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Article: Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine
Title | Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine |
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Authors | |
Issue Date | 2017 |
Publisher | European Centre for Disease Prevention and Control. The Journal's web site is located at http://www.eurosurveillance.org/Public/AboutUs/AboutUs.aspx |
Citation | Eurosurveillance, 2017, v. 22 n. 50, article no. 16-00824 How to Cite? |
Abstract | Introduction: Hand, foot and mouth disease (HFMD) is usually caused by several serotypes from human enterovirus A species, including enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16). Two inactivated monovalent EV-A71 vaccines have been recently licensed in China and monovalent CV-A16 vaccine and bivalent EV-A71 and CV-A16 vaccine are under development. Methods: Using notifications from the national surveillance system, we describe the epidemiology and dynamics of HFMD in the country, before the introduction of EV-A71 vaccination, from 2008 through 2015. Results: Laboratory-identified serotype categories, i.e. CV-A16, EV-A71 and other enteroviruses, circulated annually. EV-A71 remained the most virulent serotype and was the major serotype for fatal cases (range: 88.5–95.4%) and severe cases (range: 50.7– 82.3%) across years. Except for 2013 and 2015, when other enteroviruses were more frequently found in mild HFMD (48.8% and 52.5%), EV-A71 was more frequently detected from mild cases in the rest of the years covered by the study (range: 39.4–52.6%). The incidence rates and severity risks of HFMD associated with all serotype categories were the highest for children aged 1 year and younger, and decreased with increasing age. Discussion/conclusion: This study provides baseline epidemiology for evaluation of vaccine impact and potential serotype replacement. |
Persistent Identifier | http://hdl.handle.net/10722/261635 |
ISSN | 2023 Impact Factor: 9.9 2023 SCImago Journal Rankings: 2.881 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yang, B | - |
dc.contributor.author | Liu, F | - |
dc.contributor.author | Liao, Q | - |
dc.contributor.author | Wu, P | - |
dc.contributor.author | Chang, Z | - |
dc.contributor.author | Huang, J | - |
dc.contributor.author | Long, L | - |
dc.contributor.author | Luo, L | - |
dc.contributor.author | Li, Y | - |
dc.contributor.author | Leung, GM | - |
dc.contributor.author | Cowling, BJ | - |
dc.contributor.author | Yu, H | - |
dc.date.accessioned | 2018-09-28T04:45:04Z | - |
dc.date.available | 2018-09-28T04:45:04Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Eurosurveillance, 2017, v. 22 n. 50, article no. 16-00824 | - |
dc.identifier.issn | 1025-496X | - |
dc.identifier.uri | http://hdl.handle.net/10722/261635 | - |
dc.description.abstract | Introduction: Hand, foot and mouth disease (HFMD) is usually caused by several serotypes from human enterovirus A species, including enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16). Two inactivated monovalent EV-A71 vaccines have been recently licensed in China and monovalent CV-A16 vaccine and bivalent EV-A71 and CV-A16 vaccine are under development. Methods: Using notifications from the national surveillance system, we describe the epidemiology and dynamics of HFMD in the country, before the introduction of EV-A71 vaccination, from 2008 through 2015. Results: Laboratory-identified serotype categories, i.e. CV-A16, EV-A71 and other enteroviruses, circulated annually. EV-A71 remained the most virulent serotype and was the major serotype for fatal cases (range: 88.5–95.4%) and severe cases (range: 50.7– 82.3%) across years. Except for 2013 and 2015, when other enteroviruses were more frequently found in mild HFMD (48.8% and 52.5%), EV-A71 was more frequently detected from mild cases in the rest of the years covered by the study (range: 39.4–52.6%). The incidence rates and severity risks of HFMD associated with all serotype categories were the highest for children aged 1 year and younger, and decreased with increasing age. Discussion/conclusion: This study provides baseline epidemiology for evaluation of vaccine impact and potential serotype replacement. | - |
dc.language | eng | - |
dc.publisher | European Centre for Disease Prevention and Control. The Journal's web site is located at http://www.eurosurveillance.org/Public/AboutUs/AboutUs.aspx | - |
dc.relation.ispartof | Eurosurveillance | - |
dc.rights | Eurosurveillance. Copyright © European Centre for Disease Prevention and Control. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Epidemiology of hand, foot and mouth disease in China, 2008 to 2015 prior to the introduction of EV-A71 vaccine | - |
dc.type | Article | - |
dc.identifier.email | Wu, P: pengwu@hku.hk | - |
dc.identifier.email | Leung, GM: gmleung@hku.hk | - |
dc.identifier.email | Cowling, BJ: bcowling@hku.hk | - |
dc.identifier.authority | Wu, P=rp02025 | - |
dc.identifier.authority | Leung, GM=rp00460 | - |
dc.identifier.authority | Cowling, BJ=rp01326 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.2807/1560-7917.ES.2017.22.50.16-00824 | - |
dc.identifier.pmid | 29258646 | - |
dc.identifier.pmcid | PMC5743100 | - |
dc.identifier.scopus | eid_2-s2.0-85039035088 | - |
dc.identifier.hkuros | 292651 | - |
dc.identifier.volume | 22 | - |
dc.identifier.issue | 50 | - |
dc.identifier.spage | article no. 16-00824 | - |
dc.identifier.epage | article no. 16-00824 | - |
dc.identifier.isi | WOS:000418086600006 | - |
dc.publisher.place | Sweden | - |
dc.identifier.issnl | 1025-496X | - |