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Article: Circulating Adipocyte Fatty Acid-Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes

TitleCirculating Adipocyte Fatty Acid-Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes
Authors
Issue Date2018
PublisherOxford University Press. The Journal's web site is located at http://www.clinchem.org
Citation
Clinical Chemistry, 2018, v. 64 n. 10, p. 1496-1504 How to Cite?
AbstractINTRODUCTION Raised circulating adipocyte fatty acid–binding protein (AFABP) concentrations are associated with various adverse health conditions. However, their relationship with mortality remains to be defined, especially in view of the sexual dimorphism of circulating AFABP concentrations. Here we investigated prospectively whether serum AFABP concentrations predict multiple mortality outcomes in men and women alike, using a large clinic-based cohort of individuals with type 2 diabetes, a condition with raised AFABP concentrations. METHODS Baseline serum AFABP concentrations were measured in 5305 research participants with a monoclonal antibody-based sandwich immunoassay. The role of circulating AFABP concentrations in predicting mortality outcomes was evaluated by multivariable Cox regression analysis. RESULTS Among the 5305 participants (59% men) in this study, over a median follow-up of 5 years, there were 512 deaths (19.3 deaths per 1000 person-years). Circulating AFABP concentrations, with higher levels in women at baseline, predicted all-cause mortality (P < 0.001), cardiovascular mortality (P = 0.037), and infection-related deaths (P < 0.002) among all participants. In sex-specific analyses, circulating AFABP concentration was an independent predictor of all-cause mortality in both men and women and a predictor of cancer-related deaths and infection-related deaths in men only. Furthermore, the addition of serum AFABP concentrations improved the time-dependent c statistics in predicting all-cause mortality in participants with type 2 diabetes (P = 0.008). CONCLUSIONS Circulating AFABP concentration was an independent predictor of various mortality outcomes in type 2 diabetes over and above known risk factors of reduced survival in men and women. The role of AFABP as a prognostic biomarker and therapeutic target warrants further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/262361
ISSN
2021 Impact Factor: 12.167
2020 SCImago Journal Rankings: 1.705
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, CH-
dc.contributor.authorCheung, CYY-
dc.contributor.authorWoo, YC-
dc.contributor.authorLui, DTW-
dc.contributor.authorYuen, MMA-
dc.contributor.authorFong, CHY-
dc.contributor.authorChow, WS-
dc.contributor.authorXu, A-
dc.contributor.authorLam, KSL-
dc.date.accessioned2018-09-28T04:58:00Z-
dc.date.available2018-09-28T04:58:00Z-
dc.date.issued2018-
dc.identifier.citationClinical Chemistry, 2018, v. 64 n. 10, p. 1496-1504-
dc.identifier.issn0009-9147-
dc.identifier.urihttp://hdl.handle.net/10722/262361-
dc.description.abstractINTRODUCTION Raised circulating adipocyte fatty acid–binding protein (AFABP) concentrations are associated with various adverse health conditions. However, their relationship with mortality remains to be defined, especially in view of the sexual dimorphism of circulating AFABP concentrations. Here we investigated prospectively whether serum AFABP concentrations predict multiple mortality outcomes in men and women alike, using a large clinic-based cohort of individuals with type 2 diabetes, a condition with raised AFABP concentrations. METHODS Baseline serum AFABP concentrations were measured in 5305 research participants with a monoclonal antibody-based sandwich immunoassay. The role of circulating AFABP concentrations in predicting mortality outcomes was evaluated by multivariable Cox regression analysis. RESULTS Among the 5305 participants (59% men) in this study, over a median follow-up of 5 years, there were 512 deaths (19.3 deaths per 1000 person-years). Circulating AFABP concentrations, with higher levels in women at baseline, predicted all-cause mortality (P < 0.001), cardiovascular mortality (P = 0.037), and infection-related deaths (P < 0.002) among all participants. In sex-specific analyses, circulating AFABP concentration was an independent predictor of all-cause mortality in both men and women and a predictor of cancer-related deaths and infection-related deaths in men only. Furthermore, the addition of serum AFABP concentrations improved the time-dependent c statistics in predicting all-cause mortality in participants with type 2 diabetes (P = 0.008). CONCLUSIONS Circulating AFABP concentration was an independent predictor of various mortality outcomes in type 2 diabetes over and above known risk factors of reduced survival in men and women. The role of AFABP as a prognostic biomarker and therapeutic target warrants further investigation.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.clinchem.org-
dc.relation.ispartofClinical Chemistry-
dc.titleCirculating Adipocyte Fatty Acid-Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes-
dc.typeArticle-
dc.identifier.emailLee, CH: pchlee@hku.hk-
dc.identifier.emailCheung, CYY: cyy0219@hku.hk-
dc.identifier.emailWoo, YC: wooyucho@hku.hk-
dc.identifier.emailLui, DTW: dtwlui@hku.hk-
dc.identifier.emailYuen, MMA: mmayuen@hku.hk-
dc.identifier.emailFong, CHY: kalofong@hku.hk-
dc.identifier.emailChow, WS: chowws01@hkucc.hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.authorityLee, CH=rp02043-
dc.identifier.authorityCheung, CYY=rp02243-
dc.identifier.authorityLui, DTW=rp02803-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.authorityLam, KSL=rp00343-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1373/clinchem.2018.289157-
dc.identifier.pmid30021923-
dc.identifier.scopuseid_2-s2.0-85054102953-
dc.identifier.hkuros292495-
dc.identifier.hkuros290910-
dc.identifier.hkuros323144-
dc.identifier.volume64-
dc.identifier.issue10-
dc.identifier.spage1496-
dc.identifier.epage1504-
dc.identifier.eissn1530-8561-
dc.identifier.isiWOS:000448304500013-
dc.publisher.placeUnited States-
dc.identifier.issnl0009-9147-

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