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Conference Paper: Two Cases of IgG4-Related Sclerosing Disease Presenting at the Tarsal Conjunctiva
Title | Two Cases of IgG4-Related Sclerosing Disease Presenting at the Tarsal Conjunctiva |
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Authors | |
Issue Date | 2018 |
Citation | The 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress in conjunction with the 29th Hong Kong Ophthalmological Symposium, Hong Kong, 8-11 February 2018. In Abstract Book, p.301 How to Cite? |
Abstract | Purpose: IgG4-related disease is a relatively
recent disease entity, increasingly recognized for
its involvement of the orbital tissues and lacrimal
glands. We report a series of 2 patients with unusual
presentations of IgG4-related sclerosing disease of the
eyelid.
Methods: We report of 2 unusual cases of eyelid
conjunctival mass where biopsy result was found to be
IgG4-related sclerosing disease.
Results: A 66-year-old man with a 9-month history
of right eye discomfort was incidentally found to
have large and firm conjunctival nodules over the
right upper eyelid tarsal plate; the largest size was
13 x 8 mm. An incisional biopsy showed IgG4-related
sclerosing disease with IgG4 plasma cells over 100 HPF
and IgG4:IgG ratio over 80%. The patient had normal
serum IgG level. Topical antibiotic and steroid ointment
was given afterward. Residual nodules resolved
spontaneously. The second case was a 51-year-old
female with a 2-month history of right eye epiphora.
An excisional biopsy showed increased proportion of
IgG4+ plasma cells. The IgG4/IgG plasma cell ratio was
70%. Presence of lacrimal glands was also noted in the
specimen. Serum IgG level was normal and IgG4 was
high at 1.228 g/L (N = 0.168-1.000 g/L). In both cases
computed tomography (CT) of the orbit showed no
orbital mass and there was no systemic involvement.
Both patients did not receive any systemic steroid
treatment. There was no recurrence after 3 years and
7 months in the first case and 15 months in the second
case.
Conclusions: IgG4-related disease can have a wide
range of ocular manifestations including eyelid
conjunctival involvement. |
Description | e-poster |
Persistent Identifier | http://hdl.handle.net/10722/258476 |
DC Field | Value | Language |
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dc.contributor.author | Cheung, JJC | - |
dc.contributor.author | Chong, SSY | - |
dc.date.accessioned | 2018-08-22T01:39:03Z | - |
dc.date.available | 2018-08-22T01:39:03Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | The 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress in conjunction with the 29th Hong Kong Ophthalmological Symposium, Hong Kong, 8-11 February 2018. In Abstract Book, p.301 | - |
dc.identifier.uri | http://hdl.handle.net/10722/258476 | - |
dc.description | e-poster | - |
dc.description.abstract | Purpose: IgG4-related disease is a relatively recent disease entity, increasingly recognized for its involvement of the orbital tissues and lacrimal glands. We report a series of 2 patients with unusual presentations of IgG4-related sclerosing disease of the eyelid. Methods: We report of 2 unusual cases of eyelid conjunctival mass where biopsy result was found to be IgG4-related sclerosing disease. Results: A 66-year-old man with a 9-month history of right eye discomfort was incidentally found to have large and firm conjunctival nodules over the right upper eyelid tarsal plate; the largest size was 13 x 8 mm. An incisional biopsy showed IgG4-related sclerosing disease with IgG4 plasma cells over 100 HPF and IgG4:IgG ratio over 80%. The patient had normal serum IgG level. Topical antibiotic and steroid ointment was given afterward. Residual nodules resolved spontaneously. The second case was a 51-year-old female with a 2-month history of right eye epiphora. An excisional biopsy showed increased proportion of IgG4+ plasma cells. The IgG4/IgG plasma cell ratio was 70%. Presence of lacrimal glands was also noted in the specimen. Serum IgG level was normal and IgG4 was high at 1.228 g/L (N = 0.168-1.000 g/L). In both cases computed tomography (CT) of the orbit showed no orbital mass and there was no systemic involvement. Both patients did not receive any systemic steroid treatment. There was no recurrence after 3 years and 7 months in the first case and 15 months in the second case. Conclusions: IgG4-related disease can have a wide range of ocular manifestations including eyelid conjunctival involvement. | - |
dc.language | eng | - |
dc.relation.ispartof | The 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress in conjunction with the 29th Hong Kong Ophthalmological Symposium | - |
dc.title | Two Cases of IgG4-Related Sclerosing Disease Presenting at the Tarsal Conjunctiva | - |
dc.type | Conference_Paper | - |
dc.identifier.email | Cheung, JJC: janicejc@hku.hk | - |
dc.identifier.authority | Cheung, JJC=rp02219 | - |
dc.identifier.hkuros | 287704 | - |
dc.publisher.place | Hong Kong | - |