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- Publisher Website: 10.1080/14756360802319678
- Scopus: eid_2-s2.0-70749145955
- PMID: 18671164
- WOS: WOS:000266040700002
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Article: Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells
Title | Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells |
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Authors | |
Keywords | Catechins Fatty acid synthase Inhibitor Oligomers Anticancer activity |
Issue Date | 2009 |
Citation | Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, v. 24, n. 3, p. 623-631 How to Cite? |
Abstract | Fatty acid synthase (FAS) is a potential target for cancer, but potent inhibitors against FAS are scarce. In this study, we found that activities of catechins on inhibiting FAS increased greatly by heating them in acid. The enhancement was positively correlated to H concentration. The inhibitory activities of the final products from different catechins were similar, all of which were less than 1 μg/mL. The product from ( - )-epigallocatechin gallate (EGCG) was stable at room temperature, and its inhibitory kinetics and reacting sites on FAS were obviously different from the known FAS inhibitors. It also affected the viability of MCF-7 cells more obviously than EGCG. A putative route of the reaction progress was proposed and the effective inhibitors were deduced to be oligomers of 2-hydroxy-3-(3′, 4′, 5′-trihydroxyphenyl) propenoic acid by analysis of their spectra. The work affords new and potent FAS inhibitors that would be promising candidates for the treatment of cancer. © 2009 Informa UK Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/265573 |
ISSN | 2023 Impact Factor: 5.6 2023 SCImago Journal Rankings: 0.949 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhang, Shu Yan | - |
dc.contributor.author | Ma, Xiao Feng | - |
dc.contributor.author | Zheng, Chao Gu | - |
dc.contributor.author | Wang, Yan | - |
dc.contributor.author | Cao, Xue Li | - |
dc.contributor.author | Tian, Wei Xi | - |
dc.date.accessioned | 2018-12-03T01:21:04Z | - |
dc.date.available | 2018-12-03T01:21:04Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, v. 24, n. 3, p. 623-631 | - |
dc.identifier.issn | 1475-6366 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265573 | - |
dc.description.abstract | Fatty acid synthase (FAS) is a potential target for cancer, but potent inhibitors against FAS are scarce. In this study, we found that activities of catechins on inhibiting FAS increased greatly by heating them in acid. The enhancement was positively correlated to H concentration. The inhibitory activities of the final products from different catechins were similar, all of which were less than 1 μg/mL. The product from ( - )-epigallocatechin gallate (EGCG) was stable at room temperature, and its inhibitory kinetics and reacting sites on FAS were obviously different from the known FAS inhibitors. It also affected the viability of MCF-7 cells more obviously than EGCG. A putative route of the reaction progress was proposed and the effective inhibitors were deduced to be oligomers of 2-hydroxy-3-(3′, 4′, 5′-trihydroxyphenyl) propenoic acid by analysis of their spectra. The work affords new and potent FAS inhibitors that would be promising candidates for the treatment of cancer. © 2009 Informa UK Ltd. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Enzyme Inhibition and Medicinal Chemistry | - |
dc.subject | Catechins | - |
dc.subject | Fatty acid synthase | - |
dc.subject | Inhibitor | - |
dc.subject | Oligomers | - |
dc.subject | Anticancer activity | - |
dc.title | Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 cells | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1080/14756360802319678 | - |
dc.identifier.pmid | 18671164 | - |
dc.identifier.scopus | eid_2-s2.0-70749145955 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 623 | - |
dc.identifier.epage | 631 | - |
dc.identifier.eissn | 1475-6374 | - |
dc.identifier.isi | WOS:000266040700002 | - |
dc.identifier.issnl | 1475-6366 | - |