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Article: Phototriggered targeting of nanocarriers for drug delivery
Title | Phototriggered targeting of nanocarriers for drug delivery |
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Authors | |
Keywords | photocleavable groups photorelease photoresponsive nanoparticles phototargeting stimuli-responsive drug delivery targeted drug delivery |
Issue Date | 2018 |
Publisher | Tsinghua University Press, co-published with Springer Verlag. The Journal's web site is located at http://www.springer.com/materials/nanotechnology/journal/12274 |
Citation | Nano Research, 2018, v. 11 n. 10, p. 5424-5438 How to Cite? |
Abstract | Stimuli-triggered targeting of drug delivery systems can both increase the therapeutic efficacy and lower toxicity by selectively delivering drugs at target sites with high specificity and efficiency. Light is a convenient and powerful stimulus for use in such drug delivery systems because it is readily available and noninvasive and offers excellent spatiotemporal control. The power and wavelength of light can be finely tuned for different photoresponsive systems to achieve efficient targeting at the tissue, cellular, or subcellular levels. Here, we have reviewed the various mechanisms for phototriggered targeting (phototargeting) of drug nanocarriers. We have discussed the three main phototargeting strategies: (1) targeting ligand activation; (2) particle size reduction; and (3) blood vessel disruption. |
Persistent Identifier | http://hdl.handle.net/10722/259126 |
ISSN | 2023 Impact Factor: 9.5 2023 SCImago Journal Rankings: 2.539 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, Y | - |
dc.contributor.author | Zhang, Y | - |
dc.contributor.author | Wang, W | - |
dc.date.accessioned | 2018-09-03T04:01:53Z | - |
dc.date.available | 2018-09-03T04:01:53Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Nano Research, 2018, v. 11 n. 10, p. 5424-5438 | - |
dc.identifier.issn | 1998-0124 | - |
dc.identifier.uri | http://hdl.handle.net/10722/259126 | - |
dc.description.abstract | Stimuli-triggered targeting of drug delivery systems can both increase the therapeutic efficacy and lower toxicity by selectively delivering drugs at target sites with high specificity and efficiency. Light is a convenient and powerful stimulus for use in such drug delivery systems because it is readily available and noninvasive and offers excellent spatiotemporal control. The power and wavelength of light can be finely tuned for different photoresponsive systems to achieve efficient targeting at the tissue, cellular, or subcellular levels. Here, we have reviewed the various mechanisms for phototriggered targeting (phototargeting) of drug nanocarriers. We have discussed the three main phototargeting strategies: (1) targeting ligand activation; (2) particle size reduction; and (3) blood vessel disruption. | - |
dc.language | eng | - |
dc.publisher | Tsinghua University Press, co-published with Springer Verlag. The Journal's web site is located at http://www.springer.com/materials/nanotechnology/journal/12274 | - |
dc.relation.ispartof | Nano Research | - |
dc.subject | photocleavable groups | - |
dc.subject | photorelease | - |
dc.subject | photoresponsive nanoparticles | - |
dc.subject | phototargeting | - |
dc.subject | stimuli-responsive drug delivery | - |
dc.subject | targeted drug delivery | - |
dc.title | Phototriggered targeting of nanocarriers for drug delivery | - |
dc.type | Article | - |
dc.identifier.email | Wang, W: wangwp@hku.hk | - |
dc.identifier.authority | Wang, W=rp02227 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1007/s12274-018-2132-7 | - |
dc.identifier.scopus | eid_2-s2.0-85049795460 | - |
dc.identifier.hkuros | 287769 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 5424 | - |
dc.identifier.epage | 5438 | - |
dc.identifier.isi | WOS:000446423900024 | - |
dc.publisher.place | China | - |
dc.description.version | full-text view-only version | - |
dc.identifier.issnl | 1998-0000 | - |