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Article: A single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study

TitleA single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study
Authors
KeywordsMania
Bipolar disorder
Cognition
Early intervention
Lithium
Quetiapine
Issue Date2016
Citation
European Psychiatry, 2016, v. 31, p. 20-28 How to Cite?
Abstract© 2015 Elsevier Masson SAS. Background: Cognitive deficits have been reported during the early stages of bipolar disorder; however, the role of medication on such deficits remains unclear. The aim of this study was to compare the effects of lithium and quetiapine monotherapy on cognitive performance in people following first episode mania. Methods: The design was a single-blind, randomised controlled trial on a cohort of 61 participants following first episode mania. Participants received either lithium or quetiapine monotherapy as maintenance treatment over a 12-month follow-up period. The groups were compared on performance outcomes using an extensive cognitive assessment battery conducted at baseline, month 3 and month 12 follow-up time-points. Results: There was a significant interaction between group and time in phonemic fluency at the 3-month and 12-month endpoints, reflecting greater improvements in performance in lithium-treated participants relative to quetiapine-treated participants. After controlling for multiple comparisons, there were no other significant interactions between group and time for other measures of cognition. Conclusion: Although the effects of lithium and quetiapine treatment were similar for most cognitive domains, the findings imply that early initiation of lithium treatment may benefit the trajectory of cognition, specifically verbal fluency in young people with bipolar disorder. Given that cognition is a major symptomatic domain of bipolar disorder and has substantive effects on general functioning, the ability to influence the trajectory of cognitive change is of considerable clinical importance.
Persistent Identifierhttp://hdl.handle.net/10722/264965
ISSN
2023 Impact Factor: 7.2
2023 SCImago Journal Rankings: 1.901
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorDaglas, R.-
dc.contributor.authorCotton, S. M.-
dc.contributor.authorAllott, K.-
dc.contributor.authorYücel, M.-
dc.contributor.authorMacneil, C. A.-
dc.contributor.authorHasty, M. K.-
dc.contributor.authorMurphy, B.-
dc.contributor.authorPantelis, C.-
dc.contributor.authorHallam, K. T.-
dc.contributor.authorHenry, L. P.-
dc.contributor.authorConus, P.-
dc.contributor.authorRatheesh, A.-
dc.contributor.authorKader, L.-
dc.contributor.authorWong, M. T.H.-
dc.contributor.authorMcGorry, P. D.-
dc.contributor.authorBerk, M.-
dc.date.accessioned2018-11-08T01:35:27Z-
dc.date.available2018-11-08T01:35:27Z-
dc.date.issued2016-
dc.identifier.citationEuropean Psychiatry, 2016, v. 31, p. 20-28-
dc.identifier.issn0924-9338-
dc.identifier.urihttp://hdl.handle.net/10722/264965-
dc.description.abstract© 2015 Elsevier Masson SAS. Background: Cognitive deficits have been reported during the early stages of bipolar disorder; however, the role of medication on such deficits remains unclear. The aim of this study was to compare the effects of lithium and quetiapine monotherapy on cognitive performance in people following first episode mania. Methods: The design was a single-blind, randomised controlled trial on a cohort of 61 participants following first episode mania. Participants received either lithium or quetiapine monotherapy as maintenance treatment over a 12-month follow-up period. The groups were compared on performance outcomes using an extensive cognitive assessment battery conducted at baseline, month 3 and month 12 follow-up time-points. Results: There was a significant interaction between group and time in phonemic fluency at the 3-month and 12-month endpoints, reflecting greater improvements in performance in lithium-treated participants relative to quetiapine-treated participants. After controlling for multiple comparisons, there were no other significant interactions between group and time for other measures of cognition. Conclusion: Although the effects of lithium and quetiapine treatment were similar for most cognitive domains, the findings imply that early initiation of lithium treatment may benefit the trajectory of cognition, specifically verbal fluency in young people with bipolar disorder. Given that cognition is a major symptomatic domain of bipolar disorder and has substantive effects on general functioning, the ability to influence the trajectory of cognitive change is of considerable clinical importance.-
dc.languageeng-
dc.relation.ispartofEuropean Psychiatry-
dc.subjectMania-
dc.subjectBipolar disorder-
dc.subjectCognition-
dc.subjectEarly intervention-
dc.subjectLithium-
dc.subjectQuetiapine-
dc.titleA single-blind, randomised controlled trial on the effects of lithium and quetiapine monotherapy on the trajectory of cognitive functioning in first episode mania: A 12-month follow-up study-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.eurpsy.2015.09.460-
dc.identifier.pmid26655594-
dc.identifier.scopuseid_2-s2.0-84953210811-
dc.identifier.volume31-
dc.identifier.spage20-
dc.identifier.epage28-
dc.identifier.eissn1778-3585-
dc.identifier.isiWOS:000368134400004-
dc.identifier.issnl0924-9338-

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