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Article: Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer

TitleRates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer
Authors
KeywordsColon neoplasms
Colonoscopy
Curative colectomy
Follow up
Recurrence
Issue Date2018
PublisherKorean Association for the Study of Intestinal Diseases. The Journal's web site is located at http://www.irjournal.org/
Citation
Intestinal Research, 2018, v. 16 n. 4, p. 619-627 How to Cite?
AbstractBackground/Aims: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. Methods: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonoscopy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis. Results: Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37–0.68 vs. 0.22; 95% CI, 0.08–0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy. Conclusions: Patients with Lsided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonoscopy.
Persistent Identifierhttp://hdl.handle.net/10722/265276
ISSN
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 0.993
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLam, YF-
dc.contributor.authorSeto, WKW-
dc.contributor.authorTong, SM-
dc.contributor.authorCheung, KSM-
dc.contributor.authorLo, OSH-
dc.contributor.authorHung, FNI-
dc.contributor.authorLaw, WL-
dc.contributor.authorLeung, WK-
dc.date.accessioned2018-11-20T02:03:30Z-
dc.date.available2018-11-20T02:03:30Z-
dc.date.issued2018-
dc.identifier.citationIntestinal Research, 2018, v. 16 n. 4, p. 619-627-
dc.identifier.issn1598-9100-
dc.identifier.urihttp://hdl.handle.net/10722/265276-
dc.description.abstractBackground/Aims: We determined the rates of metachronous colorectal neoplasm in colorectal cancer (CRC) patients after resection for right (R)-sided or left (L)-sided cancer. Methods: Consecutive CRC patients who had undergone surgical resection for curative intent in our hospital between 2001 and 2004 were identified. R-sided colonic cancers refer to cancer proximal to splenic flexure whereas L-sided cancers include rectal cancers. Patients were included only if they had a clearing colonoscopy performed either before or within 6 months after the operation. Findings of surveillance colonoscopy performed up to 5 years after colonic resection were included in the analysis. Results: Eight hundred and sixty-three CRC patients underwent curative surgical resection during the study period. Three hundred and twenty-seven patients (107 R-sided and 220 L-sided) fulfilled the inclusion criteria and had at least 1 postoperative surveillance colonoscopy performed. The proportion of patients who had polyp and adenoma on surveillance colonoscopy was significantly higher among patients with L-sided than R-sided cancers (polyps: 30.9% vs. 19.6%, P=0.03; adenomas: 25.5% vs. 13.1%, P=0.01). The mean number of adenoma per patient on surveillance colonoscopy was also higher for patients with L-sided than R-sided tumors (0.52; 95% confidence interval [CI], 0.37–0.68 vs. 0.22; 95% CI, 0.08–0.35; P<0.01). Multivariate analysis showed that L-sided cancers, age, male gender and longer follow-up were independent predictors of adenoma detection on surveillance colonoscopy. Conclusions: Patients with Lsided cancer had a higher rate of metachronous polyps and adenoma than those with R-sided cancer on surveillance colonoscopy.-
dc.languageeng-
dc.publisherKorean Association for the Study of Intestinal Diseases. The Journal's web site is located at http://www.irjournal.org/-
dc.relation.ispartofIntestinal Research-
dc.rightsIntestinal Research. Copyright © 2018 Korean Association for the Study of Intestinal Diseases.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectColon neoplasms-
dc.subjectColonoscopy-
dc.subjectCurative colectomy-
dc.subjectFollow up-
dc.subjectRecurrence-
dc.titleRates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer-
dc.typeArticle-
dc.identifier.emailLam, YF: fyflam@hku.hk-
dc.identifier.emailSeto, WKW: wkseto@hku.hk-
dc.identifier.emailTong, SM: tongsma@hkucc.hku.hk-
dc.identifier.emailCheung, KSM: cks634@hku.hk-
dc.identifier.emailLo, OSH: oswens@hku.hk-
dc.identifier.emailHung, FNI: ivanhung@hkucc.hku.hk-
dc.identifier.emailLaw, WL: lawwl@hkucc.hku.hk-
dc.identifier.emailLeung, WK: waikleung@hku.hk-
dc.identifier.authoritySeto, WKW=rp01659-
dc.identifier.authorityCheung, KSM=rp02532-
dc.identifier.authorityHung, FNI=rp00508-
dc.identifier.authorityLaw, WL=rp00436-
dc.identifier.authorityLeung, WK=rp01479-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5217/ir.2018.00013-
dc.identifier.pmid30301327-
dc.identifier.pmcidPMC6223457-
dc.identifier.scopuseid_2-s2.0-85056558757-
dc.identifier.hkuros296072-
dc.identifier.volume16-
dc.identifier.issue4-
dc.identifier.spage619-
dc.identifier.epage627-
dc.identifier.isiWOS:000448626100014-
dc.publisher.placeRepublic of Korea-
dc.identifier.issnl1598-9100-

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