File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/ece3.285
- Scopus: eid_2-s2.0-84864577968
- WOS: WOS:000312448400027
Supplementary
- Citations:
- Appears in Collections:
Article: Evolution of MHC class I genes in the European badger (Meles meles)
Title | Evolution of MHC class I genes in the European badger (Meles meles) |
---|---|
Authors | |
Keywords | Balancing selection Trans-species polymorphism Orthology Major histocompatibility complex Concerted evolution Birth-and-death evolution |
Issue Date | 2012 |
Citation | Ecology and Evolution, 2012, v. 2, n. 7, p. 1644-1662 How to Cite? |
Abstract | The major histocompatibility complex (MHC) plays a central role in the adaptive immune system and provides a good model with which to understand the evolutionary processes underlying functional genes. Trans-species polymorphism and orthology are both commonly found in MHC genes; however, mammalian MHC class I genes tend to cluster by species. Concerted evolution has the potential to homogenize different loci, whereas birth-and-death evolution can lead to the loss of orthologs; both processes result in monophyletic groups within species. Studies investigating the evolution of MHC class I genes have been biased toward a few particular taxa and model species. We present the first study of MHC class I genes in a species from the superfamily Musteloidea. The European badger (Meles meles) exhibits moderate variation in MHC class I sequences when compared to other carnivores. We identified seven putatively functional sequences and nine pseudogenes from genomic (gDNA) and complementary (cDNA) DNA, signifying at least two functional class I loci. We found evidence for separate evolutionary histories of the α1 and α2/α3 domains. In the α1 domain, several sequences from different species were more closely related to each other than to sequences from the same species, resembling orthology or trans-species polymorphism. Balancing selection and probable recombination maintain genetic diversity in the α1 domain, evidenced by the detection of positive selection and a recombination event. By comparison, two recombination breakpoints indicate that the α2/α3 domains have most likely undergone concerted evolution,where recombination has homogenized the α2/α3 domains between genes, leading to species-specific clusters of sequences. Our findings highlight the importance of analyzing MHC domains separately. © 2012 The Authors. |
Persistent Identifier | http://hdl.handle.net/10722/251617 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sin, Yung Wa | - |
dc.contributor.author | Dugdale, Hannah L. | - |
dc.contributor.author | Newman, Chris | - |
dc.contributor.author | Macdonald, David W. | - |
dc.contributor.author | Burke, Terry | - |
dc.date.accessioned | 2018-03-08T05:00:29Z | - |
dc.date.available | 2018-03-08T05:00:29Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Ecology and Evolution, 2012, v. 2, n. 7, p. 1644-1662 | - |
dc.identifier.uri | http://hdl.handle.net/10722/251617 | - |
dc.description.abstract | The major histocompatibility complex (MHC) plays a central role in the adaptive immune system and provides a good model with which to understand the evolutionary processes underlying functional genes. Trans-species polymorphism and orthology are both commonly found in MHC genes; however, mammalian MHC class I genes tend to cluster by species. Concerted evolution has the potential to homogenize different loci, whereas birth-and-death evolution can lead to the loss of orthologs; both processes result in monophyletic groups within species. Studies investigating the evolution of MHC class I genes have been biased toward a few particular taxa and model species. We present the first study of MHC class I genes in a species from the superfamily Musteloidea. The European badger (Meles meles) exhibits moderate variation in MHC class I sequences when compared to other carnivores. We identified seven putatively functional sequences and nine pseudogenes from genomic (gDNA) and complementary (cDNA) DNA, signifying at least two functional class I loci. We found evidence for separate evolutionary histories of the α1 and α2/α3 domains. In the α1 domain, several sequences from different species were more closely related to each other than to sequences from the same species, resembling orthology or trans-species polymorphism. Balancing selection and probable recombination maintain genetic diversity in the α1 domain, evidenced by the detection of positive selection and a recombination event. By comparison, two recombination breakpoints indicate that the α2/α3 domains have most likely undergone concerted evolution,where recombination has homogenized the α2/α3 domains between genes, leading to species-specific clusters of sequences. Our findings highlight the importance of analyzing MHC domains separately. © 2012 The Authors. | - |
dc.language | eng | - |
dc.relation.ispartof | Ecology and Evolution | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Balancing selection | - |
dc.subject | Trans-species polymorphism | - |
dc.subject | Orthology | - |
dc.subject | Major histocompatibility complex | - |
dc.subject | Concerted evolution | - |
dc.subject | Birth-and-death evolution | - |
dc.title | Evolution of MHC class I genes in the European badger (Meles meles) | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1002/ece3.285 | - |
dc.identifier.scopus | eid_2-s2.0-84864577968 | - |
dc.identifier.volume | 2 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1644 | - |
dc.identifier.epage | 1662 | - |
dc.identifier.eissn | 2045-7758 | - |
dc.identifier.isi | WOS:000312448400027 | - |
dc.identifier.issnl | 2045-7758 | - |