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- Publisher Website: 10.1021/acs.nanolett.6b03588
- Scopus: eid_2-s2.0-85011977350
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Article: Ultrasensitive Phototriggered Local Anesthesia
Title | Ultrasensitive Phototriggered Local Anesthesia |
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Authors | |
Keywords | gold nanorod liposome local anesthesia Phototriggering tetrodotoxin |
Issue Date | 2017 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/nanolett |
Citation | Nano Letters, 2017, v. 17 n. 2, p. 660-665 How to Cite? |
Abstract | An injectable local anesthetic producing repeatable on-demand nerve block would be desirable for pain management. Here we present a phototriggerable device to achieve repeatable and adjustable on-demand local anesthesia in superficial or deep tissues, consisting of gold nanorods attached to low temperature sensitive liposomes (LTSL). The particles were loaded with tetrodotoxin and dexmedetomidine. Near-infrared light (NIR, 808 nm, continuous wave) could heat gold nanorods at low fluence (short duration and low irradiance), leading to rapid release of payload. In vivo, 1–2 min of irradiation at ≤272 mW/cm2 produced repeatable and adjustable on-demand infiltration anesthesia or sciatic nerve blockade with minimal toxicity. The nerve block intensity and duration correlated with the irradiance and duration of the applied light. |
Persistent Identifier | http://hdl.handle.net/10722/260282 |
ISSN | 2023 Impact Factor: 9.6 2023 SCImago Journal Rankings: 3.411 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Zhan, CY | - |
dc.contributor.author | Wang, W | - |
dc.contributor.author | Santamaria, C | - |
dc.contributor.author | Wang, B | - |
dc.contributor.author | Rwei, A | - |
dc.contributor.author | Timko, BP | - |
dc.contributor.author | Kohane, DS | - |
dc.date.accessioned | 2018-09-12T07:37:12Z | - |
dc.date.available | 2018-09-12T07:37:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Nano Letters, 2017, v. 17 n. 2, p. 660-665 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | http://hdl.handle.net/10722/260282 | - |
dc.description.abstract | An injectable local anesthetic producing repeatable on-demand nerve block would be desirable for pain management. Here we present a phototriggerable device to achieve repeatable and adjustable on-demand local anesthesia in superficial or deep tissues, consisting of gold nanorods attached to low temperature sensitive liposomes (LTSL). The particles were loaded with tetrodotoxin and dexmedetomidine. Near-infrared light (NIR, 808 nm, continuous wave) could heat gold nanorods at low fluence (short duration and low irradiance), leading to rapid release of payload. In vivo, 1–2 min of irradiation at ≤272 mW/cm2 produced repeatable and adjustable on-demand infiltration anesthesia or sciatic nerve blockade with minimal toxicity. The nerve block intensity and duration correlated with the irradiance and duration of the applied light. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/nanolett | - |
dc.relation.ispartof | Nano Letters | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.subject | gold nanorod | - |
dc.subject | liposome | - |
dc.subject | local anesthesia | - |
dc.subject | Phototriggering | - |
dc.subject | tetrodotoxin | - |
dc.title | Ultrasensitive Phototriggered Local Anesthesia | - |
dc.type | Article | - |
dc.identifier.email | Wang, W: wangwp@hku.hk | - |
dc.identifier.authority | Wang, W=rp02227 | - |
dc.identifier.doi | 10.1021/acs.nanolett.6b03588 | - |
dc.identifier.scopus | eid_2-s2.0-85011977350 | - |
dc.identifier.volume | 17 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 660 | - |
dc.identifier.epage | 665 | - |
dc.identifier.isi | WOS:000393848800009 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1530-6984 | - |