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Article: Child-Pugh Parameters and Platelet Count as an Alternative to ICG Test for Assessing Liver Function for Major Hepatectomy
Title | Child-Pugh Parameters and Platelet Count as an Alternative to ICG Test for Assessing Liver Function for Major Hepatectomy |
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Authors | |
Issue Date | 2017 |
Citation | HPB Surgery, 2017, v. 2017, article no. 2948030 How to Cite? |
Abstract | Objective. To study the correlations and discrepancies between Child-Pugh system and indocyanine green (ICG) clearance test in assessing liver function reserve and explore the possibility of combining two systems to gain an overall liver function assessment. Design. Retrospective analysis of 2832 hepatocellular carcinoma (HCC) patients graded as Child-Pugh A and Child-Pugh B with ICG clearance test being performed was conducted. Results. ICG retention rate at 15 minutes (ICG15) correlates with Child-Pugh score, however, with a large variance. Platelet count improves the correlation between Child-Pugh score and ICG15. ICG15 can be estimated using the following regression formula: estimated ICG15 (eICG15) = 45.1 + 0.435 × bilirubin - 0.917 × albumin + 0.491 × prothrombin time - 0.0283 × platelet (R2=0.455). Patients with eICG15 > 20.0% who underwent major hepatectomy had a tendency towards more posthepatectomy liver failure (4.1% versus 8.0%, p=0.09) and higher in-hospital mortality (3.7% versus 8.0%, p=0.052). They also had shorter median overall survival (5.10±0.553 versus 3.01±0.878 years, p=0.015) and disease-free survival (1.37±0.215 versus 0.707±0.183 years, p=0.018). Conclusion. eICG15 can be predicted from Child-Pugh parameters and platelet count. eICG15 correlates with in-hospital mortality after major hepatectomy and predicts long-term survival. |
Persistent Identifier | http://hdl.handle.net/10722/254464 |
ISSN | 2020 SCImago Journal Rankings: 0.561 |
DC Field | Value | Language |
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dc.contributor.author | Au, KP | - |
dc.contributor.author | Chan, SC | - |
dc.contributor.author | Chok, KSH | - |
dc.contributor.author | Chan, ACY | - |
dc.contributor.author | Cheung, TT | - |
dc.contributor.author | Ng, KKC | - |
dc.contributor.author | Lo, CM | - |
dc.date.accessioned | 2018-06-19T15:40:37Z | - |
dc.date.available | 2018-06-19T15:40:37Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | HPB Surgery, 2017, v. 2017, article no. 2948030 | - |
dc.identifier.issn | 0894-8569 | - |
dc.identifier.uri | http://hdl.handle.net/10722/254464 | - |
dc.description.abstract | Objective. To study the correlations and discrepancies between Child-Pugh system and indocyanine green (ICG) clearance test in assessing liver function reserve and explore the possibility of combining two systems to gain an overall liver function assessment. Design. Retrospective analysis of 2832 hepatocellular carcinoma (HCC) patients graded as Child-Pugh A and Child-Pugh B with ICG clearance test being performed was conducted. Results. ICG retention rate at 15 minutes (ICG15) correlates with Child-Pugh score, however, with a large variance. Platelet count improves the correlation between Child-Pugh score and ICG15. ICG15 can be estimated using the following regression formula: estimated ICG15 (eICG15) = 45.1 + 0.435 × bilirubin - 0.917 × albumin + 0.491 × prothrombin time - 0.0283 × platelet (R2=0.455). Patients with eICG15 > 20.0% who underwent major hepatectomy had a tendency towards more posthepatectomy liver failure (4.1% versus 8.0%, p=0.09) and higher in-hospital mortality (3.7% versus 8.0%, p=0.052). They also had shorter median overall survival (5.10±0.553 versus 3.01±0.878 years, p=0.015) and disease-free survival (1.37±0.215 versus 0.707±0.183 years, p=0.018). Conclusion. eICG15 can be predicted from Child-Pugh parameters and platelet count. eICG15 correlates with in-hospital mortality after major hepatectomy and predicts long-term survival. | - |
dc.language | eng | - |
dc.relation.ispartof | HPB Surgery | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Child-Pugh Parameters and Platelet Count as an Alternative to ICG Test for Assessing Liver Function for Major Hepatectomy | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1155/2017/2948030 | - |
dc.identifier.scopus | eid_2-s2.0-85029815360 | - |
dc.identifier.hkuros | 288606 | - |
dc.identifier.volume | 2017 | - |
dc.identifier.spage | article no. 2948030 | - |
dc.identifier.epage | article no. 2948030 | - |
dc.identifier.eissn | 1607-8462 | - |
dc.identifier.issnl | 0894-8569 | - |