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Article: Network modelling of gene regulation
Title | Network modelling of gene regulation |
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Authors | |
Keywords | Gene regulatory network Systems biology Bioinformatics |
Issue Date | 2011 |
Citation | Biophysical Reviews, 2011, v. 3, n. 1, p. 1-13 How to Cite? |
Abstract | Gene regulatory network (GRN) modelling has gained increasing attention in the past decade. Many computational modelling techniques have been proposed to facilitate the inference and analysis of GRN. However, there is often confusion about the aim of GRN modelling, and how a gene network model can be fully utilised as a tool for systems biology. The aim of the present article is to provide an overview of this rapidly expanding subject. In particular, we review some fundamental concepts of systems biology and discuss the role of network modelling in understanding complex biological systems. Several commonly used network modelling paradigms are surveyed with emphasis on their practical use in systems biology research. © 2010 International Union for Pure and Applied Biophysics (IUPAB) and Springer. |
Persistent Identifier | http://hdl.handle.net/10722/262605 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.145 |
DC Field | Value | Language |
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dc.contributor.author | Ho, Joshua W.K. | - |
dc.contributor.author | Charleston, Michael A. | - |
dc.date.accessioned | 2018-10-08T02:46:31Z | - |
dc.date.available | 2018-10-08T02:46:31Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | Biophysical Reviews, 2011, v. 3, n. 1, p. 1-13 | - |
dc.identifier.issn | 1867-2450 | - |
dc.identifier.uri | http://hdl.handle.net/10722/262605 | - |
dc.description.abstract | Gene regulatory network (GRN) modelling has gained increasing attention in the past decade. Many computational modelling techniques have been proposed to facilitate the inference and analysis of GRN. However, there is often confusion about the aim of GRN modelling, and how a gene network model can be fully utilised as a tool for systems biology. The aim of the present article is to provide an overview of this rapidly expanding subject. In particular, we review some fundamental concepts of systems biology and discuss the role of network modelling in understanding complex biological systems. Several commonly used network modelling paradigms are surveyed with emphasis on their practical use in systems biology research. © 2010 International Union for Pure and Applied Biophysics (IUPAB) and Springer. | - |
dc.language | eng | - |
dc.relation.ispartof | Biophysical Reviews | - |
dc.subject | Gene regulatory network | - |
dc.subject | Systems biology | - |
dc.subject | Bioinformatics | - |
dc.title | Network modelling of gene regulation | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s12551-010-0041-4 | - |
dc.identifier.scopus | eid_2-s2.0-84873199381 | - |
dc.identifier.volume | 3 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 13 | - |
dc.identifier.eissn | 1867-2469 | - |
dc.identifier.issnl | 1867-2450 | - |