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Article: Molecular basis for the genome engagement by Sox proteins

TitleMolecular basis for the genome engagement by Sox proteins
Authors
KeywordsSox
Transcription factors
Gene regulation
DNA binding
Cellular reprogramming
Issue Date2017
Citation
Seminars in Cell and Developmental Biology, 2017, v. 63, p. 2-12 How to Cite?
Abstract© 2016 The Author(s) The Sox transcription factor family consists of 20 members in the human genome. Many of them are key determinants of cellular identities and possess the capacity to reprogram cell fates by pioneering the epigenetic remodeling of the genome. This activity is intimately tied to their ability to specifically bind and bend DNA alone or with other proteins. Here we discuss our current knowledge on how Sox transcription factors such as Sox2, Sox17, Sox18 and Sox9 ‘read’ the genome to find and regulate their target genes and highlight the roles of partner factors including Pax6, Nanog, Oct4 and Brn2. We integrate insights from structural and biochemical studies as well as high-throughput assays to probe DNA specificity in vitro as well as in cells and tissues.
Persistent Identifierhttp://hdl.handle.net/10722/253123
ISSN
2020 Impact Factor: 7.727
2020 SCImago Journal Rankings: 3.071
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHou, Linlin-
dc.contributor.authorSrivastava, Yogesh-
dc.contributor.authorJauch, Ralf-
dc.date.accessioned2018-05-11T05:38:40Z-
dc.date.available2018-05-11T05:38:40Z-
dc.date.issued2017-
dc.identifier.citationSeminars in Cell and Developmental Biology, 2017, v. 63, p. 2-12-
dc.identifier.issn1084-9521-
dc.identifier.urihttp://hdl.handle.net/10722/253123-
dc.description.abstract© 2016 The Author(s) The Sox transcription factor family consists of 20 members in the human genome. Many of them are key determinants of cellular identities and possess the capacity to reprogram cell fates by pioneering the epigenetic remodeling of the genome. This activity is intimately tied to their ability to specifically bind and bend DNA alone or with other proteins. Here we discuss our current knowledge on how Sox transcription factors such as Sox2, Sox17, Sox18 and Sox9 ‘read’ the genome to find and regulate their target genes and highlight the roles of partner factors including Pax6, Nanog, Oct4 and Brn2. We integrate insights from structural and biochemical studies as well as high-throughput assays to probe DNA specificity in vitro as well as in cells and tissues.-
dc.languageeng-
dc.relation.ispartofSeminars in Cell and Developmental Biology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectSox-
dc.subjectTranscription factors-
dc.subjectGene regulation-
dc.subjectDNA binding-
dc.subjectCellular reprogramming-
dc.titleMolecular basis for the genome engagement by Sox proteins-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.semcdb.2016.08.005-
dc.identifier.pmid27521520-
dc.identifier.scopuseid_2-s2.0-84995467769-
dc.identifier.volume63-
dc.identifier.spage2-
dc.identifier.epage12-
dc.identifier.eissn1096-3634-
dc.identifier.isiWOS:000395504500002-
dc.identifier.issnl1084-9521-

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