent Identifierhttp://hdl.handle.net/10722/265606
ISSN
2020 Impact Factor: 7.79
2020 SCImago Journal Rankings: 2.038
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChu, Zhiqin-
dc.contributor.authorHuang, Yuanjie-
dc.contributor.authorTao, Qian-
dc.contributor.authorLi, Quan-
dc.date.accessioned2018-12-03T01:21:09Z-
dc.date.available2018-12-03T01:21:09Z-
dc.date.issued2011-
dc.identifier.citationNanoscale, 2011, v. 3, n. 8, p. 3291-3299-
dc.identifier.issn2040-3364-
dc.identifier.urihttp://hdl.handle.net/10722/265606-
dc.description.abstractA systematic study on the interaction of silica nanoparticles (NPs) with human cells has been carried out in the present work. Endocytosis and exocytosis are identified as major pathways for NPs entering, and exiting the cells, respectively. Most of the NPs are found to be enclosed in membrane bounded organelles, which are fairly stable (against rupture) as very few NPs are released into the cytoplasm. The nanoparticle-cell interaction is a dynamic process, and the amount of NPs inside the cells is affected by both the amount and morphology (degree of aggregation) of NPs in the medium. These interaction characteristics determine the low cytotoxicity of SiO2 NPs at low feeding concentration. © 2011 The Royal Society of Chemistry.-
dc.languageeng-
dc.relation.ispartofNanoscale-
dc.titleCellular uptake, evolution, and excretion of silica nanoparticles in human cells-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/c1nr10499c-
dc.identifier.pmid21743927-
dc.identifier.scopuseid_2-s2.0-80051585527-
dc.identifier.volume3-
dc.identifier.issue8-
dc.identifier.spage3291-
dc.identifier.epage3299-
dc.identifier.eissn2040-3372-
dc.identifier.isiWOS:000293521700045-
dc.identifier.issnl2040-3364-

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