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Article: Combined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection

TitleCombined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection
Authors
Yan, LLi, OTWPoh, CMPerera, RAPMDoak, SAPeiris, JSMPoon, LML
KeywordsHeterosubtypic immunity
Influenza
Universal vaccine
Issue Date2018
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 2018, v. 525, p. 73-82 How to Cite?
DOI: http://dx.doi.org/10.1016/j.virol.2018.09.007
AbstractThe limited protection of current commerical vaccines necessitates the investigation of novel vaccine strategies for unpredictable outbreaks. To investigate the feasibility of using vaccines derived from Group 1 influenza A virus to induce broadly cross-reactive immune responses against multiple influenza subtypes, we tested a panel of sequential 4-dose immunization regimens in mice. Mice were treated with inactivated (seasonal H1N1, pandemic H1N1 and H5N1) and vaccinia virus-based H5N1 live-attenuated vaccines in different combinations. Mice were then challenged by viruses of either Group 1 (H1N1) or Group 2 (H3N2, H7N7) influenza virus. All studied sequential 4-dose vaccinations could induce some degrees of heterosubtypic protection in mice. Amongst all these regimens, the combined use of inactivated and live-attenuated vaccines could achieve the best heterologous protection. These results highlight the synergistic effect of combining different vaccine platforms to enhance heterosubtypic protection against influenza viruses.
Persistent Identifierhttp://hdl.handle.net/10722/261234
ISSN
0042-6822
2021 Impact Factor: 3.513
2020 SCImago Journal Rankings: 1.389
ISI Accession Number ID
WOS:000452938600008

 

DC FieldValueLanguage
dc.contributor.authorYan, L-
dc.contributor.authorLi, OTW-
dc.contributor.authorPoh, CM-
dc.contributor.authorPerera, RAPM-
dc.contributor.authorDoak, SA-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorPoon, LML-
dc.date.accessioned2018-09-14T08:54:46Z-
dc.date.available2018-09-14T08:54:46Z-
dc.date.issued2018-
dc.identifier.citationVirology, 2018, v. 525, p. 73-82-
dc.identifier.issn0042-6822-
dc.identifier.urihttp://hdl.handle.net/10722/261234-
dc.description.abstractThe limited protection of current commerical vaccines necessitates the investigation of novel vaccine strategies for unpredictable outbreaks. To investigate the feasibility of using vaccines derived from Group 1 influenza A virus to induce broadly cross-reactive immune responses against multiple influenza subtypes, we tested a panel of sequential 4-dose immunization regimens in mice. Mice were treated with inactivated (seasonal H1N1, pandemic H1N1 and H5N1) and vaccinia virus-based H5N1 live-attenuated vaccines in different combinations. Mice were then challenged by viruses of either Group 1 (H1N1) or Group 2 (H3N2, H7N7) influenza virus. All studied sequential 4-dose vaccinations could induce some degrees of heterosubtypic protection in mice. Amongst all these regimens, the combined use of inactivated and live-attenuated vaccines could achieve the best heterologous protection. These results highlight the synergistic effect of combining different vaccine platforms to enhance heterosubtypic protection against influenza viruses.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro-
dc.relation.ispartofVirology-
dc.subjectHeterosubtypic immunity-
dc.subjectInfluenza-
dc.subjectUniversal vaccine-
dc.titleCombined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection-
dc.typeArticle-
dc.identifier.emailYan, L: ylmeng@hku.hk-
dc.identifier.emailPoh, CM: pohcm@hku.hk-
dc.identifier.emailPerera, RAPM: mahenp@hku.hk-
dc.identifier.emailDoak, SA: sophiev@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.emailPoon, LML: llmpoon@hkucc.hku.hk-
dc.identifier.authorityDoak, SA=rp02141-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.identifier.authorityPoon, LML=rp00484-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.virol.2018.09.007-
dc.identifier.pmid30248524-
dc.identifier.scopuseid_2-s2.0-85053722283-
dc.identifier.hkuros291639-
dc.identifier.hkuros293645-
dc.identifier.volume525-
dc.identifier.spage73-
dc.identifier.epage82-
dc.identifier.isiWOS:000452938600008-
dc.publisher.placeUnited States-
dc.identifier.issnl0042-6822-

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