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Article: Progress in epigenetic regulation of V(D)J recombination
Title | Progress in epigenetic regulation of V(D)J recombination |
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Authors | |
Keywords | Chromatin remodeling ACEs Epigenetics Histone modification RAG accessibility V (D)J recombination |
Issue Date | 2008 |
Citation | Progress in Biochemistry and Biophysics, 2008, v. 35, n. 2, p. 133-142 How to Cite? |
Abstract | During lymphocyte development antigen receptor genes undergo V (D)J recombination to obtain antigen binding specificity and diversity. This process is not only controlled by genetic factors, such as tissue- and stage- specificity of RAG-1/2 protein, germline transcriptional activity and ACEs, but also regulated at epigenetic level. The chromatin accessibility of recombinase is associated with the chromatin configuration around the targeted gene segments. Thus, activation of V (D)J recombination requires the recruitment of remodeling complexes for changing the accessibility in the localized chromatin. Moreover, docking of remodeling complexes, which serve for creating active chromatin environment, relies on certain patterns of chromatin modification. Some recent findings regarding epigenetic regulation mechanisms in V(D)J recombination, such as CpG methylation, histone modification, nucleosome remodeling and nuclear topology were reviewed. |
Persistent Identifier | http://hdl.handle.net/10722/265540 |
ISSN | 2023 Impact Factor: 0.2 2023 SCImago Journal Rankings: 0.125 |
DC Field | Value | Language |
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dc.contributor.author | Zheng, Chao Gu | - |
dc.contributor.author | Yan, Xi Yun | - |
dc.date.accessioned | 2018-12-03T01:20:58Z | - |
dc.date.available | 2018-12-03T01:20:58Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Progress in Biochemistry and Biophysics, 2008, v. 35, n. 2, p. 133-142 | - |
dc.identifier.issn | 1000-3282 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265540 | - |
dc.description.abstract | During lymphocyte development antigen receptor genes undergo V (D)J recombination to obtain antigen binding specificity and diversity. This process is not only controlled by genetic factors, such as tissue- and stage- specificity of RAG-1/2 protein, germline transcriptional activity and ACEs, but also regulated at epigenetic level. The chromatin accessibility of recombinase is associated with the chromatin configuration around the targeted gene segments. Thus, activation of V (D)J recombination requires the recruitment of remodeling complexes for changing the accessibility in the localized chromatin. Moreover, docking of remodeling complexes, which serve for creating active chromatin environment, relies on certain patterns of chromatin modification. Some recent findings regarding epigenetic regulation mechanisms in V(D)J recombination, such as CpG methylation, histone modification, nucleosome remodeling and nuclear topology were reviewed. | - |
dc.language | eng | - |
dc.relation.ispartof | Progress in Biochemistry and Biophysics | - |
dc.subject | Chromatin remodeling | - |
dc.subject | ACEs | - |
dc.subject | Epigenetics | - |
dc.subject | Histone modification | - |
dc.subject | RAG accessibility | - |
dc.subject | V (D)J recombination | - |
dc.title | Progress in epigenetic regulation of V(D)J recombination | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.scopus | eid_2-s2.0-44449085328 | - |
dc.identifier.volume | 35 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 133 | - |
dc.identifier.epage | 142 | - |
dc.identifier.issnl | 1000-3282 | - |