Therapeutic effects analysis of percutaneous kyphoplasty for osteoporotic vertebral compression fractures: A multicenter study

Abstract

Background Percutaneous kyphoplasty (PKP), a minimally invasive treatment, has been widely used for osteoporotic vertebral compression fractures (OVCFs). Objective To retrospectively analyse the therapeutic effects of PKP using a series of key techniques in a multicentre study. Methods From May 2000 to December 2016, PKP was performed using a series of key techniques (puncture, reduction, and perfusion techniques) for the treatment of 4532 OVCF patients. The pain visual analog scale (VAS) and the Oswestry Disability Index (ODI) questionnaire prior to the operation, at postoperative Day 2, and at the last follow-up were analysed by paired t-test analysis. The leakage of bone cement was evaluated by postoperative radiography and/or computed tomography. Four-year survival was calculated at the last follow-up. Results The average follow-up was 63 months (1–116 months). The VAS score decreased from 8.9 (preoperative) to 2.3 (2 days postoperative) to 1.9 (last follow-up). The ODI score of the patients decreased from 86.7 (preoperative) to 31.6 (2 days postoperative) to 25.3 (last follow-up). Both VAS score and ODI score improved significantly. The bone cement leakage rate was 3.5%, with no clinical symptoms. The 4-year survival rate was 77.5%. Conclusion This study suggests that PKP with key techniques would be an effective technique to treat OVCF with less risk and better therapeutic effect. Such diagnostic methods and surgical techniques lead to the development and progress of treatment for OVCF. The translational potential of this article: PKP with key techniques would be an effective technique to treat and lead to the development and progress of treatment for OVCF.