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Conference Paper: Relationship between B cell signatures and disease flare in lupus nephritis patients

TitleRelationship between B cell signatures and disease flare in lupus nephritis patients
Authors
Issue Date2017
PublisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org
Citation
American Society of Nephrology Kidney Week, New Orleans, USA, 31 October - 5 November 2017, In Journal of the American Society of Nephrology, 2017, v. 28 n. Abstract Suppl., p. 583 How to Cite?
AbstractBackground: Nephritic flares in patients with lupus nephritis (LN) reduce renal survival but factors contributing to flares remain elusive. Perturbations of B cell subsets have been implicated in the pathogenesis of LN, but the relationship between B cell signatures and relapse has not been investigated. Methods: We compared circulating B cell subsets and signatures (miRNA148a, BACH1, BACH2 and PAX5) in the serum and plasma cells during disease quiescence between Class III/IV±V LN patients who are multiple relapsers (MR, defined as ≥3 relapses within 36 months unrelated to non-compliance) or non-relapsers (NR, defined as no relapse after the presenting episode). Results: 33 patients were included (MR n=20; NR n=13). MR showed lower percentage of circulating naïve and memory B cells (0.48%, IQR 0.24%-3.15% vs. 4.52%, IQR 3.18%-8.25%; and 0.51%, IQR 0.26%-0.67% vs. 0.96%, IQR 0.86%-1.91%; p=0.014 and 0.014 respectively) and higher plasma cell-to-naïve B cell ratio (1.52±2.19 vs. 0.21±0.33, p=0.011) compared with NR. MR had higher miRNA148a in serum and plasma cells compared with NR [relative expression (RQ) 4.25±2.86 vs. 0.71±0.55 and 3.53±1.56 vs. 1.38±1.17, p=0.002 and 0.128] (Figure 1A). MR also showed lower BACH2 expression in circulating plasma cells [RQ 12.86±3.10 vs. 28.10±11.87, p=0.036)], but no difference in BACH1 and PAX5 (p>0.05 for both) (Figure 1B). Conclusions: Elevated serum and plasma cell miRNA148a might be related to BACH2 downregulation in plasma cells and altered circulating B cell subsets, thereby increasing risk of LN relapse.
DescriptionPoster presentation: Glomerular: Basic/Experimental Immunology and Inflammation - II - no. FR-PO697
Persistent Identifierhttp://hdl.handle.net/10722/260766
ISSN
2020 Impact Factor: 10.121
2020 SCImago Journal Rankings: 4.451

 

DC FieldValueLanguage
dc.contributor.authorYap, YHD-
dc.contributor.authorTang, CSO-
dc.contributor.authorYung, S-
dc.contributor.authorYam, I-
dc.contributor.authorLee, P-
dc.contributor.authorTam, C-
dc.contributor.authorChan, DTM-
dc.date.accessioned2018-09-14T08:47:02Z-
dc.date.available2018-09-14T08:47:02Z-
dc.date.issued2017-
dc.identifier.citationAmerican Society of Nephrology Kidney Week, New Orleans, USA, 31 October - 5 November 2017, In Journal of the American Society of Nephrology, 2017, v. 28 n. Abstract Suppl., p. 583-
dc.identifier.issn1046-6673-
dc.identifier.urihttp://hdl.handle.net/10722/260766-
dc.descriptionPoster presentation: Glomerular: Basic/Experimental Immunology and Inflammation - II - no. FR-PO697-
dc.description.abstractBackground: Nephritic flares in patients with lupus nephritis (LN) reduce renal survival but factors contributing to flares remain elusive. Perturbations of B cell subsets have been implicated in the pathogenesis of LN, but the relationship between B cell signatures and relapse has not been investigated. Methods: We compared circulating B cell subsets and signatures (miRNA148a, BACH1, BACH2 and PAX5) in the serum and plasma cells during disease quiescence between Class III/IV±V LN patients who are multiple relapsers (MR, defined as ≥3 relapses within 36 months unrelated to non-compliance) or non-relapsers (NR, defined as no relapse after the presenting episode). Results: 33 patients were included (MR n=20; NR n=13). MR showed lower percentage of circulating naïve and memory B cells (0.48%, IQR 0.24%-3.15% vs. 4.52%, IQR 3.18%-8.25%; and 0.51%, IQR 0.26%-0.67% vs. 0.96%, IQR 0.86%-1.91%; p=0.014 and 0.014 respectively) and higher plasma cell-to-naïve B cell ratio (1.52±2.19 vs. 0.21±0.33, p=0.011) compared with NR. MR had higher miRNA148a in serum and plasma cells compared with NR [relative expression (RQ) 4.25±2.86 vs. 0.71±0.55 and 3.53±1.56 vs. 1.38±1.17, p=0.002 and 0.128] (Figure 1A). MR also showed lower BACH2 expression in circulating plasma cells [RQ 12.86±3.10 vs. 28.10±11.87, p=0.036)], but no difference in BACH1 and PAX5 (p>0.05 for both) (Figure 1B). Conclusions: Elevated serum and plasma cell miRNA148a might be related to BACH2 downregulation in plasma cells and altered circulating B cell subsets, thereby increasing risk of LN relapse.-
dc.languageeng-
dc.publisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org-
dc.relation.ispartofJournal of the American Society of Nephrology-
dc.relation.ispartofAmerican Society of Nephrology Kidney Week, 2017-
dc.titleRelationship between B cell signatures and disease flare in lupus nephritis patients-
dc.typeConference_Paper-
dc.identifier.emailYap, YHD: desmondy@hku.hk-
dc.identifier.emailYam, I: iylyam@hkucc.hku.hk-
dc.identifier.emailChan, DTM: dtmchan@hkucc.hku.hk-
dc.identifier.authorityYap, YHD=rp01607-
dc.identifier.authorityChan, DTM=rp00394-
dc.identifier.hkuros290812-
dc.identifier.volume28-
dc.identifier.issueAbstract Suppl.-
dc.identifier.spage583-
dc.identifier.epage583-
dc.publisher.placeUnited States-
dc.identifier.issnl1046-6673-

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