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- Publisher Website: 10.1016/j.str.2003.09.015
- Scopus: eid_2-s2.0-0242626894
- PMID: 14604529
- WOS: WOS:000186472500014
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Article: The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module
Title | The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module |
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Authors | |
Issue Date | 2003 |
Citation | Structure, 2003, v. 11, n. 11, p. 1393-1402 How to Cite? |
Abstract | About one-third of the more than 300 C2H2 zinc finger proteins of Drosophila contain a conserved sequence motif, the zinc finger-associated domain (ZAD). Genes that encode ZAD proteins are specific for and expanded in the genomes of insects. Only three ZAD-encoding gene functions are established, and the role of ZAD is unknown. Here we present the crystal structure of the ZAD of Grauzone (ZAD Grau ), a Drosophila transcription factor that specifically controls the maternal Cdc20-like APC subunit Cortex. ZAD forms an atypical treble-clef-like zinc-coordinating fold. Head-to-tail arrangement of two ZAD Grau molecules in the crystals suggests dimer formation, an observation supported by crosslinking and dynamic light scattering. The results indicate that ZAD provides a novel protein-protein interaction module that characterizes a large family of insect transcription factors. |
Persistent Identifier | http://hdl.handle.net/10722/253095 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 2.456 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Jauch, Ralf | - |
dc.contributor.author | Bourenkov, Gleb P. | - |
dc.contributor.author | Chung, Ho Ryun | - |
dc.contributor.author | Urlaub, Henning | - |
dc.contributor.author | Reidt, Ulrich | - |
dc.contributor.author | Jäckle, Herbert | - |
dc.contributor.author | Wahl, Markus C. | - |
dc.date.accessioned | 2018-05-11T05:38:35Z | - |
dc.date.available | 2018-05-11T05:38:35Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Structure, 2003, v. 11, n. 11, p. 1393-1402 | - |
dc.identifier.issn | 0969-2126 | - |
dc.identifier.uri | http://hdl.handle.net/10722/253095 | - |
dc.description.abstract | About one-third of the more than 300 C2H2 zinc finger proteins of Drosophila contain a conserved sequence motif, the zinc finger-associated domain (ZAD). Genes that encode ZAD proteins are specific for and expanded in the genomes of insects. Only three ZAD-encoding gene functions are established, and the role of ZAD is unknown. Here we present the crystal structure of the ZAD of Grauzone (ZAD Grau ), a Drosophila transcription factor that specifically controls the maternal Cdc20-like APC subunit Cortex. ZAD forms an atypical treble-clef-like zinc-coordinating fold. Head-to-tail arrangement of two ZAD Grau molecules in the crystals suggests dimer formation, an observation supported by crosslinking and dynamic light scattering. The results indicate that ZAD provides a novel protein-protein interaction module that characterizes a large family of insect transcription factors. | - |
dc.language | eng | - |
dc.relation.ispartof | Structure | - |
dc.title | The zinc finger-associated domain of the Drosophila transcription factor grauzone is a novel zinc-coordinating protein-protein interaction module | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1016/j.str.2003.09.015 | - |
dc.identifier.pmid | 14604529 | - |
dc.identifier.scopus | eid_2-s2.0-0242626894 | - |
dc.identifier.volume | 11 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 1393 | - |
dc.identifier.epage | 1402 | - |
dc.identifier.isi | WOS:000186472500014 | - |
dc.identifier.issnl | 0969-2126 | - |