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Article: Effect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis

TitleEffect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis
Authors
Issue Date2018
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
Hong Kong Medical Journal, 2018, v. 24 n. 5, p. 444-450 How to Cite?
AbstractObjective: To determine the effect of paternal age on semen parameters and the live birth rate from in-vitro fertilisation (IVF) treatment. Methods: We performed a retrospective cohort study of couples undergoing a first IVF cycle between 2004 and 2014 in a tertiary assisted reproduction centre in Hong Kong. Results: We analysed 3549 cases. Paternal age ≥40 years was negatively correlated with semen volume, progressive motility, total motility and total normal motile count (P<0.005) and positively correlated with sperm concentration (P<0.001). There was no correlation with sperm count, normal morphology, or total motile count. Subgroup analyses in Chinese men only and in men with normal versus abnormal semen parameters showed the same correlations. Paternal age was positively associated with maternal age (P<0.001) and miscarriage (P=0.006), and negatively associated with ongoing pregnancy and live birth (P<0.001). Logistic regression showed that maternal age, total number of oocytes retrieved, and number of embryos transferred were significant factors which independently predicted the likelihood of live birth from IVF (all P<0.001). Conclusion: Paternal age was negatively correlated with some semen parameters, which showed a significant decline after age 40 years. However, paternal age is not predictive of the live birth from IVF treatment.
Persistent Identifierhttp://hdl.handle.net/10722/263482
ISSN
2023 Impact Factor: 3.1
2023 SCImago Journal Rankings: 0.261
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLai, SF-
dc.contributor.authorLi, RHW-
dc.contributor.authorYeung, WSB-
dc.contributor.authorNg, EHY-
dc.date.accessioned2018-10-22T07:39:40Z-
dc.date.available2018-10-22T07:39:40Z-
dc.date.issued2018-
dc.identifier.citationHong Kong Medical Journal, 2018, v. 24 n. 5, p. 444-450-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/263482-
dc.description.abstractObjective: To determine the effect of paternal age on semen parameters and the live birth rate from in-vitro fertilisation (IVF) treatment. Methods: We performed a retrospective cohort study of couples undergoing a first IVF cycle between 2004 and 2014 in a tertiary assisted reproduction centre in Hong Kong. Results: We analysed 3549 cases. Paternal age ≥40 years was negatively correlated with semen volume, progressive motility, total motility and total normal motile count (P<0.005) and positively correlated with sperm concentration (P<0.001). There was no correlation with sperm count, normal morphology, or total motile count. Subgroup analyses in Chinese men only and in men with normal versus abnormal semen parameters showed the same correlations. Paternal age was positively associated with maternal age (P<0.001) and miscarriage (P=0.006), and negatively associated with ongoing pregnancy and live birth (P<0.001). Logistic regression showed that maternal age, total number of oocytes retrieved, and number of embryos transferred were significant factors which independently predicted the likelihood of live birth from IVF (all P<0.001). Conclusion: Paternal age was negatively correlated with some semen parameters, which showed a significant decline after age 40 years. However, paternal age is not predictive of the live birth from IVF treatment.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleEffect of paternal age on semen parameters and live birth rate of in-vitro fertilisation treatment: a retrospective analysis-
dc.typeArticle-
dc.identifier.emailLai, SF: laisf@hku.hk-
dc.identifier.emailLi, RHW: raymondli@hku.hk-
dc.identifier.emailYeung, WSB: wsbyeung@hku.hk-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.authorityLi, RHW=rp01649-
dc.identifier.authorityYeung, WSB=rp00331-
dc.identifier.authorityNg, EHY=rp00426-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.12809/hkmj177111-
dc.identifier.scopuseid_2-s2.0-85055080464-
dc.identifier.hkuros295766-
dc.identifier.volume24-
dc.identifier.issue5-
dc.identifier.spage444-
dc.identifier.epage450-
dc.identifier.isiWOS:000448268400003-
dc.publisher.placeHong Kong-
dc.identifier.issnl1024-2708-

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