File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Optogenetic auditory fMRI reveals the effects of visual cortical inputs on auditory midbrain response

TitleOptogenetic auditory fMRI reveals the effects of visual cortical inputs on auditory midbrain response
Authors
Issue Date2018
PublisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2018, v. 8, p. 8736 How to Cite?
AbstractSensory cortices contain extensive descending (corticofugal) pathways, yet their impact on brainstem processing - particularly across sensory systems - remains poorly understood. In the auditory system, the inferior colliculus (IC) in the midbrain receives cross-modal inputs from the visual cortex (VC). However, the influences from VC on auditory midbrain processing are unclear. To investigate whether and how visual cortical inputs affect IC auditory responses, the present study combines auditory blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) with cell-type specific optogenetic manipulation of visual cortex. The results show that predominant optogenetic excitation of the excitatory pyramidal neurons in the infragranular layers of the primary VC enhances the noise-evoked BOLD fMRI responses within the IC. This finding reveals that inputs from VC influence and facilitate basic sound processing in the auditory midbrain. Such combined optogenetic and auditory fMRI approach can shed light on the large-scale modulatory effects of corticofugal pathways and guide detailed electrophysiological studies in the future.
Persistent Identifierhttp://hdl.handle.net/10722/260445
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.900
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeong, TL-
dc.contributor.authorDong, M-
dc.contributor.authorGao, P-
dc.contributor.authorChan, RW-
dc.contributor.authorTo, KWA-
dc.contributor.authorSanes, DH-
dc.contributor.authorWu, EX-
dc.date.accessioned2018-09-14T08:41:50Z-
dc.date.available2018-09-14T08:41:50Z-
dc.date.issued2018-
dc.identifier.citationScientific Reports, 2018, v. 8, p. 8736-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/260445-
dc.description.abstractSensory cortices contain extensive descending (corticofugal) pathways, yet their impact on brainstem processing - particularly across sensory systems - remains poorly understood. In the auditory system, the inferior colliculus (IC) in the midbrain receives cross-modal inputs from the visual cortex (VC). However, the influences from VC on auditory midbrain processing are unclear. To investigate whether and how visual cortical inputs affect IC auditory responses, the present study combines auditory blood-oxygenation-level-dependent (BOLD) functional MRI (fMRI) with cell-type specific optogenetic manipulation of visual cortex. The results show that predominant optogenetic excitation of the excitatory pyramidal neurons in the infragranular layers of the primary VC enhances the noise-evoked BOLD fMRI responses within the IC. This finding reveals that inputs from VC influence and facilitate basic sound processing in the auditory midbrain. Such combined optogenetic and auditory fMRI approach can shed light on the large-scale modulatory effects of corticofugal pathways and guide detailed electrophysiological studies in the future.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals - Option C. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleOptogenetic auditory fMRI reveals the effects of visual cortical inputs on auditory midbrain response-
dc.typeArticle-
dc.identifier.emailLeong, TL: tlleong@hku.hk-
dc.identifier.emailTo, KWA: toanthea@hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-018-26568-1-
dc.identifier.scopuseid_2-s2.0-85048237116-
dc.identifier.hkuros291491-
dc.identifier.volume8-
dc.identifier.spage8736-
dc.identifier.epage8736-
dc.identifier.isiWOS:000434376700038-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl2045-2322-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats