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Article: Diversity among POU transcription factors in chromatin recognition and cell fate reprogramming

TitleDiversity among POU transcription factors in chromatin recognition and cell fate reprogramming
Authors
KeywordsTranscriptional regulation
Cellular reprogramming
Pioneer TFs
POU
Issue Date2018
Citation
Cellular and Molecular Life Sciences, 2018, v. 75, n. 9, p. 1587-1612 How to Cite?
Abstract© 2018, Springer International Publishing AG, part of Springer Nature. The POU (Pit-Oct-Unc) protein family is an evolutionary ancient group of transcription factors (TFs) that bind specific DNA sequences to direct gene expression programs. The fundamental importance of POU TFs to orchestrate embryonic development and to direct cellular fate decisions is well established, but the molecular basis for this activity is insufficiently understood. POU TFs possess a bipartite ‘two-in-one’ DNA binding domain consisting of two independently folding structural units connected by a poorly conserved and flexible linker. Therefore, they represent a paradigmatic example to study the molecular basis for the functional versatility of TFs. Their modular architecture endows POU TFs with the capacity to accommodate alternative composite DNA sequences by adopting different quaternary structures. Moreover, associations with partner proteins crucially influence the selection of their DNA binding sites. The plentitude of DNA binding modes confers the ability to POU TFs to regulate distinct genes in the context of different cellular environments. Likewise, different binding modes of POU proteins to DNA could trigger alternative regulatory responses in the context of different genomic locations of the same cell. Prominent POU TFs such as Oct4, Brn2, Oct6 and Brn4 are not only essential regulators of development but have also been successfully employed to reprogram somatic cells to pluripotency and neural lineages. Here we review biochemical, structural, genomic and cellular reprogramming studies to examine how the ability of POU TFs to select regulatory DNA, alone or with p artner factors, is tied to their capacity to epigenetically remodel chromatin and drive specific regulatory programs that give cells their identities.
Persistent Identifierhttp://hdl.handle.net/10722/253185
ISSN
2020 Impact Factor: 9.261
2020 SCImago Journal Rankings: 2.928
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMalik, Vikas-
dc.contributor.authorZimmer, Dennis-
dc.contributor.authorJauch, Ralf-
dc.date.accessioned2018-05-11T05:38:50Z-
dc.date.available2018-05-11T05:38:50Z-
dc.date.issued2018-
dc.identifier.citationCellular and Molecular Life Sciences, 2018, v. 75, n. 9, p. 1587-1612-
dc.identifier.issn1420-682X-
dc.identifier.urihttp://hdl.handle.net/10722/253185-
dc.description.abstract© 2018, Springer International Publishing AG, part of Springer Nature. The POU (Pit-Oct-Unc) protein family is an evolutionary ancient group of transcription factors (TFs) that bind specific DNA sequences to direct gene expression programs. The fundamental importance of POU TFs to orchestrate embryonic development and to direct cellular fate decisions is well established, but the molecular basis for this activity is insufficiently understood. POU TFs possess a bipartite ‘two-in-one’ DNA binding domain consisting of two independently folding structural units connected by a poorly conserved and flexible linker. Therefore, they represent a paradigmatic example to study the molecular basis for the functional versatility of TFs. Their modular architecture endows POU TFs with the capacity to accommodate alternative composite DNA sequences by adopting different quaternary structures. Moreover, associations with partner proteins crucially influence the selection of their DNA binding sites. The plentitude of DNA binding modes confers the ability to POU TFs to regulate distinct genes in the context of different cellular environments. Likewise, different binding modes of POU proteins to DNA could trigger alternative regulatory responses in the context of different genomic locations of the same cell. Prominent POU TFs such as Oct4, Brn2, Oct6 and Brn4 are not only essential regulators of development but have also been successfully employed to reprogram somatic cells to pluripotency and neural lineages. Here we review biochemical, structural, genomic and cellular reprogramming studies to examine how the ability of POU TFs to select regulatory DNA, alone or with p artner factors, is tied to their capacity to epigenetically remodel chromatin and drive specific regulatory programs that give cells their identities.-
dc.languageeng-
dc.relation.ispartofCellular and Molecular Life Sciences-
dc.subjectTranscriptional regulation-
dc.subjectCellular reprogramming-
dc.subjectPioneer TFs-
dc.subjectPOU-
dc.titleDiversity among POU transcription factors in chromatin recognition and cell fate reprogramming-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00018-018-2748-5-
dc.identifier.scopuseid_2-s2.0-85041346358-
dc.identifier.volume75-
dc.identifier.issue9-
dc.identifier.spage1587-
dc.identifier.epage1612-
dc.identifier.eissn1420-9071-
dc.identifier.isiWOS:000429922000007-
dc.identifier.issnl1420-682X-

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