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Conference Paper: Serotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors
Title | Serotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors |
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Authors | |
Issue Date | 2017 |
Publisher | Society for Neuroscience. The Journal's web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings |
Citation | Society for Neuroscience 2017 Annual Meeting, Washington DC, USA, 11–15 November 2017. In Neuroscience 2017 Abstracts, p. no. 286.23 How to Cite? |
Abstract | The medial vestibular nucleus (MVN) is a major relay station for postural coordination, eye movement control and spatial cognition. Microinjection of 5-HT to the MVN impaired performance of vestibular-mediated motor balance and negative geotaxis in both adult and juvenile (P13-16) rats. We hypothesize that serotonergic neurotransmission modulates the activity of neurons in the MVN circuitry for vestibular-related behaviors. Specific activation of 5-HT7 receptors in the MVN restricted circuit plasticity by abolishing NMDAR-mediated LTD via a protein kinase A (PKA)-dependent postsynaptic mechanism. Activation of 5-HT1A receptor attenuated the excitability of vestibular circuits, as evidenced by reduction of both evoked excitatory and inhibitory transmission (eEPSC and eIPSC), through a presynaptic mechanism. These results reveal that 5-HT1A and 5-HT7 receptors within the MVN exhibit differential modulatory mechanisms but these in concert accomplish synergistic influence on motor coordination. |
Description | Poster Presentation - Session 286 - Monamines - Topic: B.01. Neurotransmitters and Signaling Molecules - no. 286.23 / C53 |
Persistent Identifier | http://hdl.handle.net/10722/261423 |
DC Field | Value | Language |
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dc.contributor.author | Chan, YS | - |
dc.contributor.author | Han, L | - |
dc.contributor.author | Li, YH | - |
dc.contributor.author | Wu, LK | - |
dc.contributor.author | Shum, DKY | - |
dc.date.accessioned | 2018-09-14T08:57:53Z | - |
dc.date.available | 2018-09-14T08:57:53Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Society for Neuroscience 2017 Annual Meeting, Washington DC, USA, 11–15 November 2017. In Neuroscience 2017 Abstracts, p. no. 286.23 | - |
dc.identifier.uri | http://hdl.handle.net/10722/261423 | - |
dc.description | Poster Presentation - Session 286 - Monamines - Topic: B.01. Neurotransmitters and Signaling Molecules - no. 286.23 / C53 | - |
dc.description.abstract | The medial vestibular nucleus (MVN) is a major relay station for postural coordination, eye movement control and spatial cognition. Microinjection of 5-HT to the MVN impaired performance of vestibular-mediated motor balance and negative geotaxis in both adult and juvenile (P13-16) rats. We hypothesize that serotonergic neurotransmission modulates the activity of neurons in the MVN circuitry for vestibular-related behaviors. Specific activation of 5-HT7 receptors in the MVN restricted circuit plasticity by abolishing NMDAR-mediated LTD via a protein kinase A (PKA)-dependent postsynaptic mechanism. Activation of 5-HT1A receptor attenuated the excitability of vestibular circuits, as evidenced by reduction of both evoked excitatory and inhibitory transmission (eEPSC and eIPSC), through a presynaptic mechanism. These results reveal that 5-HT1A and 5-HT7 receptors within the MVN exhibit differential modulatory mechanisms but these in concert accomplish synergistic influence on motor coordination. | - |
dc.language | eng | - |
dc.publisher | Society for Neuroscience. The Journal's web site is located at https://www.sfn.org/annual-meeting/past-and-future-annual-meetings | - |
dc.relation.ispartof | Society for Neuroscience Abstracts | - |
dc.rights | Society for Neuroscience Abstracts. Copyright © Society for Neuroscience. | - |
dc.title | Serotonin restricts synaptic plasticity and decreases excitability of vestibular circuits via distinct receptors | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Chan, YS: yschan@hku.hk | - |
dc.identifier.email | Han, L: rahanlei@hku.hk | - |
dc.identifier.email | Wu, LK: lwu03@hku.hk | - |
dc.identifier.email | Shum, DKY: shumdkhk@hkucc.hku.hk | - |
dc.identifier.authority | Chan, YS=rp00318 | - |
dc.identifier.authority | Shum, DKY=rp00321 | - |
dc.identifier.hkuros | 291266 | - |
dc.identifier.spage | no. 286.23 | - |
dc.identifier.epage | no. 286.23 | - |
dc.publisher.place | United States | - |