File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1038/srep11661
- Scopus: eid_2-s2.0-84934784026
- PMID: 26123532
- WOS: WOS:000357104500001
Supplementary
- Citations:
- Appears in Collections:
Article: Rapid endosomal escape of prickly nanodiamonds: Implications for gene delivery
Title | Rapid endosomal escape of prickly nanodiamonds: Implications for gene delivery |
---|---|
Authors | |
Issue Date | 2015 |
Citation | Scientific Reports, 2015, v. 5 How to Cite? |
Abstract | The prickly nanodiamonds easily entered cells via endocytosis followed by unique intracellular translocation characteristics - quick endosomal escape followed by stable residence in cytoplasm. Endosomal membrane rupturing is identified as the major route of nanodiamonds' escaping the vesicle confinement and to the cytoplasm. Little cytotoxicity is observed to associate with the nanodiamonds' cytosolic release. Such features enable its application for gene delivery, which requires both effective cellular uptake and cytosolic release of the gene. Taking green fluorescent protein gene as an example, we demonstrate the successful cytosolic delivery and expression of such a gene using the prickly nanodiamonds as carrier. |
Persistent Identifier | http://hdl.handle.net/10722/265434 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chu, Zhiqin | - |
dc.contributor.author | Miu, Kaikei | - |
dc.contributor.author | Lung, Pingsai | - |
dc.contributor.author | Zhang, Silu | - |
dc.contributor.author | Zhao, Saisai | - |
dc.contributor.author | Chang, Huan Cheng | - |
dc.contributor.author | Lin, Ge | - |
dc.contributor.author | Li, Quan | - |
dc.date.accessioned | 2018-12-03T01:20:39Z | - |
dc.date.available | 2018-12-03T01:20:39Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Scientific Reports, 2015, v. 5 | - |
dc.identifier.uri | http://hdl.handle.net/10722/265434 | - |
dc.description.abstract | The prickly nanodiamonds easily entered cells via endocytosis followed by unique intracellular translocation characteristics - quick endosomal escape followed by stable residence in cytoplasm. Endosomal membrane rupturing is identified as the major route of nanodiamonds' escaping the vesicle confinement and to the cytoplasm. Little cytotoxicity is observed to associate with the nanodiamonds' cytosolic release. Such features enable its application for gene delivery, which requires both effective cellular uptake and cytosolic release of the gene. Taking green fluorescent protein gene as an example, we demonstrate the successful cytosolic delivery and expression of such a gene using the prickly nanodiamonds as carrier. | - |
dc.language | eng | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Rapid endosomal escape of prickly nanodiamonds: Implications for gene delivery | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/srep11661 | - |
dc.identifier.pmid | 26123532 | - |
dc.identifier.scopus | eid_2-s2.0-84934784026 | - |
dc.identifier.volume | 5 | - |
dc.identifier.spage | null | - |
dc.identifier.epage | null | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.isi | WOS:000357104500001 | - |
dc.identifier.issnl | 2045-2322 | - |