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Article: The plasma haloperidol and reduced haloperidol concentrations in chinese schizophrenic patients: Relationship between reduced haloperidol/haloperidol ratio and red blood cell haloperidol reductase activity

TitleThe plasma haloperidol and reduced haloperidol concentrations in chinese schizophrenic patients: Relationship between reduced haloperidol/haloperidol ratio and red blood cell haloperidol reductase activity
Authors
Wong, B. Y.M.Chan, Mo‐Yin ‐YWong, M. T.H.Lieh‐Mak, F.
KeywordsHaloperidol
schizophrenic
reduced haloperidol
Issue Date1992
Citation
Human Psychopharmacology: Clinical and Experimental, 1992, v. 7, n. 2, p. 123-128 How to Cite?
DOI: http://dx.doi.org/10.1002/hup.470070207
AbstractFifteen chinese schizophrenic patients were given titrated doses of haloperidol (0.05‐0.42 mg/kg) for two weeks. All these 15 patients were in clinical remission on maintenance dose of haloperidol. The mean plasma haloperidol and reduced haloperidol concentrations were 16.8 ± 4.8 ng/ml and 13.6‐ 5.7 ng/ml respectively. The plasma RHAL/HAL ratio was in the range of 0.13±1.94. These values were similar to that reported for the Japanese population. The frequency distribution appeared to be bimodal. RBC reductase activity were found to be distributed normally and no correlation was found between plasma RHAL/HAL ratio and RBC reductase activity. Copyright © 1992 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/264879
ISSN
0885-6222
2023 Impact Factor: 1.8
2023 SCImago Journal Rankings: 0.541
ISI Accession Number ID
WOS:A1992HT74100006

 

DC FieldValueLanguage
dc.contributor.authorWong, B. Y.M.-
dc.contributor.authorChan, Mo‐Yin ‐Y-
dc.contributor.authorWong, M. T.H.-
dc.contributor.authorLieh‐Mak, F.-
dc.date.accessioned2018-11-08T01:35:10Z-
dc.date.available2018-11-08T01:35:10Z-
dc.date.issued1992-
dc.identifier.citationHuman Psychopharmacology: Clinical and Experimental, 1992, v. 7, n. 2, p. 123-128-
dc.identifier.issn0885-6222-
dc.identifier.urihttp://hdl.handle.net/10722/264879-
dc.description.abstractFifteen chinese schizophrenic patients were given titrated doses of haloperidol (0.05‐0.42 mg/kg) for two weeks. All these 15 patients were in clinical remission on maintenance dose of haloperidol. The mean plasma haloperidol and reduced haloperidol concentrations were 16.8 ± 4.8 ng/ml and 13.6‐ 5.7 ng/ml respectively. The plasma RHAL/HAL ratio was in the range of 0.13±1.94. These values were similar to that reported for the Japanese population. The frequency distribution appeared to be bimodal. RBC reductase activity were found to be distributed normally and no correlation was found between plasma RHAL/HAL ratio and RBC reductase activity. Copyright © 1992 John Wiley & Sons, Ltd.-
dc.languageeng-
dc.relation.ispartofHuman Psychopharmacology: Clinical and Experimental-
dc.subjectHaloperidol-
dc.subjectschizophrenic-
dc.subjectreduced haloperidol-
dc.titleThe plasma haloperidol and reduced haloperidol concentrations in chinese schizophrenic patients: Relationship between reduced haloperidol/haloperidol ratio and red blood cell haloperidol reductase activity-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hup.470070207-
dc.identifier.scopuseid_2-s2.0-0026516183-
dc.identifier.volume7-
dc.identifier.issue2-
dc.identifier.spage123-
dc.identifier.epage128-
dc.identifier.eissn1099-1077-
dc.identifier.isiWOS:A1992HT74100006-
dc.identifier.issnl0885-6222-

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