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Article: Biological activities of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) derived from EPA and DHA: New anti-arrhythmic compounds?

TitleBiological activities of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) derived from EPA and DHA: New anti-arrhythmic compounds?
Authors
KeywordsArrhythmias
Isoprostanes
Neuroprostanes
Non-enzymatic metabolites
Oxidative stress
Issue Date2018
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/mam
Citation
Molecular Aspects of Medicine, 2018, v. 64, p. 161-168 How to Cite?
AbstractOmega 3 Polyunsaturated fatty acids (omega 3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely omega 3 PUFAs per se that are biologically active but the nonenzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes and neuroprostanes. Recent question arises how these molecules take part in physiological homeostasis, show biological bioactivities and anti-inflammatory properties. Furthermore, they are involved in the circulations of childbirth, by inducing the closure of the ductus arteriosus. In addition, oxidative stress which can be beneficial for the heart in given environmental conditions such as the presence of omega 3 PUFAs on the site of the stress and the signaling pathways involved are also explained in this review.
Persistent Identifierhttp://hdl.handle.net/10722/252139
ISSN
2019 Impact Factor: 9.577
2015 SCImago Journal Rankings: 6.371
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorGalano, JM-
dc.contributor.authorRoy, J-
dc.contributor.authorDurand, T-
dc.contributor.authorLee, CYJ-
dc.contributor.authorLe Guennec, JY-
dc.contributor.authorOger, C-
dc.contributor.authorDemion, M-
dc.date.accessioned2018-04-11T03:54:28Z-
dc.date.available2018-04-11T03:54:28Z-
dc.date.issued2018-
dc.identifier.citationMolecular Aspects of Medicine, 2018, v. 64, p. 161-168-
dc.identifier.issn0098-2997-
dc.identifier.urihttp://hdl.handle.net/10722/252139-
dc.description.abstractOmega 3 Polyunsaturated fatty acids (omega 3 PUFAs) have several biological properties including anti-arrhythmic effects. However, there are some evidences that it is not solely omega 3 PUFAs per se that are biologically active but the nonenzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) like isoprostanes and neuroprostanes. Recent question arises how these molecules take part in physiological homeostasis, show biological bioactivities and anti-inflammatory properties. Furthermore, they are involved in the circulations of childbirth, by inducing the closure of the ductus arteriosus. In addition, oxidative stress which can be beneficial for the heart in given environmental conditions such as the presence of omega 3 PUFAs on the site of the stress and the signaling pathways involved are also explained in this review.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/mam-
dc.relation.ispartofMolecular Aspects of Medicine-
dc.subjectArrhythmias-
dc.subjectIsoprostanes-
dc.subjectNeuroprostanes-
dc.subjectNon-enzymatic metabolites-
dc.subjectOxidative stress-
dc.titleBiological activities of non-enzymatic oxygenated metabolites of polyunsaturated fatty acids (NEO-PUFAs) derived from EPA and DHA: New anti-arrhythmic compounds?-
dc.typeArticle-
dc.identifier.emailLee, CYJ: jettylee@hku.hk-
dc.identifier.authorityLee, CYJ=rp01511-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.mam.2018.03.003-
dc.identifier.pmid29572110-
dc.identifier.scopuseid_2-s2.0-85044372960-
dc.identifier.hkuros284776-
dc.identifier.volume64-
dc.identifier.spage161-
dc.identifier.epage168-
dc.identifier.isiWOS:000448206400011-
dc.publisher.placeUnited Kingdom-

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