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postgraduate thesis: Neuropsychological functioning of people with Moyamoya disease
Title | Neuropsychological functioning of people with Moyamoya disease |
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Authors | |
Issue Date | 2016 |
Publisher | The University of Hong Kong (Pokfulam, Hong Kong) |
Citation | Tse, Y. [謝殷正]. (2016). Neuropsychological functioning of people with Moyamoya disease. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. |
Abstract | Moyamoya Disease (MMD) is a chronic, idiopathic, progressive cerebrovascular condition causing the abnormal narrowing or obstruction of cranial arteries around the Circle of Willis, causing a mesh of compensatory collateral capillaries to develop across the sites manifesting as “a hazy puff of smoke” (known as “Moyamoya” in Japanese). Patients are at risk of suffering from cardiovascular accidents that often prompt them to undergo surgery. Individuals with Moyamoya Disease often suffer from neuropsychological impairments in executive functions, complex attention and memory, currently understood to be related to prolonged disruption of blood flow due to the abnormal arterial growth. It remained unclear by far whether such impairments are reversible through surgical revascularization. The current study investigated patterns of neuropsychological changes upon surgical revascularization, attempting to take into account practice effects with a matched healthy comparison group. Associated with the rarity of disease and thus inevitably small sample size (n=11) of MMD patients, no conclusion based on inferential statistics could be obtained in this study. However, descriptive data pointed towards the direction that memory functions showed more reversibility than other cognitive domains which was consistent with current neuroscientific understanding of exclusively substantial adult neurogenesis of hippocampus. Executive functions and complex attention appeared to receive no benefit from surgery.
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Degree | Master of Social Sciences |
Subject | Moyamoya disease - Patients Neuropsychology |
Dept/Program | Clinical Psychology |
Persistent Identifier | http://hdl.handle.net/10722/251969 |
DC Field | Value | Language |
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dc.contributor.author | Tse, Yan-ching | - |
dc.contributor.author | 謝殷正 | - |
dc.date.accessioned | 2018-04-09T14:36:39Z | - |
dc.date.available | 2018-04-09T14:36:39Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Tse, Y. [謝殷正]. (2016). Neuropsychological functioning of people with Moyamoya disease. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR. | - |
dc.identifier.uri | http://hdl.handle.net/10722/251969 | - |
dc.description.abstract | Moyamoya Disease (MMD) is a chronic, idiopathic, progressive cerebrovascular condition causing the abnormal narrowing or obstruction of cranial arteries around the Circle of Willis, causing a mesh of compensatory collateral capillaries to develop across the sites manifesting as “a hazy puff of smoke” (known as “Moyamoya” in Japanese). Patients are at risk of suffering from cardiovascular accidents that often prompt them to undergo surgery. Individuals with Moyamoya Disease often suffer from neuropsychological impairments in executive functions, complex attention and memory, currently understood to be related to prolonged disruption of blood flow due to the abnormal arterial growth. It remained unclear by far whether such impairments are reversible through surgical revascularization. The current study investigated patterns of neuropsychological changes upon surgical revascularization, attempting to take into account practice effects with a matched healthy comparison group. Associated with the rarity of disease and thus inevitably small sample size (n=11) of MMD patients, no conclusion based on inferential statistics could be obtained in this study. However, descriptive data pointed towards the direction that memory functions showed more reversibility than other cognitive domains which was consistent with current neuroscientific understanding of exclusively substantial adult neurogenesis of hippocampus. Executive functions and complex attention appeared to receive no benefit from surgery. | - |
dc.language | eng | - |
dc.publisher | The University of Hong Kong (Pokfulam, Hong Kong) | - |
dc.relation.ispartof | HKU Theses Online (HKUTO) | - |
dc.rights | The author retains all proprietary rights, (such as patent rights) and the right to use in future works. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject.lcsh | Moyamoya disease - Patients | - |
dc.subject.lcsh | Neuropsychology | - |
dc.title | Neuropsychological functioning of people with Moyamoya disease | - |
dc.type | PG_Thesis | - |
dc.description.thesisname | Master of Social Sciences | - |
dc.description.thesislevel | Master | - |
dc.description.thesisdiscipline | Clinical Psychology | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.5353/th_991043983789103414 | - |
dc.date.hkucongregation | 2016 | - |
dc.identifier.mmsid | 991043983789103414 | - |