File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.3389/fnagi.2017.00108
- Scopus: eid_2-s2.0-85018369864
- PMID: 28484386
- WOS: WOS:000400193300001
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: The Integrity of the Corpus Callosum Mitigates the Impact of Blood Pressure on the Ventral Attention Network and Information Processing Speed in Healthy Adults
Title | The Integrity of the Corpus Callosum Mitigates the Impact of Blood Pressure on the Ventral Attention Network and Information Processing Speed in Healthy Adults |
---|---|
Authors | |
Keywords | Blood pressure Brain connectivity Cognitive function Aging MRI |
Issue Date | 2017 |
Publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/aging_neuroscience |
Citation | Frontiers in Aging Neuroscience, 2017, v. 9, article no. 108 How to Cite? |
Abstract | Hypertension is a risk factor for cognitive impairment in older age. However, evidence of the neural basis of the relationship between the deterioration of cognitive function and elevated blood pressure is sparse. Based on previous research, we speculate that variations in brain connectivity are closely related to elevated blood pressure even before the onset of clinical conditions and apparent cognitive decline in individuals over 60 years of age. Forty cognitively healthy adults were recruited. Each received a blood pressure test before and after the cognitive assessment in various domains. Diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rsfMRI) data were collected. Our findings confirm that elevated blood pressure is associated with brain connectivity variations in cognitively healthy individuals. The integrity of the splenium of the corpus callosum is closely related to individual differences in systolic blood pressure. In particular, elevated systolic blood pressure is related to resting-state ventral attention network (VAN) and information processing speed. Serial mediation analyses have further revealed that lower integrity of the splenium statistically predicts elevated systolic blood pressure, which in turn predicts weakened functional connectivity (FC) within the VAN and eventually poorer processing speed. The current study sheds light on how neural correlates are involved in the impact of elevated blood pressure on cognitive functioning. |
Persistent Identifier | http://hdl.handle.net/10722/261683 |
ISSN | 2023 Impact Factor: 4.1 2023 SCImago Journal Rankings: 1.173 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wong, NML | - |
dc.contributor.author | Ma, EPW | - |
dc.contributor.author | Lee, TMC | - |
dc.date.accessioned | 2018-09-28T04:45:59Z | - |
dc.date.available | 2018-09-28T04:45:59Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Frontiers in Aging Neuroscience, 2017, v. 9, article no. 108 | - |
dc.identifier.issn | 1663-4365 | - |
dc.identifier.uri | http://hdl.handle.net/10722/261683 | - |
dc.description.abstract | Hypertension is a risk factor for cognitive impairment in older age. However, evidence of the neural basis of the relationship between the deterioration of cognitive function and elevated blood pressure is sparse. Based on previous research, we speculate that variations in brain connectivity are closely related to elevated blood pressure even before the onset of clinical conditions and apparent cognitive decline in individuals over 60 years of age. Forty cognitively healthy adults were recruited. Each received a blood pressure test before and after the cognitive assessment in various domains. Diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rsfMRI) data were collected. Our findings confirm that elevated blood pressure is associated with brain connectivity variations in cognitively healthy individuals. The integrity of the splenium of the corpus callosum is closely related to individual differences in systolic blood pressure. In particular, elevated systolic blood pressure is related to resting-state ventral attention network (VAN) and information processing speed. Serial mediation analyses have further revealed that lower integrity of the splenium statistically predicts elevated systolic blood pressure, which in turn predicts weakened functional connectivity (FC) within the VAN and eventually poorer processing speed. The current study sheds light on how neural correlates are involved in the impact of elevated blood pressure on cognitive functioning. | - |
dc.language | eng | - |
dc.publisher | Frontiers Research Foundation. The Journal's web site is located at http://www.frontiersin.org/aging_neuroscience | - |
dc.relation.ispartof | Frontiers in Aging Neuroscience | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Blood pressure | - |
dc.subject | Brain connectivity | - |
dc.subject | Cognitive function | - |
dc.subject | Aging | - |
dc.subject | MRI | - |
dc.title | The Integrity of the Corpus Callosum Mitigates the Impact of Blood Pressure on the Ventral Attention Network and Information Processing Speed in Healthy Adults | - |
dc.type | Article | - |
dc.identifier.email | Wong, NML: nichol.wong@hku.hk | - |
dc.identifier.email | Lee, TMC: tmclee@hku.hk | - |
dc.identifier.authority | Wong, NML=rp02749 | - |
dc.identifier.authority | Lee, TMC=rp00564 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3389/fnagi.2017.00108 | - |
dc.identifier.pmid | 28484386 | - |
dc.identifier.pmcid | PMC5402183 | - |
dc.identifier.scopus | eid_2-s2.0-85018369864 | - |
dc.identifier.hkuros | 292633 | - |
dc.identifier.volume | 9 | - |
dc.identifier.spage | article no. 108 | - |
dc.identifier.epage | article no. 108 | - |
dc.identifier.isi | WOS:000400193300001 | - |
dc.publisher.place | Switzerland | - |
dc.identifier.issnl | 1663-4365 | - |