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- Publisher Website: 10.1016/j.biomaterials.2018.05.011
- Scopus: eid_2-s2.0-85046732970
- PMID: 29763774
- WOS: WOS:000436223500001
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Article: Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration
Title | Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration |
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Authors | |
Keywords | Core-shell microspheres Microfluidic capillary device Precisely controlled magnesium ion release Biocompatibility Bone regeneration |
Issue Date | 2018 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials |
Citation | Biomaterials, 2018, v. 174, p. 1-16 How to Cite? |
Abstract | A range of magnesium ions (Mg2+) used has demonstrated osteogenic tendency in vitro. Hence, we propose to actualize this concept by designing a new system to precisely control the Mg2+ delivery at a particular concentration in vivo in order to effectively stimulate in-situ bone regeneration. To achieve this objective, a monodisperse core-shell microsphere delivery system comprising of poly (lactic-co-glycolic acid) (PLGA) biopolymer, alginate hydrogel, and magnesium oxide nano-particles has been designed by using customized microfluidic capillary device. The PLGA-MgO sponge-like spherical core works as a reservoir of Mg2+ while the alginate shell serves as physical barrier to control the outflow of Mg2+ at ∼50 ppm accurately for 2 weeks via its adjustable surface micro-porous network. With the aid of controlled release of Mg2+, the new core-shell microsphere system can effectively enhance osteoblastic activity in vitro and stimulate in-situ bone regeneration in vivo in terms of total bone volume, bone mineral density (BMD), and trabecular thickness after operation. Interestingly, the Young's moduli of formed bone on the core-shell microsphere group have been restored to ∼96% of that of the surrounding matured bone. These findings indicate that the concept of precisely controlled release of Mg2+ may potentially apply for in-situ bone regeneration clinically. |
Persistent Identifier | http://hdl.handle.net/10722/261134 |
ISSN | 2023 Impact Factor: 12.8 2023 SCImago Journal Rankings: 3.016 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lin, Z | - |
dc.contributor.author | Wu, J | - |
dc.contributor.author | Qiao, W | - |
dc.contributor.author | Zhao, Y | - |
dc.contributor.author | Wong, KHM | - |
dc.contributor.author | Chu, PK | - |
dc.contributor.author | Bian, L | - |
dc.contributor.author | Wu, S | - |
dc.contributor.author | Zheng, Y | - |
dc.contributor.author | Cheung, KMC | - |
dc.contributor.author | Leung, F | - |
dc.contributor.author | Yeung, KWK | - |
dc.date.accessioned | 2018-09-14T08:53:03Z | - |
dc.date.available | 2018-09-14T08:53:03Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Biomaterials, 2018, v. 174, p. 1-16 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10722/261134 | - |
dc.description.abstract | A range of magnesium ions (Mg2+) used has demonstrated osteogenic tendency in vitro. Hence, we propose to actualize this concept by designing a new system to precisely control the Mg2+ delivery at a particular concentration in vivo in order to effectively stimulate in-situ bone regeneration. To achieve this objective, a monodisperse core-shell microsphere delivery system comprising of poly (lactic-co-glycolic acid) (PLGA) biopolymer, alginate hydrogel, and magnesium oxide nano-particles has been designed by using customized microfluidic capillary device. The PLGA-MgO sponge-like spherical core works as a reservoir of Mg2+ while the alginate shell serves as physical barrier to control the outflow of Mg2+ at ∼50 ppm accurately for 2 weeks via its adjustable surface micro-porous network. With the aid of controlled release of Mg2+, the new core-shell microsphere system can effectively enhance osteoblastic activity in vitro and stimulate in-situ bone regeneration in vivo in terms of total bone volume, bone mineral density (BMD), and trabecular thickness after operation. Interestingly, the Young's moduli of formed bone on the core-shell microsphere group have been restored to ∼96% of that of the surrounding matured bone. These findings indicate that the concept of precisely controlled release of Mg2+ may potentially apply for in-situ bone regeneration clinically. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials | - |
dc.relation.ispartof | Biomaterials | - |
dc.subject | Core-shell microspheres | - |
dc.subject | Microfluidic capillary device | - |
dc.subject | Precisely controlled magnesium ion release | - |
dc.subject | Biocompatibility | - |
dc.subject | Bone regeneration | - |
dc.title | Precisely controlled delivery of magnesium ions thru sponge-like monodisperse PLGA/nano-MgO-alginate core-shell microsphere device to enable in-situ bone regeneration | - |
dc.type | Article | - |
dc.identifier.email | Qiao, W: drqiao@hku.hk | - |
dc.identifier.email | Wong, KHM: khmwong@hku.hk | - |
dc.identifier.email | Cheung, KMC: cheungmc@hku.hk | - |
dc.identifier.email | Leung, F: klleunga@hkucc.hku.hk | - |
dc.identifier.email | Yeung, KWK: wkkyeung@hku.hk | - |
dc.identifier.authority | Qiao, W=rp02919 | - |
dc.identifier.authority | Cheung, KMC=rp00387 | - |
dc.identifier.authority | Leung, F=rp00297 | - |
dc.identifier.authority | Yeung, KWK=rp00309 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.biomaterials.2018.05.011 | - |
dc.identifier.pmid | 29763774 | - |
dc.identifier.scopus | eid_2-s2.0-85046732970 | - |
dc.identifier.hkuros | 290251 | - |
dc.identifier.volume | 174 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 16 | - |
dc.identifier.isi | WOS:000436223500001 | - |
dc.publisher.place | Netherlands | - |